The Effects ofPortulaca oleraceaon Hypoxia-Induced Pulmonary Edema in Mice

Abstract

Tan Yue, Wen Xiaosa, Qi Ruirui, Shi Wencai, Xin Hailiang, and Li Min. The effects of Portulaca oleracea on hypoxia-induced pulmonary edema in mice. High Alt Med Biol 16:43-51, 2015-Portulaca oleracea L. (PO) is known as ''a vegetable for long life'' due to its antioxidant, anti-inflammatory, and other pharmacological activities. However, the protective activity of the ethanol extract of PO (EEPO) against hypoxia-induced pulmonary edema has not been fully investigated. In this study, we exposed mice to a simulated altitude of 7000 meters for 0, 3, 6, 9, and 12 h to observe changes in the water content and transvascular leakage of the mouse lung. It was found that transvascular leakage increased to the maximum in the mouse lung after 6 h exposure to hypobaric hypoxia. Prophylactic administration of EEPO before hypoxic exposure markedly reduced the transvascular leakage and oxidative stress, and inhibited the upregulation of NF-kB in the mouse lung, as compared with the control group. In addition, EEPO significantly reduced the levels of proinflammatory cytokines and cell adhesion molecules in the lungs of mice, as compared with the hypoxia group. Our results show that EEPO can reduce initial transvascular leakage and pulmonary edema under hypobaric hypoxia conditions.

Effects of purslane (<i>Portulaca oleracea</i> L.) powder on growth performance, blood indices, and antioxidant status in broiler chickens with triiodothyronine-induced ascites

“…The negative effects of T3 treatment on plasma activities of SOD and GPx were also ameliorated by dietary PP supplementation, but it could not restore the reduced ac-tivities of SOD and GPx towards close the control levels at 49 days of experiment. These results are in accordance with previous studies (Jin et al, 2010;Yue et al, 2015), in which aqueous and alcoholic extracts of purslane improved survivability and antioxidant status of the lung and the brain in hypoxic mice. Similarly, in previous studies, supplementation of dried aerial parts of purslane powder to diet positively affected the antioxidant enzymes activities, decreased oxidative damage to lipids, and improved antioxidant status in healthy broilers (Ghorbani et al, 2013;Sadeghi et al, 2016).…”

“…It is noteworthy that hypoxic broilers develop vascular remodeling in the lungs, which reduces their pulmonary vascular capacity (Wideman et al, 2011). Furthermore, when searching for promising antihypoxic drugs, it was noticed that aqueous and alcoholic extracts of purslane exhibited potent antihypoxic properties and that they improve survivability and antioxidant status of the lung and the brain in hypoxic mice (Jin et al, 2010;Yue et al, 2015).…”

Anti-Asthmatic Effects of Portulaca Oleracea and its Constituents, a Review

“…In another study, ethanol extract of P. oleracea has been shown to protect the lungs of mice exposed to hypoxia due to its antioxidant effects [28]. The ethanol extract of P. oleracea reduced ROS and MDA level in the lung tissue and enhanced the level of GSH and SOD when it was orally (100, 200 and 400 mg/kg) injected [29]. In addition, P. oleracea has been reported to a significant increase in level of glutathione peroxidase (GPx), glutathione- S-transferase (GST) and glutathione reeducates (GR) in hepatic and renal tissues of rats [30].…”

A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities

“…PO is a plant with good nutritional and medicinal potentials that can be used as animal feed and food processing industry [ 11 ]. It has been demonstrated that about 10% of PO ethanolic extract had anti-inflammatory and analgesic activity in comparison with synthetic drugs [ 12 ]. The leaves and seeds of purslane can be used orally or applied topically to mitigate skin allergy [ 13 ].…”