“…A number of enzyme preparations, antiseptics, essential oils and surface IDR -Volume 2, Number 1, 2012 active agents have been examined and used for this purpose (3) Over the years, studies have showed that chlorhexidine digluconate (CHX) is the most effective antimicrobial agent used for plaque control (3,4,5). However, the side effects of CHX, primarily staining, taste alteration, and enhancing supragingival calculus formation, limit its potential for long-term use, while promoting interest in research to determine the efficacy of alternative antiplaque agents (2,4,5). The three antimicrobial systems classified as safe and efficacious for the treatment of plaque-induced gingivitis by the FDI plaque subcommittee were cetylpyridinium chloride (CPC), amine/stannous fluoride (AmF/ SnF 2 ), and essential oils (EO) (6).…”