The effects of 8-OH-DPAT and (�)-pindolol on isolation-induced ultrasonic vocalizations in 3-, 10-, and 14-day-old rats

Gestational exposure to the organophosphate chlorpyrifos alters social–emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice

“…Interestingly, at least a part of the CPF-induced behavioural alterations reported above could be consistent with CPF-induced changes in serotoninergic functions. Serotonin modulates pup vocalisations through 5HT1A and 1B receptors (Joyce and Carden 1999;Weller et al 2003), aggressiveness both in male and females rodents (de Boer and Koolhaas 2005;Ferrari et al 2005;Holmes et al 2002;Nelson and Chiavegatto 2001) as well as anxiety behaviour (Gross et al 2002). Furthermore, serotonin plays an important role in the processing of information or salience from novel stimuli (Hohmann et al 2007): Alteration in responsiveness to pups observed both in virgin and lactating females or in responsiveness to novel environments (Ricceri et al 2003) could again be consistent with alteration of the central serotoninergic pathways induced by CPF developmental exposure.…”

Selective Breeding for an Infant Phenotype: Rat Pup Ultrasonic Vocalization (USV)

“…Drugs having anxiolytic actions at c-aminobutyric acid (GABA), opioid, and serotonin (5HT1A) receptors potently decrease rates of infant and adult USV in aversive situations. Conversely, antagonists for these systems increase rates of USV (Carden and Hofer, 1990;Carden et al, 1991;Joyce and Carden, 1999;Olivier et al, 1998a, b). Selective serotonin reuptake inhibitors (SSRIs) reduce USV in rat pups (e.g., Joyce and Carden, 1999;Olivier et al, 1998b) in parallel with their effects on USV in adult rats, suggesting similar mechanisms of action.…”

“…Conversely, antagonists for these systems increase rates of USV (Carden and Hofer, 1990;Carden et al, 1991;Joyce and Carden, 1999;Olivier et al, 1998a, b). Selective serotonin reuptake inhibitors (SSRIs) reduce USV in rat pups (e.g., Joyce and Carden, 1999;Olivier et al, 1998b) in parallel with their effects on USV in adult rats, suggesting similar mechanisms of action. Compounds that oppose actions of excitatory amino acids increase USV rates (e.g., NMDA: Kehne et al, 1991;Winslow et al, 1990).…”

Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder

“…However, this effect was evident at a lower dose in young rats (0.125 mg/kg). This higher sensitivity of young subjects has been previously reported for other behavioural responses (Chaouloff et al 1988;Jackson and Kitchen 1989;Johansson-Wallsten and Meyerson 1994;Darmani and Ahmad 1999;Joyce and Carden 1999).The mechanisms underlying the higher sensitivity may rely on an increased number of 5-HT 1A receptors in the hippocampus of young animals (Nyakas et al 1997). These data seem relevant, since this brain structure has been involved in the control of spontaneous alternation (Ellen and Deloache 1968;Richman et al 1986) and OCD (McGuire et al 1994).…”