The effects of deanol on cognitive performance and electrophysiology in elderly humans

Marsh, Gail R.; Linnoila, Markku

doi:10.1007/bf00431997

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…Clinical trials to determine the efficacy of DMAE in treating cognitive dysfunction have, overall, resulted in negative findings. Normal or minimally impaired nondemented elders (eleven subjects) showed no benefit after 21 days of treatment with 900 mg DMAE (10.0 mmol) per day (Marsh and Linnoila, 1979). Likewise, DMAE failed to improve cognitive function in patients suffering from Alzheimer's disease in both a double-blind, placebo-controlled trial (27 patients, dose and duration not provided) and an open-label trial (14 patients, 1.8 grams/day, duration not indicated) (Fisman et al, 1981;Ferris et al, 1977; both cited by Ott and Owen, 1998).…”

Section: 0mentioning

confidence: 99%

Glaucopsia in Emergency Department

Uzunget¹,

Kemal²,

Bilir³

et al. 2019

Int J Crit Care Emerg Med

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Executive SummaryNomination Dimethylethanolamine (DMAE) was nominated by the NIEHS for toxicological characterization, including metabolism, reproductive and developmental toxicity, subchronic toxicity, carcinogenicity and mechanistic studies. The nomination is based on the potential for widespread human exposure to DMAE through its use in industrial and consumer products and an inadequate toxicological database. Studies to address potential hazards of consumer (e.g. dietary supplement) exposures, including use by pregnant women and children, and the potential for reproductive effects and carcinogenic effects are limited. DMAE and related ethanolamines appear to interfere with choline uptake and utilization and may also generate nitrosamines. Further studies are recommended to address these data gaps with special attention to pharmacokinetics and the influence of dietary choline. Consideration should be given to whether the bitartrate salt of DMAE (a form commonly used in dietary supplements) or other DMAE derivative is more appropriate than the free base for use in toxicology studies. Nontoxicological DataChemical Identification The principal compounds related to DMAE [108-01-0] that have common commercial uses and are discussed in this report, are DMAE aceglumate [3342-61-8], DMAE p-acetamidobenzoate (an ester) [2811-31-6], DMAE p-acetamidobenzoate (a salt); Deaner  [3635-74-3], DMAE bitartrate [5988 51-2], DMAE dihydrogen phosphate [6909-62-2], DMAE hydrochloride [2498-25-1], DMAE orotate [1446-06-6], DMAE succinate; tonibral [10549-59-4], centrophenoxine; dimethylethanolamine p-chlorophenoxyacetate hydrochloride [3685-84-5], centrophenoxine orotate [27166-15-0], and meclofenoxate; DMAE p-chlorophenoxyacetate [51-68-3].

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Section: 0mentioning

confidence: 99%