The effects of breadfruit leaf (Artocarpus Altilis) extract on fibroblast proliferation in the tooth extraction sockets of Wistar rat

Rinaldi, Darin Hulwani; Kamadjaja, David B.; Sumarta, Ni Putu Mira

doi:10.20473/j.djmkg.v51.i3.p143-146

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Tooth extraction is the removal of a tooth from its socket as a last resort treatment if it has been badly damaged and cannot be preserved [1]. Wounds are a form of tissue damage that can be caused by the results of medical actions, changes in physiological conditions and contact with heat sources.…”

Section: Tooth Extractionmentioning

confidence: 99%

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The Fibroblast Cell Numbers After Tooth Extraction by Topical Application of Egg White Gel Toward Iod Glycerin

Saleh¹,

Puspita²,

Utami³

2022

Proceedings of the International Conference on Sustainable Innovation on Health Sciences and Nursing (ICOSI-HSN 2022)

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Background:The results of the Indonesian Basic Health Research in 2018 stated that the index for tooth extraction reached 7.9%, higher than treatments with fillings (4.3%) and scaling (1.4%). Actions resulting from tooth extraction that are slow to heal can cause complaints including pain, swelling, bleeding, and even infection, so proper post-extraction management is needed to reduce the possibility of complications. The drug that is often used for wound healing is glycerin iodine, but iodine itself has irritating and toxic properties if it enters the blood vessels, so glycerin iodine needs to be given another alternative as an antiseptic or healing agent after tooth extraction. Objectives: This review aimed to determine the bioactive substances and the effect of Gallus domesticus egg white gel in increasing the number of fibroblast cells in the wound healing process after tooth extraction through a literature study from researchers which was used as a reference for making this literature review. Method: Data were obtained by data collection methods related to the study being studied and analyzed descriptively. Results: Several literatures conclude about bioactive substances and the effect of Gallus domesticus egg white gel in increasing fibroblast cells. These literatures discuss the effect of using egg white gel in the wound healing process that can stimulate fibroblast cells, antiviral, antibacterial, and growth factors. Implications: This review is expected to provide information in the health sector, especially in the oral cavity about the potential of Gallus domesticus egg white gel as a traditional medicine for wound healing which is relatively inexpensive, easy to obtain and practical.

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Section: Tooth Extractionmentioning

confidence: 99%

“…Tooth extraction is the removal of a tooth from its socket as a last resort treatment if it has been badly damaged and cannot be preserved [1]. The results of the 2018 Basic Health Research (RISKESDAS) stated that in Indonesia the index for tooth extraction reached 7.9%, higher than treatment with fillings (4.3%) and scaling (1.4%) [2].…”

Section: Introductionmentioning

confidence: 99%

The Fibroblast Cell Numbers After Tooth Extraction by Topical Application of Egg White Gel Toward Iod Glycerin

Saleh¹,

Puspita²,

Utami³

2022

Proceedings of the International Conference on Sustainable Innovation on Health Sciences and Nursing (ICOSI-HSN 2022)

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“…10 Fibroblasts migrate to the wound site and proliferate, resulting in a predominance of their numbers at the wound site. 11 Fibroblasts first significantly create on day three and reach their peak on day seven. 12 Another study stated that the fibroblast formation starts to decrease to normal levels by around day fourteen.…”

Section: Introductionmentioning

confidence: 98%

The effect of Persea americana Mill. seed extract on inflammatory cells and fibroblast formation in tooth extraction socket healing

et al. 2021

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Background: Inflammatory cells and fibroblasts have an essential role in the wound healing process. Persea americana Mill. seed categorises as a waste; it contains rich nutrients that can accelerate wound healing activity. Purpose: This study aims to determine the effect of Persea americana Mill. seed against inflammatory cells and fibroblast formation in tooth extraction socket healing. Methods: Ninety-six Sprague Dawley rats had their lower left molars removed. Forty-eight rats tested for inflammatory cells were divided into four groups: negative control group (IC1), positive control group (IC2), Persea americana Mill. seed extract concentrations of 50% (IE1) and 90% (IE2). Another 48 rats used for fibroblast were divided into three groups: the control group (FC1), Persea americana Mill. seed concentrations of 50% (FE1) and 90% (FE2). The gel was applied to the socket under general anaesthesia. Four rats from each group were decapitated for histopathological tissue preparations with Haematoxylin Eosin (HE) staining on the 3rd, 5th and 7th days for inflammatory cells and the 3rd, 5th, 7th and 14th days for fibroblast formation. The preparations for each research were scored under the microscope at 40x magnification. The obtained data was analysed using the Kruska—Wallis and the Mann—Whitney test. Results: A significant decrease (p<0.05) of inflammatory cells in IE2 on the 5th and 7th day. A significant increase (p<0.05) of fibroblast formation between treatment and control groups and no significant difference (p>0.05) between FE1 and FE2 was based on the interval days. Conclusion: Persea americana Mill. seed extract can decrease the inflammatory cells and accelerate the fibroblast formation in tooth extraction socket healing.

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Potential Analysis of Belimbing Wuluh (Averhoe bilimbi L.) leaf extract on increasing Fibroblasts, TGFß1 expression and density of Collagen fibers in the Periodontal ligament during Orthodontic Tooth Movement

Herniyati,

Harmono,

Nur Rahman

et al. 2024

RJPT

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Background: Orthodontic treatment is a treatment to correct malocclusion. The periodontal ligament plays an important role in preventing recurrence after orthodontic treatment. Fibroblast cells play a role in the regeneration of the periodontal ligament to maintain the stability of orthodontic treatment. Fibroblast cells play a role in the formation of collagen fibers that will connect teeth to bones. TGFß1 is a growth factor that plays a role in inducing the proliferation and transformation of fibroblasts into myofibroblasts and stimulates the accumulation of matrix proteins, including laminin, collagen 1 and 3, and fibronectin. Orthodontic treatment takes a long time so we need a method to speed it up. Belimbingwuluh leaf extract (Averrhoa bilimbi L.) contains antioxidants and anti-inflammatories which are expected to increase the number of fibroblasts and the density of collagen fibers. Objective : To analyze the potential of belimbingwuluh leaf extract in increasing the number of fibroblasts, TGFß1 expression and collagen fiber density during orthodontic tooth movement. Method: using 36 rats divided into 6 groups. The control group was fitted with orthodontic appliances without extracts, and the treatment group was fitted with orthodontic appliances and starfruit leaf extract for 7 days, 14 days and 21 days. An orthodontic appliance in the form of a closed coil spring Ni-Ti was installed to move the maxillary first molars mesially with orthodontic mechanical force. Histological preparations were made on M1 RA teeth with their periodontal ligament, then the tissue was stained with HE to observe fibroblasts, and Trichome Mallory staining for collagen fiber density and immunohistochemical staining to examine TGFß1 expression. Observation of fibroblasts and TGFß1 expression using a microscope and collagen density were observed using a microscope using the Adobe CS 6.0 application. Results: showed a significant increase in the number of fibroblasts, TGFß1 expression and density of collagen fibers in the 7, 14 and 21 day treatment group compared to the control group (p<0.05). Conclusion: BelimbingWuluh leaf extract increases fibroblasts, TGFß1 expression and collagen fiber density in the periodontal ligament during orthodontic tooth movement.

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The effects of breadfruit leaf (Artocarpus Altilis) extract on fibroblast proliferation in the tooth extraction sockets of Wistar rat

Cited by 3 publications

References 9 publications

The Fibroblast Cell Numbers After Tooth Extraction by Topical Application of Egg White Gel Toward Iod Glycerin

The Fibroblast Cell Numbers After Tooth Extraction by Topical Application of Egg White Gel Toward Iod Glycerin

The effect of Persea americana Mill. seed extract on inflammatory cells and fibroblast formation in tooth extraction socket healing

Potential Analysis of Belimbing Wuluh (Averhoe bilimbi L.) leaf extract on increasing Fibroblasts, TGFß1 expression and density of Collagen fibers in the Periodontal ligament during Orthodontic Tooth Movement

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