The effect of zinc supplementation on cigarette smoke-induced nephrotoxicity in rats

Abstract

Smoking is known to affect many tissues and systems, mainly the cardiovascular system and the respiratory system (Khanna et al., 2009). Smoke has also recently been reported to have negative effects on renal functions (Özbek, 2012). Epidemiological studies have revealed that smoking is a risk factor for development of nephropathy through different mechanisms. Free oxygen radicals (FOR)-induced nephrotoxicity is one of these mechanisms. Zinc (Zn) is one of the most important antioxidant agents in the fight against FOR-induced injury (Orth, 2002;Pedregosa et al., 2011;Ryua et al., 2011). The positive effects of zinc have been shown in many experimental models in which oxidative stress plays a role, such as ischemia, ulcer and drug toxicity (Murra et al., 2012). The unknown effect of smoke on the renal tissue and methods to prevent effects of the harmful are a novel research area.The aim of our study was to investigate the effect of zincsupplemented diet on the cigarette smoke-induced changes in toll-like receptor (TLR), nuclear factor-kappa B (NFKB) and interleukin (IL) gene expression in renal tissue of rats.

The protective effect of Sider honey and Zinc on imidacloprid induced hepatorenal and hematological toxicity in rats

“…Tissues of liver and kidney were dehydrated in series of alcohol concentrations 80%, 90% and 100%, cleared in xylene, embedded in paraffin wax blocks at 58°C. Sections were cut at 4 microns thickness using rotary microtome and stained with hematoxylin and eosin [28] for histological examination under light microscope.…”