The effects of<i>Nigella sativa</i>extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats

Beheshti, Farimah; Hosseini, Mahmoud; Shafei, Mohammad Naser; Soukhtanloo, Mohammad; Ghasemi, Simagol; Vafaee, Farzaneh; Zarepoor, Leila

doi:10.1179/1476830514y.0000000144

Cited by 55 publications

(36 citation statements)

References 70 publications

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“…Herbal drugs play a key role in the folk medicine due to their protective properties (Iweala et al 2011;Ahmad et al 2013;Beheshti et al 2017). In recent years, an attention has been drawn to various plants and plant-derived compounds for the treatment of kidney diseases (Mousavi 2015;Mohebbati et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Mohebbati

Hosseini

Haghshenas

et al. 2017

Endocrine Regulations

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Objective. We investigated the eff ects of hydroalcoholic extract of Nigella sativa (NS) on renal tissue oxidative damage associated with propylthiouracil (PTU)-induced hypothyroidism during neonatal and juvenile growth in rats.Methods. Pregnant rats were divided into fi ve groups designated as: 1) control; 2) propylthiouracil (PTU); 3) PTU-NS100; 4) PTU-NS200, and 5) PTU-NS400. All mothers except the control group received 0.005% PTU in their drinking water during lactation. Besides PTU, mothers in groups 3-5 received 100, 200, and 400 mg/kg of NS extract. Aft er lactation period, the off spring continued to receive the same experimental treatment for the fi rst 8 weeks of their life. Ten male off springs of each group were randomly selected, blood samples collected, and the kidney tissues removed.Results. Th e serum thyroxin concentration in PTU group was lower than control group and improved by extract. PTU increased the renal malondialdehyde (MDA), while reduced the total thiols concentrations and catalase (CAT) and superoxide dismutase (SOD) activity compared to control group. Administration of 200 and 400 mg/kg of NS extract decreased MDA level, while it increased the total thiols and 400 mg/kg increased CAT and SOD activity in renal tissues compared to PTU group. Serum creatinine and blood urea nitrogen (BUN) in PTU group was higher than in comparison with the control group. 400 mg/kg decreased creatinine, but both 200 and 400 mg/kg improved BUN concentration compared to PTU group.Conclusion. Th e results of this study demonstrate that the hydroalcoholic extract of NS has a protective eff ect on the renal tissue oxidative damage associated with PTU-induced hypothyroidism during neonatal and juvenile growth in rats.

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Section: Discussionmentioning

confidence: 99%

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Mohebbati

Hosseini

Haghshenas

et al. 2017

Endocrine Regulations

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“…Additionally, the reactive oxygen species (ROS) and brain tissues oxidative damage play an important role in learning and memory impairment [44]. The RAS is also proposed to have a crucial implication in induction of ROS [45].…”

Section: Discussionmentioning

confidence: 99%

Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril

Abareshi

Anaeigoudari

Norouzi

et al. 2016

Advances in Medicine

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Introduction. Renin-angiotensin system has a role in inflammation and also is involved in many brain functions such as learning, memory, and emotion. Neuroimmune factors have been proposed as the contributors to the pathogenesis of memory impairments. In the present study, the effect of captopril on spatial memory and synaptic plasticity impairments induced by lipopolysaccharide (LPS) was investigated. Methods. The rats were divided and treated into control (saline), LPS (1 mg/kg), LPS-captopril (LPS-Capto; 50 mg/kg captopril before LPS), and captopril groups (50 mg/kg) before saline. Morris water maze was done. Long-term potentiation (LTP) from CA1 area of hippocampus was assessed by 100 Hz stimulation in the ipsilateral Schaffer collateral pathway. Results. In the LPS group, the spent time and traveled path to reach the platform were longer than those in the control, while, in the LPS-Capto group, they were shorter than those in the LPS group. Moreover, the slope and amplitude of field excitatory postsynaptic potential (fEPSP) decreased in the LPS group, as compared to the control group, whereas, in the LPS-Capto group, they increased compared to the LPS group. Conclusion. The results of the present study showed that captopril improved the LPS-induced memory and LTP impairments induced by LPS in rats. Further investigations are required in order to better understand the exact responsible mechanism(s).

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“…The extraction with ethanol was continued on the residue and then concentrated in a rotary evaporator and kept at -20°C before use. In order to obtain the desired concentrations, the extract rates of 0.5, 1, and 2 g were dissolved in 1000-mL of drinking water, respectively (18). Fifteen grams of the product was added to 250 mL of solvent (ethanol-water 1 to 7) from this plant and placed in water at 100°C for 40 minutes.…”

Section: The Preparation Methods Of Plant Extractionmentioning

confidence: 99%

Enhanced Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells in Insulin-Producing Cells by the Extract of Nigella sativa Seeds

Ranjbaran

Abediankenari

Amiri

2018

Iran Red Crescent Med J

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Background: With regards to the high potential of medicinal plants in the production of biopharmaceuticals, one can rely on the promising prospect of insulin production via plant resources. Objectives: This study was conducted with the aim of using plant extract for insulin-producing cells. Methods: This was a quasi-experimental study using critical case sampling. Six samples were gathered from the umbilical cord (Wharton's jelly) in a governmental university affiliated hospital, Sari, Iran in 2017 after successful isolation of mesenchymal stem cells. Initially, Nigella sativa seeds extraction was performed to prepare the extract for cellular differentiation. Next, dithizone (DTZ) staining was used to evaluate insulin production, and insulin level was examined by the enzyme-linked immunosorbent assay (ELISA). Data were analyzed was analyzed with the SPSS version 16 software using independent sample t-test.

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The effects ofNigella sativaextract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats

Cited by 55 publications

References 70 publications

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril

Enhanced Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells in Insulin-Producing Cells by the Extract of Nigella sativa Seeds

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