A Pharmacological Review on <i>Portulaca oleracea</i> L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities

Rahimi, Vafa Baradaran; Ajam, Farideh; Rakhshandeh, Hasan; Askari, Vahid Reza

doi:10.3831/kpi.2019.22.001

Cited by 85 publications

(40 citation statements)

References 47 publications

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“…Some studies have shown the utilization of purslane extract as antioxidant, anti-inflammation, antitumor and anti-bacteria. 23,24,25,26,27 The chemical content of common purslane ethanol extract includes alkaloid, flavonoid, terpenoid, vitamin, and mineral. The antioxidant content in purslane ethanol extract against free radical formed by reacting with the free radicals stabilizes free radicals and changes free radicals into non-reactive compounds.…”

Section: Resultsmentioning

confidence: 99%

Decreasing the SGPT level of male wistar rats induced by gentamicin with purslane ethanol extract

Saptaningtyas

Rahajoe

Nuroini

2021

J. Teknol. Laboratorium

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Antibiotics from the aminoglycoside group, such as gentamicin, are frequently used for the infection therapy of gram-negative bacteria including Salmonella typhi. Some studies show that gentamicin can cause hepatotoxicity and increase the level of SGPT (serum glutamic pyruvic transaminase). The purpose of this research is to figure out the decreasing SGPT level of male Wistar rats induced by gentamicin with the purslane ethanol extract. This research employed a post-test only control group design, utilizing 25 male Wistar rats divided into 5 groups. The normal control group (NorG) was without any treatment, while the positive control (PG) was intraperitoneally injected with gentamicin 60 mg/kg of rat body weight. The treatment groups consisted of P1, P2, and P3 were intraperitoneally injected with gentamicin at the dosage of 60 mg/kg of rat body weight for 7 days and then administered with purslane ethanol extract respectively at the dosage of 200, 300, and 400 mg/kg of rat body weight per oral for 7 days. The analysis on the SGPT level was conducted with the IFCC modification method using chemistry analyzer. One way ANOVA test shows that there were significant differences in SGPT levels among groups. LSD post hoc test shows that purslane ethanol extract at the dosage of 400 mg/kg of rat body weight significantly decreased the SGPT level (p<0.05) when compared to the positive control group. The administration of common purslane ethanol extract at the dosage of 200, 300, and 400 mg/kg of rat body weight can decrease the SGPT level of male Wistar rats induced by gentamicin.

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Section: Resultsmentioning

confidence: 99%

Decreasing the SGPT level of male wistar rats induced by gentamicin with purslane ethanol extract

Saptaningtyas

Rahajoe

Nuroini

2021

J. Teknol. Laboratorium

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“…Qualitative and quantitative tools have been employed to study the phytoconstituents present in various parts of P. oleracea [ 21 , 99 , 100 , 101 , 102 ]. Studies show that it contains many important metabolites that provide health benefits [ 3 , 27 , 99 ]. The chemical composition of purslane varies during its growth stages [ 5 ].…”

Section: Phytochemical Richness Of Purslanementioning

confidence: 99%

“…Antioxidants are very important for human health as they reduce risk of cell damage by free radicals [ 7 ]. Several studies have investigated and proved the antioxidant potential of purslane [ 27 , 30 , 142 , 176 ]. Several compounds have been isolated from purslane and their antioxidant activities have been proved.…”

Section: Ethnopharmacological Potential Of Purslanementioning

confidence: 99%

“…Several studies have confirmed the anti-inflammatory activity of purslane [ 39 , 41 , 206 , 207 , 208 , 209 , 210 ]. It is reported that purslane also suppresses lung inflammation [ 27 ]. Di Cagno et al.…”

Section: Ethnopharmacological Potential Of Purslanementioning

confidence: 99%

“…Recent advancements in the quantitative tools for the analysis of phytochemicals has led to the identification of several hundred metabolites from various parts of the purslane [ 5 , 7 , 10 , 18 , 21 , 22 ]. Using ethnobotanical leads, scientists have tested the efficacy of purslane as a medicinal plant using in vitro as well as in vivo studies and have found impressive results on its pharmacological potential [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. The confirmation of the medicinal uses against the diseases using modern scientific studies provide evidence in support of the ethno medicinal properties of the purslane.…”

Section: Introductionmentioning

confidence: 99%

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A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)

Kumar

Sreedharan

Kashyap³

et al. 2022

Heliyon

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The Portulaca oleracea L. commonly known as purslane is distributed all over the world and easily grows in diverse soil and climatic conditions. It has been traditionally used as a nutritious and ethnomedicinal food across the globe. Various studies have shown that the plant is a rich source of various important phytochemicals such as flavonoids, alkaloids, terpenoids, proteins, carbohydrates, and vitamins such as A, C, E, and B, carotenoids and minerals such as phosphorus, calcium, magnesium and zinc. It is particularly very important because of the presence of a very high concentration of omega-3- fatty acids especially α-linolenic acid, gamma-linolenic acid and linoleic acid, which are not generally synthesized in terrestrial plants. Various parts of purslane are known for ethnomedicinal and pharmacological uses because of its anti-inflammatory, antidiabetic, skeletal muscle relaxant, antitumor, hepatoprotective, anticancer, antioxidant, anti-insomnia, analgesic, gastroprotective, neuroprotective, wound healing and antiseptic activities. Due to multiple benefits of purslane, it has become an important wonder crop and various scientists across the globe have shown much interest in it as a healthy food for the future. In this review, we provide an update on the phytochemical and nutritional composition of purslane, its usage as nutritional and an ethnomedicinal plant across the world. We further provide a detailed account on ethnopharmacological studies that have proved the ethnomedicinal properties of purslane.

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The effects of purslane consumption on glycemic control and oxidative stress: A systematic review and dose–response meta‐analysis

Jafari

Shoaibinobarian

Dehghani

et al. 2023

Food Science & Nutrition

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Purslane (Portulaca oleracea L.) is a herbal remedy with wide range of pharmaceutic properties. Although the beneficial effect of purslane on the treatment of Type 2 Diabetes Mellitus (T2DM) has been shown, there is an inconsistency among the results of previous studies. Therefore, this study is aimed at conducting a systematic review and meta‐analysis on the effect of purslane on glycemic profile and oxidative stress markers. A systematic search was performed in the Scopus, Web of science, PubMed and the Cochrane Library to find articles related to the effect of the purslane on Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC), Fasting Blood Sugar (FBS), Hemoglobin A1c (HbA1c), insulin resistance, Homeostatic Model Assessment for Insulin Resistance (HOMA‐IR) up to September 2022. Among the 611 initial studies that were identified from searching electronic databases, 16 Randomized Clinical Trials (RCTs) involving 1122 participants (557 cases and 565 controls) were included for data analysis. The results of random‐effects modeling demonstrated that purslane consumption significantly reduced FBS (p < .001), MDA (p < .001) and increased TAC (p < .001). However, purslane consumption did not affect HbA1c (p < .109), fasting insulin (p = .298) and HOMA‐IR (p = .382). Meta‐analyses were performed using both the random‐ and fixed‐effects model where appropriate, and I2 index was used to evaluate the heterogeneity. This meta‐analysis study suggests that purslane has beneficial effects on oxidative stress markers and glycemic parameter. Therefore, it may be a promising adjuvant therapy in T2DM because of its benefits and negligible adverse effects.

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A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities

Cited by 85 publications

References 47 publications

Decreasing the SGPT level of male wistar rats induced by gentamicin with purslane ethanol extract

Decreasing the SGPT level of male wistar rats induced by gentamicin with purslane ethanol extract

A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)

The effects of purslane consumption on glycemic control and oxidative stress: A systematic review and dose–response meta‐analysis

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