The effect of trisomy 18 on transverse cerebellar diameter

Hill, Lyndon M.; Marchese, Sandra; Peterson, Carol; Fries, Joanne

doi:10.1016/0002-9378(91)90226-h

Cited by 20 publications

(27 citation statements)

References 13 publications

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“…The size of the fetal cerebellum in cases with spina bifida [4] or triso my 18 [5] is smaller than those in normal fetuses. There fore, measurement of the fetal cerebellum should be a use ful diagnostic tool in the detection of cerebellar abnormal ities in utero.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of Fetal Organ Growth Using the Rossavik Growth Model

Hata¹,

Senoh²,

Hata³

et al. 1996

Gynecol Obstet Invest

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Growth of the fetal cerebellum was monitored by transverse cerebellar diameter (CD) from 14 to 39 weeks menstrual age in 125 normal Japanese fetuses. The growth curve for this parameter was determined using a Rossavik growth model [p = c(t)^k+s(t)]. An R² value of 95.5% was obtained for CD. Variability analysis indicated a progressive increase in variability with fetal age for this parameter. Variability data were used with the growth curve model to determine a standard curve for this parameter. This standard curve provides a superior means to evaluate normal fetal cerebellar growth in the fetus and to identify cerebellar abnormalities in utero.

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Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of Fetal Organ Growth Using the Rossavik Growth Model

Hata¹,

Senoh²,

Hata³

et al. 1996

Gynecol Obstet Invest

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“…[2][3][4][5][6][7][8][9][10][11][12][13][14] The cerebellar transverse diameter has been found to be smaller in fetuses with trisomy 18 and spina bifi da. 6,11 Growth of the cerebellar transverse diameter has been found to be unaffected in fetuses with fetal growth restriction and large-for-gestational-age fetuses. 4,8 However, recent studies have shown that the growth of the cerebellar transverse diameter is affected in some fetal growth restrictions.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6][7][8][9][10][11][12][13][14] However, the geometric parameter evaluated in all those studies has been one-dimensional (mainly the cerebellar transverse diameter). [2][3][4][5][6][7][8][9][10][11][12][13][14] The cerebellar transverse diameter has been found to be smaller in fetuses with trisomy 18 and spina bifi da. 6,11 Growth of the cerebellar transverse diameter has been found to be unaffected in fetuses with fetal growth restriction and large-for-gestational-age fetuses.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional sonographic volume measurement of the fetal cerebellum

et al. 2007

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Our findings suggest that a standard curve for fetal cerebellar volume using three-dimensional ultrasound can play a role in the evaluation of normal cerebellar growth in the fetus. However, we do cast doubt on the reliability and reproducibility of cerebellar volume measurement using three-dimensional ultrasound. Further studies involving a larger sample size and another technique (the rotational method with VOCAL) would be needed to confirm these findings.

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“…Fetuses with chromosomal abnormalities show various systemic abnormal findings in ultrasound examination, as well as malformations of the central nervous system . Concerning cerebellar hypoplasia, a central nervous abnormality, some studies have reported association with aneuploidy, in particular, trisomy 18 . According to International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) guidelines, fetal cerebellar evaluation in the second trimester is recommended and widely performed .…”

Section: Introductionmentioning

confidence: 99%