The effects of fucoidan extracts on CCl4-induced liver injury

Abstract

The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against CCl(4)-induced oxidative stress by monitoring the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Female, Sparague-Dowley rats were administered with FE (100 mg/kg daily) for 14 days and CCl(4) on the 15'th day, 12 h before they were sacrificed. The levels of GOT, GPT, ALP and LDH in serum of rats, as well as the levels of MDA, SOD, CAT and GPx in total liver homogenate were analyzed. CCl(4)-treatment was found to increase the levels of GOT, GPT, ALP, LDH and MDA, as well as decrease levels of SOD, CAT and GPx significantly. The pre-treatment of rats with FE, however, suppressed the increment of levels of GOT, GPT, ALP, LDH and MDA, as well as recovered the levels of SOD, CAT and GPx in CCl(4)-treated rats. Moreover there was a significant decrease in incidences of necrosis and cirrhosis in the liver tissue of FE-treated rats. These results implied that FE possessed antioxidant properties against CCl(4)-induced oxidative stress.

Attenuation of CCl4 Induced Oxidative Stress, Immunosuppressive, Hepatorenal Damage by Fucoidan in Rats

“…In the same aspect, Park et al concluded that fucoidan applies anti-inflammatory effects by inhibiting the expression of pro-inflammatory cytokines in vitro and in vivo, together with a restricted antibacterial effect in vivo. Furthermore, fucoidan enhanced the production of pro-inflammatory cytokines, IL-6, IL-8 and TNF-α in human neutrophil and delay neutrophil apoptosis [17][18][19][20][21][22][23][24][25][26].…”

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

“…31) Indeed, it has been reported that fucoidan showed significant antioxidative activity in immune cells, neurons, and the liver. 10,32) Kang et al (2008) have reported that fucoidan showed antioxidative properties by increasing such antioxidative enzymes as SOD and GPx against CCl 4 -induced acute liver injury. 19) In agreement, we observed that fucoidan increased SOD and GPx with concomitant reduction of MDA production in a liver homogenate and the plasma of rats with DMN-induced liver fibrosis.…”

“…10,32) Kang et al (2008) have reported that fucoidan showed antioxidative properties by increasing such antioxidative enzymes as SOD and GPx against CCl 4 -induced acute liver injury. 19) In agreement, we observed that fucoidan increased SOD and GPx with concomitant reduction of MDA production in a liver homogenate and the plasma of rats with DMN-induced liver fibrosis. We investigated whether the anti-oxidative effect of fucoidan on chronic liver fibrosis was mediated by Nrf2 which plays a critical role in maintaining the cellular redox balance.…”

“…17) Fucoidan has recently been reported to reduce liver fibrogenesis by protecting from hepatic cell death and inducing HSC death, 18) as well as showing anti-oxidative properties against CCl 4 -induced acute liver injury. 19,20) Tokita et al and Nakazato et al have reported that fucoidan was absorbed in the intestines and distributed in the liver. The degradation of fucoidan has also occurred in the kidneys.…”

A case–control study on seaweed consumption and the risk of breast cancer

“…Miyeok intake did not show any significant associations with the risk of breast cancer in the present study, a finding which may be due to the low consumption frequency and low variation in miyeok intake among the subjects. However, U. pinnatifida (miyeok) has been reported to suppress mammary tumour growth in rats (25) , while fucoidan and fucoxanthin from U. pinnatifida has antitumour (39,40) and antioxidant activities (41) . Therefore, further studies are needed to investigate the relationship between miyeok intake and breast cancer risk in other research settings including areas with a large variation of miyeok intake.…”