The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes

Haidari, Fatemeh; Zakerkish, Mehrnoosh; Borazjani, Fatemeh; Angali, Kambiz Ahmadi; Foroushani, Golnaz Amoochi

doi:10.1186/s13063-020-04401-3

Cited by 25 publications

(9 citation statements)

References 26 publications

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“…Madani, Ahmady Mahmoodabady[ 20 ] investigation showed a significant reduction in blood glucose with receiving 300 mg/kg/w hydroalcoholic extract of dill supplementation for 10 day (200–250 g) in male diabetic rats. In contrast to our findings, Haidari, Zakerkish[ 21 ] reported significant improvement insulin resistance, insulin, and FPG following 8 weeks of dill supplementation in patient with T2DM. Also, Supplementation of patients with T2DM with 3.3 g/day of dill powder for 8 weeks could significantly reduce levels of insulin.…”

Section: Discussioncontrasting

confidence: 99%

Effect of 6 weeks Pilates training along with dill supplementation on serum concentrations of nesfatin-1, lipocalin-2, and insulin resistance in females with overweight and obesity

Mogharnasi

Sabzevari

Golestani

2022

Journal of Research in Medical Sciences

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Background: This study aimed to investigate the effect of 6 weeks’ pilates training along with dill supplementation on serum concentrations of nesfatin-1, lipocaline-2, and insulin resistance in females with overweight and obesity. Materials and Methods: In this randomized controlled trial study, 45 overweight and obese females are randomly assigned to four groups: Pilates training + dill group (PDG) ( n = 12), pilates training + placebo group (PPG) ( n = 11), dill supplementation group (DG) ( n = 11), and placebo group (PG) ( n = 11). Participants of PDG and PPG performed pilates training for 6 weeks (60 min, 3 sessions per week). PDG and DG received dill tablet (three times a day, 6 weeks). Anthropometric measurements, glycemic markers, and blood samples were assessed before (pretest) and after (posttest) 6 weeks of intervention. Results: Results showed a significant increase in serum concentrations of nesfatin-1 in PDG compared to pretest ( P = 0.001). Differences in the serum concentrations of nesfatin-1 in PDG were greater than PPG, DG, and PG ( P = 0.01). Furthermore, results found in significant reduction in serum concentrations of lipocalin-2, body mass index (BMI), and waist-hip ratio (WHR) in PDG, PPG, and DG as compared to pretest ( P > 0.05). Fasting glucose plasma (FGP) was significantly decreased in all three intervention groups PDG ( P < 0.001), PPG ( P < 0.001), and DG ( P < 0.001) as compared to pretest. Differences in FGP were significantly higher in PDG than PPG, DG, and PG ( P = 0.001). A significant reduction was found for insulin only in PDG after 6 weeks of intervention as compared to pretest ( P = 0.03). Insulin resistance significantly decreased in PDG ( P = 0.03) and PPG ( P = 0.04) as compared to pretest. Body fat percent (BFP) was significantly decreased in PDG ( P = 0.003), PPG ( P = 0.006), and DG ( P = 0.01). However, there were no significant inter-group differences in insulin resistance, insulin, serum concentrations of lipocalin-2, BMI, BFP, and WHR after 6 weeks of Pilates training along with dill supplementation ( P > 0.05). Conclusion: We concluded that 6 weeks of Pilates training along with dill may be beneficial for improvements in serum concentrations of nesfatin-1 and FGP.

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Section: Discussioncontrasting

confidence: 99%

Effect of 6 weeks Pilates training along with dill supplementation on serum concentrations of nesfatin-1, lipocalin-2, and insulin resistance in females with overweight and obesity

Mogharnasi

Sabzevari

Golestani

2022

Journal of Research in Medical Sciences

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“…Previous studies [ 11 , 17 ] have established that the hydroalcoholic extract is more useful than the extracts obtained other fractions of plant. In agreement with the previous literature [ 29 , 30 ], our results showed no significant differences in FBS levels.…”

Section: Discussionsupporting

confidence: 94%

Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models

Abbasi¹,

Goodarzi²,

Tayebinia³

et al. 2021

Metabolism Open

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Background High-fat high-cholesterol diet induces a phenotype similar to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in humans. In NAFLD and NASH, cholesterol and bile acid metabolisms are impaired to accumulate lipids and toxic bile acids along with cholestatic hepatic damage. Recently, the use of herbal-derived cholesterol lowering products has attracted much attention as possible therapeutic strategies for NAFLD. Hence, the aim of this study was to determine the effects of an Anethum graveolens (dill) on liver cholesterol 7 alpha-hydroxylase and liver fat accumulation in rats. Method Thirty-six rats were randomly divided into 6 groups (n = 6) and received normal diet (ND) or a mixture of chow diet+2% cholesterol+0.5% cholic acid + 20% corn oil as high cholesterol/fat (HC–HF) diet (NAFLD model). Animals were also treated daily with dill tablet or dill extract (300 mg/kg). At the end of the 30 days experiments, serum and liver lipid profile and liver total antioxidant capacity were determined. Cholesterol 7 alpha-hydroxylase mRNA and protein expression levels were determined in the liver and histopathological changes in liver tissues were analyzed by microscope. Results Lipid profiles significantly decreased in dill treated groups (p < 0.05). Liver total antioxidant capacity significantly (p < 0.05) increased and MDA levels markedly (p < 0.05) reduced both in dill tablet and dill extract treated groups (p < 0.05). Both types of treatments caused significant increases in liver cholesterol 7 alpha-hydroxylase gene expression (p < 0.05). Histopathological examinations showed that treatment with dill normalized the hypercholesterolemia-induced changes in liver histology. Conclusion Administration of dill significantly reduced liver fat, oxidative stress and increased cholesterol 7 alpha-hydroxylase enzyme at the both mRNA and protein levels. Dill extract was found more effective than its commercially available tablet.

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“…Anethum graveolens significantly reduced fasting insulin (as insulin sensitizer; −2 mIU/L; −3 to −1), insulin resistance (−0.9; −1.8 to −0.1), and LDL-C (−10 mg/dl; −19 to −2) (see Figure 5 ). ( Mobasseri et al, 2014 ; Haidari et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

et al. 2022

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Introduction: Many Ayurvedic medicines have the potential for managing type 2 diabetes mellitus (T2DM), with previous systematic reviews demonstrating effectiveness and safety for specific Ayurvedic medicines. However, many of the reviews need updating and none provide a comprehensive summary of all the Ayurvedic medicines evaluated for managing T2DM.Objective: The objective of this systematic review was to evaluate and synthesize evidence on the effectiveness and safety of Ayurvedic medicines for managing T2DM.Inclusion criteria: Published and unpublished RCTs assessing the effectiveness and safety of Ayurvedic medicines for managing T2DM in adults.Methods: The JBI systematic review methodology was followed. A comprehensive search of sources (including 18 electronic databases) from inception to 16 January 2021 was made. No language restrictions were applied. Data synthesis was conducted using narrative synthesis and random effects meta-analyses, where appropriate. Pooled results are reported as mean differences (MD) with 95% confidence intervals (CI).Results: Out of 32,519 records identified from the searches, 219 articles were included in the systematic review representing 199 RCTs (21,191 participants) of 98 Ayurvedic medicines. Overall, in the studies reviewed the methodology was not adequately reported, resulting in poorer methodological quality scoring. Glycated hemoglobin (HbA1c) was reduced using Aegle marmelos (L.) Corrêa (MD -1.6%; 95% CI −3 to −0.3), Boswellia serrata Roxb. (−0.5; −0.7 to −0.4), Gynostemma pentaphyllum (Thunb.) Makino (−1; −1.5 to −0.6), Momordica charantia L. (−0.3; −0.4 to −0.1), Nigella sativa L. (−0.4; −0.6 to −0.1), Plantago ovata Forssk. (−0.9; −1.4 to −0.3), Tinospora cordifolia (Willd.) Hook.f. and Thomson (−0.5; −0.6 to −0.5), Trigonella foenum-graecum L. (−0.6; −0.9 to −0.4), and Urtica dioica L. (−1.3; −2.4 to −0.2) compared to control. Similarly, fasting blood glucose (FBG) was reduced by 4–56 mg/dl for a range of Ayurvedic medicines. Very few studies assessed health-related quality of life (HRQoL). Adverse events were not reported in many studies, and if reported, these were mostly none to mild and predominately related to the gastrointestinal tract.Conclusion: The current evidence suggests the benefit of a range of Ayurvedic medicines in improving glycemic control in T2DM patients. Given the limitations of the available evidence and to strengthen the evidence base, high-quality RCTs should be conducted and reported.

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The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes

Cited by 25 publications

References 26 publications

Effect of 6 weeks Pilates training along with dill supplementation on serum concentrations of nesfatin-1, lipocalin-2, and insulin resistance in females with overweight and obesity

Effect of 6 weeks Pilates training along with dill supplementation on serum concentrations of nesfatin-1, lipocalin-2, and insulin resistance in females with overweight and obesity

Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

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