The effect of stretching on transmural shear wave anisotropy in cardiac shear wave elastography: An ex vivo and in silico study

Caenen, Annette; Thabit, Abdullah; Pernot, Mathieu; Shcherbakova, Darya; Mertens, Luc; Swillens, Abigaïl; Segers, Patrick

doi:10.1109/ultsym.2017.8091930

Cited by 3 publications

(1 citation statement)

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“…Even though our simulations provided the advantage of access to the full control of the true tissue mechanical properties, there are some limitations inherently linked to the simulation framework. First, the myocardium was modelled as a linear viscoelastic isotropic media, whereas it is generally known that material nonlinearity and anisotropy can also affect wave propagation (Bezy et al 2021;Caenen et al 2017b;Couade et al 2011;E.M.Lifshitz 1970). Second, even though the theoretical validation of the plate model in Fig.…”

Section: Discussionmentioning

confidence: 99%

Comparing Myocardial Shear Wave Propagation Velocity Estimation Methods Based on Tissue Displacement, Velocity and Acceleration Data

Селиверстова¹,

Caenen²,

Bezy³

et al. 2022

Ultrasound in Medicine & Biology

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Section: Discussionmentioning

confidence: 99%

Comparing Myocardial Shear Wave Propagation Velocity Estimation Methods Based on Tissue Displacement, Velocity and Acceleration Data

Селиверстова¹,

Caenen²,

Bezy³

et al. 2022

Ultrasound in Medicine & Biology

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A direct comparison of natural and acoustic-radiation-force-induced cardiac mechanical waves

Keijzer

Caenen

Voorneveld

et al. 2020

Sci Rep

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Natural and active shear wave elastography (SWE) are potential ultrasound-based techniques to non-invasively assess myocardial stiffness, which could improve current diagnosis of heart failure. This study aims to bridge the knowledge gap between both techniques and discuss their respective impacts on cardiac stiffness evaluation. We recorded the mechanical waves occurring after aortic and mitral valve closure (AVC, MVC) and those induced by acoustic radiation force throughout the cardiac cycle in four pigs after sternotomy. Natural SWE showed a higher feasibility than active SWE, which is an advantage for clinical application. Median propagation speeds of 2.5–4.0 m/s and 1.6–4.0 m/s were obtained after AVC and MVC, whereas ARF-based median speeds of 0.9–1.2 m/s and 2.1–3.8 m/s were reported for diastole and systole, respectively. The different wave characteristics in both methods, such as the frequency content, complicate the direct comparison of waves. Nevertheless, a good match was found in propagation speeds between natural and active SWE at the moment of valve closure, and the natural waves showed higher propagation speeds than in diastole. Furthermore, the results demonstrated that the natural waves occur in between diastole and systole identified with active SWE, and thus represent a myocardial stiffness in between relaxation and contraction.

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Transmural Wave Speed Gradient May Distinguish Intrinsic Myocardial Stiffening From Preload-Induced Changes in Operational Stiffness in Shear Wave Elastography

Caenen

Bezy²,

Petrescu³

et al. 2023

IEEE Trans. Biomed. Eng.

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Background: Shear wave elastography (SWE) 7 is a promising technique to non-invasively assess myocar-8 dial stiffness based on the propagation speed of mechan-9 ical waves. However, a high wave propagation speed can 10 either be attributed to an elevated intrinsic myocardial stiff-11 ness or to a preload-induced increase in operational stiff-12 ness. Objective: Our objective was to find a way to discrim-13 inate intrinsic myocardial stiffening from stiffening caused 14 by an increased pressure in SWE. Methods: We used the 15 finite element method to study the shear wave propagation 16 patterns when stiffness and/or pressure is elevated, com-17 pared to normal stiffness and pressure. Numerical findings 18 were verified in a few human subjects. Results: The trans-19 mural wave speed gradient was able to distinguish changes 20 in intrinsic stiffness from those induced by differing hemo-21 dynamic load (a speed of ±3.2 m/s in parasternal short-axis 22 (PSAX) view was associated with a wave speed gradient of 23 −0.17 ± 0.15 m/s/mm when pressure was elevated com-24 pared to 0.04 ± 0.05 m/s/mm when stiffness was elevated). 25 The gradient however decreased when stiffness increased 26 (decrease with a factor 3 in PSAX when stiffness doubled 27 at 20 mmHg). The human data analysis confirmed the pres-28 ence of a wave speed gradient in a patient with elevated 29 ventricular pressure. Conclusion: Cardiac SWE modeling 30 is a useful tool to gain additional insights into the com-31 plex wave physics and to guide post-processing. The trans-32 mural differences in wave speed may help to distinguish 33 Manuscript

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The effect of stretching on transmural shear wave anisotropy in cardiac shear wave elastography: An ex vivo and in silico study

Cited by 3 publications

References 0 publications

Comparing Myocardial Shear Wave Propagation Velocity Estimation Methods Based on Tissue Displacement, Velocity and Acceleration Data

Comparing Myocardial Shear Wave Propagation Velocity Estimation Methods Based on Tissue Displacement, Velocity and Acceleration Data

A direct comparison of natural and acoustic-radiation-force-induced cardiac mechanical waves

Transmural Wave Speed Gradient May Distinguish Intrinsic Myocardial Stiffening From Preload-Induced Changes in Operational Stiffness in Shear Wave Elastography

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