The effects of cholesterol inclusion on the molecular organisation of bimolecular lipid membranes

Ashcroft, R.G.; Coster, H.G.L.; Laver, Derek R.; Smith, John R. Lindsay

doi:10.1016/0005-2736(83)90338-3

Cited by 56 publications

(31 citation statements)

References 30 publications

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“…Free sterols were accumulated in chilled tomato fruits (Whitaker 1991). The higher free sterol content in stressed soybean shoots in comparison with the control can be explained by the fact that they are membrane stabilizers which, as their relative proportion increases, reduced the mobility of the acyl chains (Ashcroft et al 1983). It was shown that sterols could influence the structural and functional properties of biological membranes (Horvath et al 1981).…”

Section: Resultsmentioning

confidence: 97%

Alteration in growth and some relevant metabolic processes of broad bean plants during extreme temperatures exposure

Hamada

2001

Acta Physiol Plant

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The effect of heat-shock (42 °C) or chilling-shock (5 °C) on growth and some relevant metabolic changes of broad bean (Viciafaba L.) were studied. Both heat and chilling-stress induced a reduction in growth rate, membrane stability and content of photosynthetic pigments (chlorophyll a, b and carotenoids). K + efflux and UV absorbance increased at increasing or decreasing temperature. Considerable variations in the content of cell-wall components (pectin, cellulose, hemicellulose and lignin), cell-wall associated proteins, soluble sugars, starch, total lipids, glycolipids, phospholipids and sterols were induced by extreme temperure.

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Section: Resultsmentioning

confidence: 97%

Alteration in growth and some relevant metabolic processes of broad bean plants during extreme temperatures exposure

Hamada

2001

Acta Physiol Plant

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“…It consists of a polar region of 6 to 10 A thickness (Finean, 1969;Hauser et al, 1981) and a hydrocarbon region containing cholesterol and the acyl chains of phospholipids in a somewhat disordered array (Finean, 1969). These regions can be further subdivided with respect to properties (Jain & Wu, 1977;Ashcroft et al, 1983). If alcohols are to lower the dielectric barrier they must penetrate into the hydrocarbon region.…”

Section: Location Of Alcohols Within the Lipid Bilayermentioning

confidence: 99%

Modification of the erythrocyte membrane dielectric constant by alcohols

1988

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Aliphatic alcohols are found to stimulate the transmembrane fluxes of a hydrophobic cation (tetraphenylarsonium, TPA) and anion (AN-12) 5-20 times in red blood cells. The results are analyzed using the Born-Parsegian equation (Parsegian, A., 1969, Nature (London) 221:844-846), together with the Clausius-Mossotti equation to calculate membrane dielectric energy barriers. Using established literature values of membrane thickness, native membrane dielectric constant, TPA ionic radius, and alcohol properties (partition coefficient, molar volume, dielectric constant), the TPA permeability data is predicted remarkably well by theory. If the radius of AN-12 is taken as 1.9 A, its permeability in the presence of butanol is also described by our analysis. Further, the theory quantitatively accounts for the data of Gutknecht and Tosteson (Gutknecht, J., Tosteson, D.C., 1970, J. Gen. Physiol. 55:359-374) covering alcohol-induced conductivity changes of 3 orders of magnitude in artificial bilayers. Other explanations including perturbations of membrane fluidity, surface charge, membrane thickness, and dipole potential are discussed. However, the large magnitude of the stimulation, the more pronounced effect on smaller ions, and the acceleration of both anions and cations suggest membrane dielectric constant change as the primary basis of alcohol effects.

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“…In addition, there is no perturbing surface, and both the membrane and incorporated functionalities are likely to be close to their native state. The physical stability of these BLMs is very low and much effort has been put on improving the stability of this particular model membrane [36][37][38]. The residues left from solvent inside the bilayer have affected material properties of the bilayer, such as thickness [39], elasticity [40], and electrical properties [41].…”

Section: Black Lipid Membranes (Blm)mentioning

confidence: 99%

Membrane Electrochemistry: Electrochemical Processes in Bilayer Lipid Membrane

Khalid¹

2013

Electrochemistry

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The effects of cholesterol inclusion on the molecular organisation of bimolecular lipid membranes

Cited by 56 publications

References 30 publications

Alteration in growth and some relevant metabolic processes of broad bean plants during extreme temperatures exposure

Alteration in growth and some relevant metabolic processes of broad bean plants during extreme temperatures exposure

Modification of the erythrocyte membrane dielectric constant by alcohols

Membrane Electrochemistry: Electrochemical Processes in Bilayer Lipid Membrane

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