The effects of inbreeding on testicular sperm concentration in Peromyscus polionotus

Margulis, Susan W.; Walsh, Allison

doi:10.1071/rd01120

Cited by 33 publications

(27 citation statements)

References 25 publications

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“…Previous research in oldfield mice (Peromyscus polionotus) showed the same pattern, with a transient increase in testes size for low levels of f that is eventually reversed at the higher inbreeding levels [32]. However, we failed to detect a negative correlation between proportion of normal sperm and absolute/relative testes size (results not shown) at the f levels considered, so this question deserves further attention.…”

Section: Discussionsupporting

confidence: 62%

“…Another study in captive populations of Mexican wolf (Canis lupus baileyi) [31] found a similar result, although in this case, the comparison involved pooling subjects from different captive populations (f range, 0-0.6). Regarding sperm production, negative [32] and positive [33] relationships between inbreeding and sperm production have been reported.…”

Section: Introductionmentioning

confidence: 96%

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Effects of Genetic Captive-Breeding Protocols on Sperm Quality and Fertility in the White-Footed Mouse1

Malo

Martínez‐Pastor

Alaks

et al. 2010

Biology of Reproduction

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Mice (Peromyscus leucopus noveboracensis) from a captive-breeding program were used to test the effects of three genetic breeding protocols (minimizing mean kinship [MK], random breeding, and selection for docility [DOC]) and inbreeding levels on sperm traits and fertility. Earlier, in generation 8, one DOC replicate went extinct because of poor reproductive success. By generation 10, spermatozoa from DOC mice had more acrosome and midpiece abnormalities, which were shown to be strong determinants of fertility, as well as lower sperm production and resistance to osmotic stress. In addition, determinants of fertility, including male and female components, were assessed in a comprehensive manner. Results showed that the probability (P) of siring litters is determined by sperm number, sperm viability, and midpiece and acrosome abnormalities; that the P of siring one versus two litters is determined by tail abnormalities; and that the total number of offspring is influenced by female size and proportion of normal sperm, showing the relative importance of different sperm traits on fertility. On average, males with 20% normal sperm sired one pup per litter, and males with 70% normal sperm sired eight pups per litter. Interestingly, the proportion of normal sperm was affected by docility but not by relatively low inbreeding. However, inbreeding depression in sperm motility was detected. In the MK group, inbreeding depression not only affected sperm motility but also fertility: An increase in the coefficient of inbreeding (f) of 0.03 reduced sperm motility by 30% and translated into an offspring reduction of three pups in second litters. A genetic load of 48 fecundity equivalents was calculated.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 96%

Effects of Genetic Captive-Breeding Protocols on Sperm Quality and Fertility in the White-Footed Mouse1

Malo

Martínez‐Pastor

Alaks

et al. 2010

Biology of Reproduction

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“…number and abnormalities) have often been associated with inbreeding depression (e.g. Wildt et al 1987;Roldan et al 1998;Margulis and Walsh 2002;Gage et al 2006), we also examined sperm number in the inbred and outbred male offspring.…”

Section: Offspring Life History Traitsmentioning

confidence: 99%

Female choice and the relatedness of mates in the guppy (Poecilia reticulata)

2008

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Several studies suggest that females may offset the costs of genetic incompatibility by exercising pre-copulatory or post-copulatory mate choice to bias paternity toward more compatible males. One source of genetic incompatibility is the degree of relatedness among mates; unrelated males are expected to be genetically more compatible with a female than her relatives. To address this idea, we investigated the potential for inbreeding depression and paternity biasing mechanisms (pre- and post-copulatory) of inbreeding avoidance in the guppy, Poecilia reticulata. Inbreeding resulted in a reduction in offspring number and quality. Females mated to siblings gave birth to significantly fewer offspring compared to females mated to non-siblings and inbred male offspring took longer to reach sexual maturity. There was no evidence of inbreeding avoidance in pre-copulatory behaviors of females or males. Sexual responsiveness of females to courting males and the number of sexual behaviors males directed at females did not decrease as a function of the relatedness of the two individuals. We also tested whether female guppies can use post-copulatory mechanisms to bias sperm usage toward unrelated males by comparing the number of offspring produced by females mated to two of their siblings (SS), two males unrelated to the female (NN), or to one unrelated male and a sibling male (NS). We found that NS females produced a number of offspring not significantly different than what would be expected if fertilization success were halfway between completely outbreeding (NN) and completely inbreeding (SS) females. This suggests that there is no significant improvement in the number of offspring produced by females mating to both related and unrelated males, relative to that which would be expected if sperm from both males were used equally. Our results suggest that female guppies do not discriminate against closely related males or their sperm.

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“…High levels of inbreeding may be a cause of poor semen quality (Wildt et al, 1982;Margulis and Walsh, 2002;Aurich et al, 2003;van Eldik et al, 2006). Using pedigree data and analyses of sperm quality, Maximini et al (2011) showed that inbreeding depression reduced fertility of Fleckvieh (i.e., dual-purpose Simental) bulls.…”

Section: Introductionmentioning

confidence: 98%

Genome-wide mapping and estimation of inbreeding depression of semen quality traits in a cattle population

Ferenčaković

Sölkner

Kapš

et al. 2017

Journal of Dairy Science

112

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Inbreeding depression is known to affect quantitative traits such as male fertility and sperm quality, but the genetic basis for these associations is poorly understood. Most studies have been limited to examining how pedigree- or marker-derived genome-wide autozygosity is associated with quantitative phenotypes. In this study, we analyzed possible associations of genetic features of inbreeding depression with percentage of live spermatozoa and total number of spermatozoa in 19,720 ejaculates obtained from 554 Austrian Fleckvieh bulls during routine artificial insemination programs. Genome-wide inbreeding depression was estimated and genomic regions contributing to inbreeding depression were mapped. Inbreeding depression did affect total number of spermatozoa, and such depression was predicted by pedigree-based inbreeding levels and genome-wide inbreeding levels based on runs of homozygosity (ROH). Genome-wide inbreeding depression did not seem to affect percentage of live spermatozoa. A model incorporating genetic effects of the bull, environmental factors, and additive genetic and ROH status effects of individual single-nucleotide polymorphisms revealed genomic regions significantly associated with ROH status for total number of spermatozoa (4 regions) or percentage of live spermatozoa (5 regions). All but one region contains genes related to spermatogenesis and sperm morphology. These genomic regions contain genes affecting sperm morphogenesis and efficacy. The results highlight that next-generation sequencing may help explain some of the genetic factors contributing to inbreeding depression of sperm quality traits in Fleckvieh bulls.

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The effects of inbreeding on testicular sperm concentration in Peromyscus polionotus

Cited by 33 publications

References 25 publications

Effects of Genetic Captive-Breeding Protocols on Sperm Quality and Fertility in the White-Footed Mouse1

Effects of Genetic Captive-Breeding Protocols on Sperm Quality and Fertility in the White-Footed Mouse1

Female choice and the relatedness of mates in the guppy (Poecilia reticulata)

Genome-wide mapping and estimation of inbreeding depression of semen quality traits in a cattle population

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