The effects of dietary supplementation with n‐3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial

Nielsen, Gunnar Lauge; Faarvang, K L; Thomsen, B.; K, Teglbjaerg; Jensen, Louise Bach; Hansen, Troels Mørk; Lervang, Hans Henrik; Schmidt, Erik Berg; Dyerberg, Jørn; Ernst, Edzard

doi:10.1111/j.1365-2362.1992.tb01431.x

Cited by 125 publications

(58 citation statements)

References 22 publications

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“…Dietary supplementation with n-3 fatty acids has been used as a means of treating rheumatoid arthritis (44,45), multiple sclerosis (46), insulin-dependent diabetes (47), psoriasis, and atopic dermatitis (48). However, such treatments have generally provided only modest improvements in disease severity (44 -48).…”

Section: Discussionmentioning

confidence: 99%

A Novel Long Chain Polyunsaturated Fatty Acid, β-Oxa 21:3n-3, Inhibits T Lymphocyte Proliferation, Cytokine Production, Delayed-Type Hypersensitivity, and Carrageenan-Induced Paw Reaction and Selectively Targets Intracellular Signals

Costabile

Hii

Robinson

et al. 2001

The Journal of Immunology

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A novel polyunsaturated fatty acid (PUFA), β-oxa 21:3n-3, containing an oxygen atom in the β position, was chemically synthesized, and found to have more selective biological activity than the n-3 PUFA, docosahexaenoic acid (22:6n-3) on cells of the immune system. Although β-oxa 21:3n-3 was very poor compared with 22:6n-3 at stimulating oxygen radical production in neutrophils, it was more effective at inhibiting human T lymphocyte proliferation (IC50 of 1.9 vs 5.2 μM, respectively). β-Oxa 21:3n-3 also inhibited the production of TNF-β, IFN-γ, and IL-2 by purified human T lymphocytes stimulated with PHA plus PMA, anti-CD3 plus anti-CD28 mAbs, or PMA plus A23187. Metabolism of β-oxa 21:3n-3 via the cyclooxygenase and lipoxygenase pathways was not required for its inhibitory effects. Consistent with its ability to suppress T lymphocyte function, β-oxa 21:3n-3 significantly inhibited the delayed-type hypersensitivity response and carrageenan-induced paw edema in mice. In T lymphocytes, β-oxa 21:3n-3 inhibited the agonist-stimulated translocation of protein kinase C-βI and -ε, but not -α, -βII, or -θ to a particulate fraction, and also inhibited the activation of the extracellular signal-regulated protein kinase, but not c-Jun NH2-terminal kinase and p38. In contrast, 22:6n-3 had no effects on these protein kinase C isozymes. The increase in antiinflammatory activity and loss of unwanted bioaction through the generation of a novel synthetic 22:6n-3 analogue provides evidence for a novel strategy in the development of anti-inflammatory agents by chemically engineering PUFA.

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Section: Discussionmentioning

confidence: 99%

A Novel Long Chain Polyunsaturated Fatty Acid, β-Oxa 21:3n-3, Inhibits T Lymphocyte Proliferation, Cytokine Production, Delayed-Type Hypersensitivity, and Carrageenan-Induced Paw Reaction and Selectively Targets Intracellular Signals

Costabile

Hii

Robinson

et al. 2001

The Journal of Immunology

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“…Indeed, the concentration of CRP was significantly negatively correlated with the proportion of DHA in the membranes of granulocytes of patients undergoing coronary angiography [59]. Fish oil (3.6 g EPA plus DHA/day for 12 weeks) significantly lowered (by 20 %) plasma CRP concentrations in patients with rheumatoid arthritis, who have elevated concentrations [60].…”

Section: C-reactive Proteinmentioning

confidence: 99%

Polyunsaturated fatty acids and inflammation

Calder¹

2006

Prostaglandins, Leukotrienes and Essential Fatty Acids

550

416

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“…The evidence that the intake of saturated fatty acids and cholesterol are causally related to atherosclerotic cardiovascular disease is convincing. Thus the oil of M. myristica, because of its high level of unsaturated fatty acid is likely to reduce coronary heart disease if consumed Nielsen et al 1992; Thompson et al 1993). M. myristica seed oil was characterized by a polyunsaturated/saturated (P/S) ratio of 2.18.…”

Section: Fatty Acidsmentioning

confidence: 99%

Short-term Toxicological Evaluation of Monodora myristica Seed Oil

Ajayi¹

2013

IOSR-JESTFT

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The effects of dietary supplementation with n‐3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial

Abstract: Dietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.

Cited by 125 publications

References 22 publications

A Novel Long Chain Polyunsaturated Fatty Acid, β-Oxa 21:3n-3, Inhibits T Lymphocyte Proliferation, Cytokine Production, Delayed-Type Hypersensitivity, and Carrageenan-Induced Paw Reaction and Selectively Targets Intracellular Signals

A Novel Long Chain Polyunsaturated Fatty Acid, β-Oxa 21:3n-3, Inhibits T Lymphocyte Proliferation, Cytokine Production, Delayed-Type Hypersensitivity, and Carrageenan-Induced Paw Reaction and Selectively Targets Intracellular Signals

Polyunsaturated fatty acids and inflammation

Short-term Toxicological Evaluation of Monodora myristica Seed Oil

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