The Effects of Intracanal Irrigants and Medicaments on Dental-Derived Stem Cells Fate in Regenerative Endodontics: An update

Abstract

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Different Approaches to the Regeneration of Dental Tissues in Regenerative Endodontics

“…The intracanal disinfection is considered to be an essential step of regenerative dentistry, due to the fact that infection prevents pulp tissue reparation and regeneration, and also may cause the damage of stem cells in periapical tissues [95,96]. Careful selection of irrigants seems to be significant, because of their various antimicrobial properties, different reaction with tissues, root canal lubrication, and debris removal [97,98]. The most common protocol to control infection is root irrigation with sodium hypochlorite (NaOCl) and EDTA or chlorhexidine, then canal system filling with antibacterial Ca(OH)2 or triple antibiotic paste [99].…”

What the future holds for regenerative endodontics: novel antimicrobials and regenerative strategies

“…Although using topical antibiotic pastes at lower concentrations provided adequate canal disinfection, such mixtures are difficult to prepare and obtain. The argument about their contribution to the global challenge of antimicrobial resistance at such low concentrations is yet to be settled (Ayoub et al, 2020;Yadlapati et al, 2017;Yadlapati et al, 2014).…”

Regenerative endodontic procedure of permanent teeth with incomplete root development after application of a devitalizing agent – a case report

“…Certain conditions are required to achieve this goal: the presence of stem cells, scaffold and growth factors [11]. The vitality, proliferation and differentiation of stem cells from apical papilla (SCAP) have been shown to be easily affected by inflammation, irrigants and medications in culture [12,13]. The use of devitalizing paste in presented case might have caused harmful adverse effects on these cells.…”