2017
DOI: 10.1093/imammb/dqw021
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The effects of interleukin-2 on immune response regulation

Abstract: The immune system has many adaptive and dynamic components that are regulated to ensure appropriate, precise and rapid response to a foreign pathogen. A delayed or inadequate immune response can lead to prolonged disease, while an excessive or under-regulated response can lead to autoimmunity. The cytokine, interleukin-2 (IL-2) and its receptor IL-2R play an important role in maintaining this balance. The IL-2 receptor transduces pSTAT5 signal through both the intermediate and high affinity receptors, which di… Show more

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Cited by 57 publications
(40 citation statements)
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“…Anti-TNF treatments might be an effective treatment against COVID-19, but further experiments are needed. IL2 is an essential protein for T cell proliferation and regulation of immune responses [54,55]. RNAPII is a key protein in virus transcription [56,57].…”
Section: Molecular Dynamics Simulationmentioning
confidence: 99%
“…Anti-TNF treatments might be an effective treatment against COVID-19, but further experiments are needed. IL2 is an essential protein for T cell proliferation and regulation of immune responses [54,55]. RNAPII is a key protein in virus transcription [56,57].…”
Section: Molecular Dynamics Simulationmentioning
confidence: 99%
“…In addition to the Baker model, several other models that have been applied to the study of cytokine dynamics include Seymour & Henderson (2001), Yiu et al (2012, Jarrett et al (2014), Waito et al (2016) and Waters et al (2018). Seymour & Henderson (2001) modelled cytokine concentrations and regulation mediated by cell surface receptors for two specific pro-inflammatory and anti-inflammatory cytokines, IL-1 and IL-10.…”
Section: Deterministic Modelmentioning
confidence: 99%
“…In another ODE model, the unbalanced interaction between several specific proand anti-inflammatory cytokines that induce a cytokine storm is demonstrated by Waito et al (2016). Waters et al (2018) focused their ODE model on IL-2 and its receptor IL-2R in the immune response.…”
Section: Deterministic Modelmentioning
confidence: 99%
“…Bistability in a lineage switch means that the choice of lineage depends on which factor holds an advantage initially (e.g. Waters et al, 2017). A commitment decision can be reversed by a transient forced expression of the transcription factor associated with the alternative genetic programme (Kulessa et al, 1995;Nerlov and Graf, 1998).…”
Section: Lineage Selection and Multilineage Primingmentioning
confidence: 99%