The effect of TPA on restenosis following balloon angioplasty: A study in the atherosclerotic rabbit

Gellman, Joel; Sigal, Stephen L.; Chen, Qingsheng; Esquivel, Ernie; Ezekowitz, Michael D.

doi:10.1016/0735-1097(91)91068-p

Cited by 16 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this model, both carotid arteries are typically used in the same animal (Figure 1). The rat carotid artery is injured either by air desiccation (Gellman et al, 1991;Sarembock et al, 1996) or by balloon endothelial denudation (Au et al, 1992;Clowes et al, 1991;Golden et al, 1990). A 2F Fogarty balloon is advanced through an incision in the external carotid artery to the common carotid artery.…”

Section: Rat Carotid Artery Modelmentioning

confidence: 99%

Preclinical Restenosis Models: Challenges and Successes

Touchard

Schwartz

2006

Toxicol Pathol

View full text Add to dashboard Cite

Coronary artery disease remains a major problem for Western societies. The advent of percutaneous interventions, including stents has brought clinical care to a new level of efficacy, yet problems remain. Restenosis following stenting in human coronary arteries appears at last to be yielding to therapeutic strategies, especially drug eluting stents. Because therapeutic percutaneous coronary intervention is widely dominated by the intracoronary stent, restenosis therapies must include the stented coronary artery. Animal models and in particular the porcine coronary model seem to represent the human coronary artery reaction to stenting. It mimics several clinical conditions including thrombosis and neointimal formation. A key question in the era of intravascular technologies is how well this and other models can predict clinical events. This paper discusses the models and their application.Keywords. Neointima; restenosis; stent; vascular injury INTRODUCTION Research in human coronary atherosclerosis is limited by an inability to control experiments and by the slow temporal lesion development. Fortunately, animal arterial injury models appear to yield comparable results to clinical trials, and can teach about the arterial response to injury. These models have become indispensable for understanding the interaction of the coronary artery with medical devices, and toward understanding neointimal genesis. They can likely function to test safety and efficacy of new devices. In these models the pathophysiologic aspects of disease can be simulated, variables can be controlled, and statistical data accrued in short time periods.Many animal models have been used for restenosis studies. This variety comes because an ideal animal model does not exist. Each animal model has advantages and disadvantages. This chapter discusses the principal animal models described for restenosis studies, their characteristics, advantages and disadvantages compared with humans, and the considerations necessary for proximity to and ideal animal model and study design.

show abstract

Section: Rat Carotid Artery Modelmentioning

confidence: 99%

Preclinical Restenosis Models: Challenges and Successes

Touchard

Schwartz

2006

Toxicol Pathol

View full text Add to dashboard Cite

show abstract

“…Previous animal and preliminary clinical studies [33][34][35] have suggested a lower restenosis rate with the local infusion of urokinase and tPA. Moreover, the recent data from the EPIC trial [17] demonstrating a reduced clinical restenosis rate at 6 mo has further emphasized the importance that thrombus attenuation may play in chronic outcomes.…”

Section: Late Clinical Resultsmentioning

confidence: 99%

Site-specific intracoronary thrombolysis with urokinase-coated hydrogel balloons: Acute and follow-up studies in 95 patients

Glazier¹,

Hirst²,

Kiernan³

et al. 1997

Cathet. Cardiovasc. Diagn.

View full text Add to dashboard Cite

“…Second, a previous study conducted in our laboratory using the same experimental model showed that doses exceeding 15 Gy are necessary to prevent intimal hyperplasia [15]. In addition, the doses we used matched those recommended for animal experiments and also for clinical use (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) [19].…”

Section: Effect Of External Radiation At 20-gy Doses On Cross-sectionmentioning

confidence: 96%

Ionizing Radiation to Prevent Arterial Intimal Hyperplasia At the Edges of the Stent: Induces Necrosis and Fibrosis

Ducasse

Chevalier²,

Cosset

et al. 2006

Journal of Surgical Research

View full text Add to dashboard Cite

The effect of TPA on restenosis following balloon angioplasty: A study in the atherosclerotic rabbit

Cited by 16 publications

References 0 publications

Preclinical Restenosis Models: Challenges and Successes

Preclinical Restenosis Models: Challenges and Successes

Site-specific intracoronary thrombolysis with urokinase-coated hydrogel balloons: Acute and follow-up studies in 95 patients

Ionizing Radiation to Prevent Arterial Intimal Hyperplasia At the Edges of the Stent: Induces Necrosis and Fibrosis

Contact Info

Product

Resources

About