The effects of Arnebia euchroma ointment on second-degree burn wounds: a randomized clinical trial

Nasiri, Ebrahim; Hosseinimehr, Seyed Jalal; Hosseinzadeh, Ahmad; Azadbakht, Mohammad; Âkbari, Jafar; Azadbakht, M

doi:10.1016/j.jep.2016.05.029

Cited by 43 publications

(39 citation statements)

References 27 publications

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“…A similar antinociceptive result had already been described for silver sulfadiazine 1% cream in the same model in rats (Silva et al, 2013). Silver sulfadiazine also showed positive results in these tests, which agrees with its analgesic effect described in the clinic (Nasiri et al, 2016;Shahzad and Ahmed, 2013). Although many studies demonstrated the adverse effects related to the silver sulfadiazine use, this treatment still being indicated to reduce the burn lesions (Andersson et al, 2008;Irimia et al, 2011;Labuz and Machelska, 2013).…”

Section: Discussionsupporting

confidence: 86%

Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats

Antoniazzi

Prá

Ferro

et al. 2018

European Journal of Pharmaceutical Sciences

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Thermal injury promotes tissue inflammation and pain, which is difficult to control. Different peripheral mechanisms seem to be involved in burn pain, such as free radical-induced damage, but further study is still needed to understand how oxidant substances induced nociceptor sensitization. The transient receptor potential ankyrin 1 (TRPA1) is an ion channel activated by oxidants substances, and it could be sensitized after tissue inflammation. This study evaluated the TRPA1 involvement in nociception and inflammation produced by a thermal injury model. Male Wistar rats were used. The concentration of the TRPA1 antagonist (HC-030031, 0.05%) on base cream was chosen using allyl isothiocyanate intraplantar test. Then, the base cream containing HC-030031 was tested on the thermal injury model (induced by warm water immersion of hind paw, under anesthesia), and silver sulfadiazine (1%) was used as a positive control. Cream treatments on the hind paw were done daily (200 mg/paw) for 6 days after thermal injury. Also, nociception (static and dynamic mechanical allodynia, heat allodynia, and spontaneous pain) or edema were evaluated. On day 6, inflammatory and oxidative parameters were assessed. The base cream containing HC-030031 produced antinociceptive and anti-inflammatory effects (reduced the edema and inflammatory cells infiltration) and decreased the levels of hydrogen peroxide, or superoxide dismutase and NADPH oxidase activities after thermal injury. Thus, this study showed the involvement of the TRPA1 receptor in the nociception and inflammation caused by thermal injury and suggested that TRPA1 antagonists might be useful as novel treatments for pain and inflammation by topical application.

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Section: Discussionsupporting

confidence: 86%

Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats

Antoniazzi

Prá

Ferro

et al. 2018

European Journal of Pharmaceutical Sciences

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“…Compared to other groups, the collagen generated at the area of wound in the 10% AE ointment group was a horizontal high-quality type (20). Examining the effect of AE ointment in a human model, Nasiri et al, concluded that AE ointment was better than SSD in terms of efficiency and low side effects to treat second degree burns (14). Akhoundinasab et al, compared 3 herbal ointments to treat burns in mice, and concluded that the least angiogenesis was observed in the Robasin group that represented the minimum amount of scar, compared with other groups.…”

Section: Discussionmentioning

confidence: 99%

“…It contains the active ingredients of multiple plants including nigrum and rose extracts, ascorbic acid, wax, oleic acid (37% -49%) and linoleic acid (37% -47%) (13). Nasiri et al, suggested Arnebia euchroma (AE) ointment in their study due to its efficiency and low side effects to treat second degree burns (14). In an animal model study on 40 mice, Akhoundinasab et al, described Robasin ointment as an effective agent to treat burns (15).…”

mentioning

confidence: 99%

Effects of Silver Sulfadiazine and Adibderm® Herbal Ointments in Treatment of Patients with Second Degree Burns: A Randomized Clinical Trial

Ala¹,

Bakhtavar²,

Vahdati³

et al. 2018

Trauma Mon

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“…Although a variety of materials can be used to treat acute or chronic skin wounds, the underlying mechanism involves materials that can help establish key interactions with host cells in ways that unlock the patient's innate powers of regeneration (e.g., see Dalac et al. ; Nasiri et al …”

Section: Outlook and Future Directionsmentioning

confidence: 99%

The Critical Role of Cell Homing in Cytotherapeutics and Regenerative Medicine

Wang

et al. 2018

Advanced Therapeutics

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Recent advances in cell science and regenerative therapies mimic the therapeutic effects of patients' own cells when they home to and accumulate at sites of injury. Inspired by stem cell trafficking under in vivo conditions, the facilitation of stem cell homing and the driving of endogenously mobilized mesenchymal stem cells (MSCs) for advanced therapeutics have shown indisputable success in several preclinical studies. In fact, stem cell homing is also relevant for cell transplantation. Ensuring that a sufficient number of transplanted cells arrive at the targeted region is a prerequisite for treatments to be successful, particularly when culture-expanded cells are injected intravenously. In this progress report, the authors discuss the important role of cell homing following i) the delivery of ex vivo-manipulated cellular materials, ii) the transplantation of bone marrow in a bone marrow transplant procedure, and iii) endogenous cell mobilization/recruitment in response to injury and disease. Considering a paradigm shift from in vitro tissue engineering to in situ tissue regeneration, current endeavors and future potential in the topics of chemokine-guided cell homing and the design of cell-comfortable scaffolds that combine both biochemical and biophysical cues for immunomodulation and in situ tissue regeneration are highlighted.

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The effects of Arnebia euchroma ointment on second-degree burn wounds: a randomized clinical trial

Cited by 43 publications

References 27 publications

Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats

Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats

Effects of Silver Sulfadiazine and Adibderm® Herbal Ointments in Treatment of Patients with Second Degree Burns: A Randomized Clinical Trial

The Critical Role of Cell Homing in Cytotherapeutics and Regenerative Medicine

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