“…As the temperature is increased, the denaturation of collagen occurs. During denaturation, not only the structure but also the hydration of collagen changes, and thus, not surprisingly, thermal denaturation can lead to remarkable property changes in collagenous tissues, such as the mechanical (Aksan and McGrath, 2003;Bass et al, 2004;Chae et al, 2003;Chao et al, 2001;Chen and Humphrey, 1998;Chen et al, 1997Chen et al, , 1998aDiaz et al, 2001;Harris and Humphrey, 2004;Kondo et al, 2005;Spoerl et al, 2004;Wang et al, 2005;Wells et al, 2004), thermal (Davis et al, 2000;Naseef et al, 1997;Siapi et al, 2005;Tsereteli et al, 1997), and optical (Agah et al, 1996;Bosman, 1993;Essenpreis, 1992;Jun et al, 2003;Lin et al, 1996;Pickering et al, 1994;Ritz et al, 2001a,b;Schwarzmaier et al, 1998;Thomsen and Vijverberg, 1993) properties. However, there are comparatively few studies on skin tissue (Le Lous et al, 1985;Melling et al, 2000;Pierce et al, 2004;Reihsner et al, 2000), despite the skin's dermis being mainly composed of collagen.…”