The Effects of Flaxseed on Menopausal Symptoms and Quality of Life

Çetişli, Nuray Egelioğlu; Saruhan, Aynur; Kivcak, B

doi:10.1097/hnp.0000000000000085

Cited by 21 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The estrogenic action of certain metabolites of flaxseed suggested a potentially positive effect on these post-menopausal symptoms. In a study of 140 postmenopausal women, menopausal symptoms decreased and the quality of life increased in women who ingested a flaxseed supplemented diet [60]. A particularly large trial (199 women) of an unusually long duration (1 year) on a high dose of flaxseed (40 g per day) reported a significant decrease in menopausal symptoms, but this effect did not differ from the control group that ingested a wheat germ placebo [8].…”

Section: Dietary Flaxseed and Female Hormonal Statusmentioning

confidence: 99%

Dietary Flaxseed as a Strategy for Improving Human Health

et al. 2019

View full text Add to dashboard Cite

Flaxseed is a rich source of the omega-3 fatty acid, alpha linolenic acid, the lignan secoisolariciresinol diglucoside and fiber. These compounds provide bioactivity of value to the health of animals and humans through their anti-inflammatory action, anti-oxidative capacity and lipid modulating properties. The characteristics of ingesting flaxseed or its bioactive components are discussed in this article. The benefits of administering flaxseed or the individual bioactive components on health and disease are also discussed in this review. Specifically, the current evidence on the benefits or limitations of dietary flaxseed in a variety of cardiovascular diseases, cancer, gastro-intestinal health and brain development and function, as well as hormonal status in menopausal women, are comprehensive topics for discussion.

show abstract

Section: Dietary Flaxseed and Female Hormonal Statusmentioning

confidence: 99%

Dietary Flaxseed as a Strategy for Improving Human Health

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Flaxseed contains 700-800 times more lignans than any other plant. lignans have antioxidant, anti-angiogenic, antiviral, antifungal, and antiinflammatory non-hormonal properties which affect cell growth and viability (Cetisli et al, 2015). So, many nutritional, physiological, biochemical, and pharmacological researches focused on the health properties of flaxseed in controlling many chronic disorders like cardiovascular diseases, strokes, cancers, DM and treatment of women's diseases (Jangale et al, 2016).…”

Section: Flaxseedmentioning

confidence: 99%

The Possible Effect of Flaxseed Extract on Letrozole-Induced Polycystic Ovary Rat Model: Correlative Histological and Functional Study

El-Galil

Mohammed

2021

Al-Azhar Medical Journal

View full text Add to dashboard Cite

Background: Polycystic Ovary Syndrome (PCOS) is one of the most common metabolic disorders affecting women in the reproductive age leading to infertility/subfertility. It may occur as a complication of Letrozole (LTZ) therapy in breast cancer patients.Objective: This was a preliminary study to assess the possible protective and/or curative effect of flaxseed extract in a letrozole-induced PCO rat model. Material and Methods:Thirty-six adult female albino rats were divided into five main groups: Group I kept as the control group, Group II (Letrozole-induced PCO group), received letrozole solution (3 mg/kg) orally once daily by gastric tube for 21 days. Group III (combined flaxseed and letrozole group), received aqueous flaxseed extract (500 mg /kg/day) orally one hour before letrozole in the same dose and duration as group II, Group IV (recovery group), received letrozole in the same dose and duration as group II and then left without treatment for the next 4 weeks after PCO induction, Group V (flaxseed-treated group), treated with aqueous flaxseed extract orally once daily for the next 4 weeks after PCO induction. At the end of the experiment, final body weight, ovarian weight, blood glucose, serum antioxidants assay, and sex hormones levels were measured. Also, specimens of ovaries were processed for light and electron microscopic studies. Histomorphometric and statistical analyses were done.Results: letrozole-induced PCO resulted in a significant increase in final body weight, ovarian weight as well as abnormal blood glucose, sex steroids hormone levels, and antioxidant assays. Moreover, numerous ovarian cystic follicles, widespread cytoplasmic vacuolation in the granulosa lutein cells, congested blood capillaries, and increased fibrosis within the ovarian medulla were evident in the PCO group in concomitant with a significant increase in area percentage of collagen fibers. The ultrastructural assessment confirmed these distortions. The protective and curative potential of flaxseed is mostly comparable revealed improvement in MONA M. ABD EL-GALIL AND SHYMAA FATHY MOHAMED 3052 the final body weight, biochemical markers and histological changes, with the protective effect was more pronounced than the curative one. Conclusion and Recommendation:Flaxseed succeeded in ameliorating letrozole-induced polycystic ovary owing to its phytochemicals, antioxidant and anti-inflammatory properties with folliculogenesis potentials. So, it is recommended to use flaxseed as a co-therapy with letrozole to reduce its hyperandrogenic effects.

show abstract

“…A menopausa é um mecanismo natural e fisiológico para as mulheres. Para aumentar a qualidade de vida em termos de saúde física, mental e social, estas mulheres precisam de informações, apoio e acompanhamento regular de um profissional de saúde (12) .…”

Section: Menopausaunclassified

“…Em estudo (12) , os estrogênios de ervas inseridos na dieta das mulheres aumentaram o nível de estrogênio, evitando os sintomas causados pela menopausa. Os fitoestrógenos são produtos químicos que podem agir como um estrogênio natural no corpo humano.…”

Section: Menopausaunclassified

See 1 more Smart Citation

Fitoterapia Como Intervenção Em Saúde Da Mulher: Revisão Integrativa Da Literatura

et al. 2020

View full text Add to dashboard Cite

Objetivo: revisar as publicações científicas disponíveis na literatura que descrevem a fitoterapia como intervenção em saúde da mulher.Método: revisão integrativa da literatura nas bases MEDLINE, CINAHL, Scopus e PUBMED. Adotou-se a questão nordeadora: “Quais evidências disponíveis na literatura descrevem a utilização da fitoterapia como intervenção em saúde da mulher?”. Os descritores utilizados foram: “Phytotherapy”; “Complementary Therapies”; “Women’s Health”. O processo de busca e levantamento dos dados ocorreu em novembro e dezembro de 2018, no município de Redenção-Ceará.Resultados: foram analisados nove artigos, três relataram sobre plantas medicinais utilizadas no tratamento da menopausa, três sobre infertilidade, um sobre infecções ginecológicas e dois sobre distúrbios hormonais.Conclusão: os estudos científicos acerca das plantas medicinais ainda são poucos, sendo fundamental a necessidade de mais estudos e pesquisas acerca da fitoterapia utilizada no tratamento das doenças ginecológicas.

show abstract

The Effects of Flaxseed on Menopausal Symptoms and Quality of Life

Cited by 21 publications

References 14 publications

Dietary Flaxseed as a Strategy for Improving Human Health

Dietary Flaxseed as a Strategy for Improving Human Health

The Possible Effect of Flaxseed Extract on Letrozole-Induced Polycystic Ovary Rat Model: Correlative Histological and Functional Study

Fitoterapia Como Intervenção Em Saúde Da Mulher: Revisão Integrativa Da Literatura

Contact Info

Product

Resources

About