The Effect of the Polygonum tinctoria Niram on Atopic Dermatitis in DNCB-Induced Hairless Mice

Abstract

Objectives : The purpose of this study was to investigate the effects of Polygonum tinctoria Niram(PTN) on atopic dermatitis(AD) in hairless mice induced by 2,4-dinitrochlorobenzene(DNCB).Method : They were divided into four group, Nor, Con, 1X and 5X, for evaluating the change of appearance of skin surface, skin hydration, thickness of epidermis and mast cell numbers during 30 days.Results : PTN suppressed symptoms of AD in appearance of skin and increased skin hydration for 1X and 5X. In histopathological examination, 1X and 5X significantly reduced the thickness of epidermis and number of mast cell in dermis. These results suggested that the PTN improved the AD-like symptoms of hairless Mice.

Indigo Pulverata Levis (Chung-Dae, Persicaria tinctoria) Alleviates Atopic Dermatitis-like Inflammatory Responses In Vivo and In Vitro

“…Recently, it has been demonstrated to have excellent clinical efficacy in treating gastrointestinal diseases and AD [ 19 , 20 , 21 ]. Furthermore, CHD contains indigo and indirubin that are effective in treating various diseases, such as bacterial infections, cancer, and inflammation, by affecting the immune system [ 22 , 23 ]. However, the detailed mechanism of action of CHD in treating AD remains unclear.…”