The effect of sulphur on the antibacterial properties of succinic acid-Cu(II) and mercaptosuccinic acid-Cu(II) MOFs

Gizer, S. Gorkem; Şahiner, Nurettin

doi:10.1016/j.ica.2021.120611

Cited by 8 publications

(2 citation statements)

References 21 publications

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“…Moreover, both the polymers displayed interesting antibacterial properties. 104 Otherwise, biomolecules can be employed as ligands for coordination polymers, especially for metal-organic frameworks, which are known as BioMOFs. Biomolecules possess environmental compatibility, great variety in the functional groups, chirality, and other structural properties, which made them extremely versatile as metal linkers.…”

Section: Green Synthesis Of Mofsmentioning

confidence: 99%

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Scattolin,

Tonon,

Botter

et al. 2024

J. Mater. Chem. B

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Section: Green Synthesis Of Mofsmentioning

confidence: 99%

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Scattolin,

Tonon,

Botter

et al. 2024

J. Mater. Chem. B

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“…In relation to this overview, this work aims mainly to explore and understand the synergistic activity of phosphine ligands and copper, ruthenium or iridium ions, complexes with those metal ions are already known for their intrinsic antibacterial [19][20][21][22][23][24][25], antiviral [26][27][28][29], antifungal [30,31], and anti-inflammatory [32,33] characteristics (Scheme 1). Thanks to a wide range of coordination numbers, redox states, and possible geometries, inorganic compounds seem to possess a remarkable reactivity.…”

Section: Introductionmentioning

confidence: 99%

Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes

et al. 2022

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Two novel phosphine ligands, Ph2PCH2N(CH2CH3)3 (1) and Ph2PCH2N(CH2CH2CH2CH3)2 (2), and six new metal (Cu(I), Ir(III) and Ru(II)) complexes with those ligands: iridium(III) complexes: Ir(η5-Cp*)Cl2(1) (1a), Ir(η5-Cp*)Cl2(2) (2a) (Cp*: Pentamethylcyclopentadienyl); ruthenium(II) complexes: Ru(η6-p-cymene)Cl2(1) (1b), Ru(η6-p-cymene)Cl2(2) (2b) and copper(I) complexes: [Cu(CH3CN)2(1)BF4] (1c), [Cu(CH3CN)2(2)BF4] (2c) were synthesized and characterized using elemental analysis, NMR spectroscopy, and ESI-MS spectrometry. Copper(I) complexes turned out to be highly unstable in the presence of atmospheric oxygen in contrast to ruthenium(II) and iridium(III) complexes. The studied Ru(II) and Ir(III) complexes exhibited promising cytotoxicity towards cancer cells in vitro with IC50 values significantly lower than that of the reference drug—cisplatin. Confocal microscopy analysis showed that Ru(II) and Ir(III) complexes effectively accumulate inside A549 cells with localization in cytoplasm and nuclei. A precise cytometric analysis provided clear evidence for the predominance of apoptosis in induced cell death. Furthermore, the complexes presumably induce the changes in the cell cycle leading to G2/M phase arrest in a dose-dependent manner. Gel electrophoresis experiments revealed that Ru(II) and Ir(III) inorganic compounds showed their unusual low genotoxicity towards plasmid DNA. Additionally, metal complexes were able to generate reactive oxygen species as a result of redox processes, proved by gel electrophoresis and cyclic voltamperometry. In vitro cytotoxicity assays were also carried out within multicellular tumor spheroids and efficient anticancer action on these 3D assemblies was demonstrated. It was proven that the hydrocarbon chain elongation of the phosphine ligand coordinated to the metal ions does not influence the cytotoxic effect of resulting complexes in contrast to metal ions type.

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Recent advances in metal-organic framework-based materials for anti-staphylococcus aureus infection

et al. 2022

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The rapid spread of staphylococcus aureus ( S. aureus ) causes an increased morbidity and mortality, as well as great economic losses in the world. Anti- S. aureus infection becomes a major challenge for clinicians and nursing professionals to address drug resistance. Hence, it is urgent to explore high efficiency, low toxicity, and environmental-friendly methods against S. aureus . Metal-organic frameworks (MOFs) represent great potential in treating S. aureus infection due to the unique features of MOFs including tunable chemical constitute, open crystalline structure, and high specific surface area. Especially, these properties endow MOF-based materials outstanding antibacterial effect, which can be mainly attributed to the continuously released active components and the exerted catalytic activity to fight bacterial infection. Herein, the structural characteristics of MOFs and evaluation method of antimicrobial activity are briefly summarized. Then we systematically give an overview on their recent progress on antibacterial mechanisms, metal ion sustained-release system, controlled delivery system, catalytic system, and energy conversion system based on MOF materials. Finally, suggestions and direction for future research to develop and mechanism understand MOF-based materials are discussed in antibacterial application.

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The effect of sulphur on the antibacterial properties of succinic acid-Cu(II) and mercaptosuccinic acid-Cu(II) MOFs

Cited by 8 publications

References 21 publications

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes

Recent advances in metal-organic framework-based materials for anti-staphylococcus aureus infection

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