The effectiveness of shear wave elastography in the diagnosis of PTMC

Shang, Hai-Tao; Wu, Bolin; Liu, Zhao; Liu, Ying; Cheng, Wen

doi:10.3233/thc-191895

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…When 36.15kPa, the cutoff value of Emax, was used as the diagnostic criteria, the false positive rate of benign nodules was 19.6% (22cm/112) and the false negative rate of malignant nodules was 27.2% (88/323). Shang et al (11) showed that the internal composition of nodules changes with the increase of nodular volume, and the hardness increases. The results of the present study show that the size of nodules impacted the SWE results.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography

et al. 2022

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ObjectiveTo analyze the ultrasonic characteristics of false-negative and false-positive results of shear wave elastography (SWE) in the diagnosis of thyroid nodules to clarify the influence of nodular characteristics on SWE and to guide the clinical application of SWE.MethodsA total of 435 thyroid nodules from 343 patients with the diagnosis confirmed by surgical pathology were analyzed. Preoperative ultrasonography and SWE were conducted. The conventional ultrasound characteristics of thyroid nodules and the maximum Young’s modulus were recorded. The false negativity and false positivity of SWE for the diagnosis of thyroid nodules were calculated. The ultrasonic characteristics of thyroid nodules with SWE false results were analyzed, and logistic regression analysis was adopted to determine the ultrasonic characteristics associated with SWE false results of thyroid nodules.ResultsAmong 323 malignant nodules, the SWE false negativity was 27.2% (88/323). The false positivity of SWE in 112 benign nodules was 19.6% (22/112). Regression analysis showed that an increase in the nodule volume increased the risk of SWE false-positive results (odds ratio [OR] 3.286; 95% confidence interval [CI]: 1.572–6.871; P = 0.002) and decreased the risk of false-negative results (OR 0.238; 95% CI: 0.115–0.493; P < 0.001). Nodules with coarse calcification had an increased risk of SWE false-positive results compared with those without calcification (OR 5.303; 95% CI: 1.098–25.619; P = 0.038). However, nodules with scattered hyperechoic foci had a reduced risk of SWE false-negative results (OR 0.515; 95% CI: 0.280–0.951; P = 0.034).ConclusionNodular size and calcification were correlated with SWE false results, and the clinical application of SWE should be combined with conventional ultrasound features. Fine needle aspiration or a puncture biopsy should be conducted if necessary.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography

et al. 2022

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“…Many authors reported higher EI in malignant compared with benign nodules [25,26,30,[27][28][29]35,37,31,32,34,33,[40][41][42][43][44][45][46]. During the past few years, less encouraging results have emerged, as two studies reported almost similar EI values for benign and malignant thyroid nodules [47,48].…”

Section: Diagnostic Properties Of Thyroid Swementioning

confidence: 99%

“…Interestingly, one study found higher diagnostic accuracy of SWE in nodules less than 1 cm compared with larger nodules [55]. For the diagnosis of micro-PTC, relatively low cut-off points (around 34.5 kPa) were reported in two studies [31,46].…”

Section: Factors Influencing Diagnostic Accuracymentioning

confidence: 99%

Evaluation of thyroid nodules by shear wave elastography: a review of current knowledge

Swan,

Nielsen,

Bonnema

2021

J Endocrinol Invest

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Purpose: Shear wave elastography (SWE), as a tool for diagnosing thyroid malignancy, has gathered considerable attention during the past decade. Diverging results exist regarding the diagnostic performance of thyroid SWE.Methods: A comprehensive literature review of thyroid SWE was conducted using the terms "Thyroid" and "shear wave elastography" in PubMed.Results: The majority of studies found SWE promising for differentiating malignant and benign thyroid nodules on a group level, whereas results are less convincing on the individual level due to huge overlap in elasticity indices. Further, there is lack of consensus on the optimum outcome reflecting nodule elasticity and the cut-off point predicting thyroid malignancy. While heterogeneity between studies hinders a clinically meaningful meta-analysis, the results are discussed in a clinical perspective with regard to applicability in clinical practice as well as methodological advantages and pitfalls of this technology.Conclusion: Technological as well as biological hindrances seem to exist for SWE to be clinically reliable in assessing benign and malignant thyroid nodules. Structural heterogeneity of thyroid nodules in combination with operator dependent factors such as precompression and selection of scanning plane are likely explanations for these findings. Standardization and consensus on the SWE acquisition process applied in future studies are needed for SWE to be considered a clinically reliable diagnostic tool for detection of thyroid cancer.

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“…Hence, advanced malignant tumors yield higher elastography values than adenomas and early carcinomas. Another aspect is size, since a large, advanced tumor contains an increased amount of stiffer tissue [27]. In general, this may explain why studies including T3 and T4 tumors report higher accuracy.…”

Section: Discussionmentioning

confidence: 99%

Can Ultrasound Elastography Discriminate between Rectal Adenoma and Cancer? A Systematic Review

Loft

Pedersen

Rahr

et al. 2021

Cancers

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Background: Rectal cancer is a common malignancy. Since the introduction of bowel-screening programs, the number of patients with advanced adenomas and early rectal cancer has increased. Despite improved diagnostics, the discrimination between rectal adenomas and early rectal cancer (i.e., pT1–T2) remains challenging. The purpose of this systematic review was to evaluate the diagnostic performance of endorectal ultrasound (ERUS) elastography in discriminating rectal adenomas from cancer. Method: Using PRISMA guidelines, a systematic search was performed on PubMed, Embase, and MEDLINE databases. Studies evaluating the primary staging of rectal adenomas and cancer using ERUS elastography were included. Results: Six studies were identified; three evaluated the discrimination between adenomas and cancer; two evaluated adenomas and early rectal cancer (i.e., pT1–T2); one evaluated performance on different T categories. All studies reported increased diagnostic accuracy of ERUS elastography compared to ERUS. Sensitivity, specificity and accuracy ranged 0.93–1.00, 0.83–1.00 and 0.91–1.00, respectively, when discriminating adenomas from cancer. In the differentiation between adenomas and early rectal cancer, the sensitivity, specificity and accuracy were 0.82–1.00, 0.86–1.00 and 0.84–1.00, respectively. Conclusion: Elastography increases the accuracy of ERUS and may provide valuable information on malignant transformation of rectal lesions.

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The effectiveness of shear wave elastography in the diagnosis of PTMC

Cited by 10 publications

References 8 publications

Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography

Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography

Evaluation of thyroid nodules by shear wave elastography: a review of current knowledge

Can Ultrasound Elastography Discriminate between Rectal Adenoma and Cancer? A Systematic Review

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