The effects of acute doses of standardized Ginkgo biloba extract on memory and psychomotor performance in volunteers

Ginkgolide Derivatives for Photolabeling Studies: Preparation and Pharmacological Evaluation

“…16 Several recent studies on healthy volunteers have shown positive effects of EGb 761 on short-term working memory indicating that constituents of G. biloba also influence the brain under physiological conditions. [17][18][19][20] Although the molecular basis for the action of G. biloba TTL constituents on the central nervous system (CNS) is only poorly understood, it is known that the ginkgolides, particularly ginkgolide B (GB, 2), is a potent in vitro antagonist of the platelet-activating factor receptor (PAFR). 21 PAF (1-O-alkyl-2-acetyl-snglycero-3-phosphocholine, Figure 2) is a phospholipid mediator involved in numerous disorders including acute allergy, inflammation, asthma, and ischemic injury.…”

The effect of Oxalis corniculata extract against the behavioral changes induced by 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice

“…The results achieved in this study reveals that different doses of O. corniculata improved memory retention and retrieval significantly (p<0.05). Previous studies on memory retention and retrieval indicated that plants contain large amounts of antioxidants which improve memory, for example, various species of Ocimum (Dokania et al, 2011;Sarahroodi et al, 2012), Saffron (Abe and Saito, 2000), Ginkgo biloba (Rigney et al, 1999), green tea , Magnolia officinalis (Lee et al, 2012), Curcumin (Bishnoi et al, 2008) and Anacyclus pyrethrwn (Sujith et al, 2012). Memory retention and retrieval enhancement by O. corniculata extract could be due to the presence of antioxidants such as flavonoids, cinnamic acid derivatives, coumarins, tocopherols and phenolic acids and their power in scavenge reactive oxygen species.…”

Perfil de utilização de fitoterápicos em farmácias comunitárias de Belo Horizonte sob a influência da legislação nacional

“…e Aesculus hippocastanum -respondem por mais da metade dos fi toterápicos adquiridos nas farmácias. Entre elas, destacase a Ginkgo biloba, cuja utilização tem sido difundida em vários países do mundo (Rigney;Kimber;Hindmarch, 1999). Vários estudos clínicos têm demonstrado que o extrato de Ginkgo biloba pode ser utilizado como agente nootrópico efi caz no tratamento sintomático de defi ciências cognitivas (Schulz;Hansel;Tyler, 2002).…”