The effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rats

Gao, Wansheng; He, Xiaofu; Li, Yunlong; Wen, Jianguo

doi:10.18632/oncotarget.21718

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…During spinal cord injury, mesenchymal stem cells can be injected into the spinal cord using the subarachnoid space. Studies have shown that erythropoietin can accelerate this migration and repair spinal cord injury (16,17). The function of mesenchymal stem cells and their effect on spinal cord injury are shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Possible Mechanism of Placental Mesenchymal Stem Cell-Derived Neural Cell Transplantation on the Recovery of Neurogenic Bladder Function after Spinal Cord Injury

Yao

Song

2022

Cell Mol Biol (Noisy-le-grand)

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After spinal cord injury, more neurogenic bladder function is caused. The purpose of this article is to investigate the possible mechanism of placental mesenchymal stem cell-derived neural cell transplantation on the recovery of neurogenic bladder function after spinal cord injury. 50 SPF Wistar rats were selected to establish a spinal cord injury rat model and divided into experimental groups and in the control group, 25 animals in each group, the experimental group was transplanted with placental mesenchymal stem cell-derived nerve cells, and the urodynamics and TUNEL positive rate were compared. The results of the study showed that compared with the control group, the maximum bladder capacity and bladder compliance of the experimental group increased significantly (P<0.01), and the bladder basic pressure and urinary leakage pressure decreased (P<0.05). The values of these four items are 2.318ml, 28.892cm H2O, 46.34cm H2O, and 0.1389ml/cm H2O, respectively. It can be seen that the transplantation of neural cells derived from placental mesenchymal stem cells is of great significance for the recovery of neurogenic bladder function after spinal cord injury.

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Section: Introductionmentioning

confidence: 99%

Possible Mechanism of Placental Mesenchymal Stem Cell-Derived Neural Cell Transplantation on the Recovery of Neurogenic Bladder Function after Spinal Cord Injury

Yao

Song

2022

Cell Mol Biol (Noisy-le-grand)

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“…A potentially promising discovery, that requires further investigation, is the utilization of FK1706 to improve post-ETSN nerve regeneration. Its potential benefit in neural regeneration derives from its capacity to raise the activation level of the Raf protein in nerve growth factor (NGF)induced cells in signaling pathways [15,16].…”

Section: Studies Bymentioning

confidence: 99%

End-to-Side Neurorrhaphy Technique: Exploring Neuronal Regeneration to Restore Nerve Function

Oliveira,

Maia,

Galvão

et al. 2024

JAMMR

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Aims: To report the case of a pediatric patient with total left brachial plexopathy (TLBP), exhibiting partially restored motor function and impaired sensitivity, who was treated with the End-to-Side neurorrhaphy (ETSN) technique. Presentation of Case: A 13-year-old female was involved in a car accident. After clinical and imaging evaluation, the diagnostic hypothesis was TLBP with partially restored function and loss of protective sensitivity in the pincer region. A surgical intervention was recommended. Due to case characteristics, ETSN appeared to be the most appropriate technique. Discussion: ETSN is a technique utilized for repairing nerve injuries. It involves suturing the distal end of a transected nerve to the lateral side of a healthy donor nerve, aiming to restore neurons through peripheral plasticity. The regeneration mechanism promoted by this technique shares some similarities with that promoted by standard techniques, with important roles being assigned to Schwann cells (SC), for example. However, this procedure has its own particularities, which still require further investigation. Generally, ETSN cannot replicate the efficacy of model techniques, but remains valid in select cases, such as instances involving nerve injuries exceeding 3-4 cm or in the absence of donor nerves. Therefore, ETSN stands as a choice and deserves consideration. Conclusion: The patient progressed with a good prognosis and recovered protective sensitivity in the pincer region. ETSN is efficient for peripheral nerve injuries with inaccessible proximal trunks or long nerve defects. The discussion surrounding ETSN remains controversial, making this study essential for expanding scientific knowledge.

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“…To circumvent immunosuppression and adverse immunosuppressive toxicity during treatment, the tacrolimus analogues GPI-1046, GPI-1485, and FK1706 were developed [44][45][46]. Studies have shown that FK1706 potently activates the MAPK pathway of nerve growth factor (NGF) and has significant neurotrophic effects by binding FK506 binding protein-52 (FKBP-52) and phospholipase C (PLC) to block inhibition of the MAPK pathway [47].…”

Section: Immunophilinmentioning

confidence: 99%

Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration

Jiang

Xingqin

et al. 2021

Journal of Immunology Research

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Erectile dysfunction (ED) is an important cause of reduced quality of life for men and their partners. Recent studies have found that cavernous nerve injury (CNI) during prostate cancer surgery and other pelvic surgery results in medically induced CNIED in more than 80% of patients. The efficacy of first- and second-line treatment options for ED is poor. A great deal of research has been devoted to exploring new methods of neuroprotection and nerve regeneration to save erectile function in patients with CNIED, especially in patients with cavernous nerve injury after prostate cancer surgery. In addition, such as neuromodulatory proteins, proimmune ligands, gene therapy, stem cell therapy, and the current cutting-edge low-energy shock wave therapy have shown advantages in basic research and limited clinical studies. In the context of today’s modern medicine, these new therapeutic techniques are expected to be new tools in the treatment of cavernous nerve injury erectile dysfunction. This article presents the main causes, mechanisms, and treatment of cavernous nerve injury erectile dysfunction and combines them with new treatment strategies.

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The effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rats

Cited by 5 publications

References 34 publications

Possible Mechanism of Placental Mesenchymal Stem Cell-Derived Neural Cell Transplantation on the Recovery of Neurogenic Bladder Function after Spinal Cord Injury

Possible Mechanism of Placental Mesenchymal Stem Cell-Derived Neural Cell Transplantation on the Recovery of Neurogenic Bladder Function after Spinal Cord Injury

End-to-Side Neurorrhaphy Technique: Exploring Neuronal Regeneration to Restore Nerve Function

Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration

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