This study aims to analyze the impact of economic growth, education, unemployment, and HDI on poverty in the Special Region of Yogyakarta (DIY) Province during 2015-2021. This study uses panel data linear regression analysis using data from five districts/cities in DIY Province. The Central Bureau of Statistics website was the source of information. The analysis techniques used include a model selection test, stationarity or unit root test, classical assumption test, panel data regression analysis, and hypothesis testing using a trial and coefficient of determination (R2) test. The research findings show that economic growth, education, and unemployment do not significantly affect poverty. In contrast, the Human Development Index shows a significant effect on poverty.