The effects and potential applications of concentrated growth factor in dentin–pulp complex regeneration

Li, Zixia; Liu, Liu; Wang, Liu; Song, Dongzhe

doi:10.1186/s13287-021-02446-y

Cited by 37 publications

(24 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the area of dentistry, (CGF) has several applications, including the dentin–pulp complex regeneration [ 48 ], defects of periodontium [ 37 ], alveolar osteitis treatment [ 27 ], ridge augmentation surgeries, recession coverage, sinus lift, cystectomy, mixed with autologous bone graft and also used as a membrane during dental implantation, etc [ 21 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized controlled clinical study

et al. 2022

View full text Add to dashboard Cite

Background The surgical extraction of impacted third molars is one of the most common procedures in oral and maxillofacial surgery, which associated with several postoperative complications. The aim of this clinical trial was to estimate the implication of concentrated growth factor (CGF) on postoperative sequelae after the completely impacted lower third molar extraction. Materials and methods A total of 74 sides of 37 participants who had completely bilateral impacted lower third molars were enrolled in this split-mouth, randomized single‑blind, clinical trial. Surgical extraction was undertaken on both sides of the mandible. Randomization was achieved by opaque, sealed envelopes. The postoperative outcomes including wound healing, swelling and pain were clinically assessed at different-time intervals(1st, 3rd and 7th days). A p-value < 0.05 was considered statistically significant. Results The wound healing index was significantly better in the test sides (P = 0.001). Regarding the facial swelling, the test sides had significantly less values than the control sides, particularly on the 1st (1.01 ± .57 vs. 1.55 ± .56) and 3rd days (1.42 ± 0.8 vs. 2.63 ± 1.2) postoperatively. Nonetheless, the swelling was disappeared within the 7th day in both sides. The pain scores of visual analog scale were no a statistically significant difference between both sides on the 1st day, meanwhile, the pain scores were significantly lower in the test sides compared with the control sides, especially on the 3rd (P = 0.001) and 7th days (P < 0.001) postoperatively. Conclusion The application of CGF following the surgical extraction of lower third molar has accelerated the healing of soft tissues as well as reduced postoperative sequelae such as swelling and pain. Therefore, the CGF could be promoted among clinicians during the lower third molar surgical extraction. Trial registration: This study was registered with the TCTR identification number TCTR20210325002 on 25/03/2021 at Thai Clinical Trials Register-Medical Research Foundation of Thailand (MRF). Also it was ethically approved from the institutional ethics committee at the Hospital of Stomatology, Xian Jiaotong University, Xian, China (No: 032), and has been conducted in accordance to the guidelines of the declaration of Helsinki. Written informed consent was obtained from all participants in the study.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized controlled clinical study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Recent data suggests that recently discovered concentrated growth factor can be used to stimulate proliferation and mineralization of dental pulp cells [ 83 ], in addition to its known ability modulate stemness and function in bone marrow stromal cells [ 156 ], periodontal ligament cells [ 157 ], DPSCs [ 158 ] and mesenchymal stem cells [ 156 ]. Concentrated growth factor, containing many important individual growth factors including PDGF, FDF, TGF-beta, VEGF and IGF, is known to impact many cell processes important in regenerative endodontics including adhesion, proliferation, migration, differentiation and local remodeling and angiogenesis [ [156] , [157] , [158] , [159] , [160] ]. In their study, Tian et al demonstrated concentrated growth factor could be used to improve the migration, proliferation and mineralization of dental pulp cells [ 83 ].…”

Section: Tooth Structurementioning

confidence: 99%

Cells and material-based strategies for regenerative endodontics

Siddiqui

Acevedo‐Jake

Griffith

et al. 2022

Bioactive Materials

View full text Add to dashboard Cite

“…The authors noticed that BMP-2 is released slowly for at least 7 days in CGF and L-PRF. Finally, Li et al [127] summarized that CGF stimulates proliferation of different types of mesenchymal stem cells, including DPSCs, PDLSCs, as well as human mesenchymal stem cells (hTERT-E6/E7) in a dose-dependent manner.…”

Section: Mesenchymal Stem Cells and Platelet Concentratesmentioning

confidence: 99%

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: A Narrative Review

et al. 2021

View full text Add to dashboard Cite

Platelet concentrates have been widely used in regenerative medicine, including endodontics. The aim of this manuscript was to assess critically the efficacy of PRF in the treatment of endodontic periapical lesions in adult patients on the basis of the literature. The PICO approach was used to properly develop literature search strategies. The PubMed database was analyzed with the keywords: “((PRP) OR (PRF) OR (PRGF) OR (CGF)) AND (endodontic) AND ((treatment) OR (therapy))”. After screening of 155 results, 14 articles were included in this review. Different types of platelet concentrates are able to stimulate the processes of proliferation and differentiation of mesenchymal stem cells. Platelet rich fibrin (PRF) releases growth factors for at least 7 days at the application site. Growth factors and released cytokines stimulate the activity of osteoblasts. Moreover, the release of growth factors accelerates tissue regeneration by increasing the migration of fibroblasts. It was not possible to assess the efficacy of PRF supplementation in the treatment of endodontic periapical lesions in permanent, mature teeth with closed apexes, due to the lack of well-designed scientific research. Further studies are needed to analyze the effect of PRF on the healing processes in the periapical region.

show abstract

The effects and potential applications of concentrated growth factor in dentin–pulp complex regeneration

Cited by 37 publications

References 69 publications

Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized controlled clinical study

Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized controlled clinical study

Cells and material-based strategies for regenerative endodontics

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: A Narrative Review

Contact Info

Product

Resources

About