Due to the fast development of high-speed rail (HSR) around the world, high-speed trains (HSTs) are becoming a strong competitor against airliners in terms of long-distance travel. Compared with airliner cabins, HST cabins have much larger window sizes. When the big windows provide better lighting and view of the scenery, they also have significant effects on the thermal conditions in the cabins due to the solar radiation through them. This study presents a numerical study on the solar radiation on the thermal comfort in a typical HST cabin. The effect of solar radiation was discussed in terms of airflow pattern, temperature distribution and thermal comfort indices. Parametric studies with seven different daytime hours were carried out. The effect of using the roller curtain was also studied. The overall cabin air temperature, especially near passengers, was found to have significantly increased by solar radiation. Passengers sitting next to windows were recorded to have an obvious thermal comfort variation at different hours of the day. To improve the passengers’ comfort and reduce energy consumption during hot weather, the use of a curtain could effectively reduce the solar radiation effect in the cabin environment.