The effects of paradoxical sleep deprivation on estrous cycles of the female rats

Antunes, Isabela B.; Andersen, Mônica Levy; Baracat, E C; Tufik, Sérgio

doi:10.1016/j.yhbeh.2005.09.005

Cited by 66 publications

(45 citation statements)

References 37 publications

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“…The most remarkable finding in this study was the clear-cut changeless in periodically varying of serum estradiol levels after SD. This finding is consistent with that reported by Antunes et al [22]. They found that estrus cycle was disturbed and plasma estradiol concentrations were significantly decreased following paradoxical SD.…”

Section: Discussionsupporting

confidence: 93%

Sleep deprivation enhances peripheral serotonin secretion to regulate the large follicle steroidogenesis of rats

Yang

et al. 2015

Taiwanese Journal of Obstetrics and Gynecology

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Section: Discussionsupporting

confidence: 93%

Sleep deprivation enhances peripheral serotonin secretion to regulate the large follicle steroidogenesis of rats

Yang

et al. 2015

Taiwanese Journal of Obstetrics and Gynecology

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“…Our study complements and extends other investigations of gender response to SD (13). In contrast to males, NOD female mice did present lymphopenia, possibly induced by survival mechanisms of disrupted T-cells, supporting the occurrence of sexual dimorphism in the prevalence of diabetes in NOD in most colonies (4), and showing that SD results in distinct immune outcomes, particularly in terms of the number of cell types.…”

supporting

confidence: 87%

“…It has been shown that housing conditions and degree of emotionality interfere with the incidence of diabetes (16). In Swiss females sleep deprived for 24 h, we observed a significant decrease in the number of lymphocytes which remained at low counts during the 96 h of SD, corroborating the effect of SD on steroid hormones in the female reproductive system (13). NOD males are more emotional than NOD females and the less emotional NOD females become diabetic earlier, suggesting that emotionality via neuroendocrine alterations may be a mediating factor that modulates the expression of diabetes (17).…”

supporting

confidence: 83%

Sleep deprivation reduces the lymphocyte count in a non-obese mouse model of type 1 diabetes mellitus

Ruiz¹,

Andersen²,

Zager³

et al. 2007

Braz J Med Biol Res

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The objective of the present study was to determine whether sleep deprivation (SD) would promote changes in lymphocyte numbers in a type 1 diabetes model (non-obese diabetic, NOD, mouse strain) and to determine whether SD would affect female and male NOD compared to Swiss mice. The number of lymphocytes in peripheral blood after 24 and 96 h of SD (by multiple platform method) or equivalent period of time in home-cage controls was examined prior to the onset of diabetes. SD for 96 h significantly reduced lymphocytes in male Swiss mice compared to control (8.6 ± 2.1 vs 4.1 ± 0.7 10 3 /µL; P < 0.02). In male NOD animals, 24-and 96-h SD caused a significant decrease of lymphocytes compared to control (4.4 ± 0.3 vs 1.6 ± 0.5; P < 0.001 and 4.4 ± 0.3 vs 0.9 ± 0.1 10 3 /µL; P < 0.00001, respectively). Both 24-and 96-h SD induced a reduction in the number of lymphocytes in female Swiss (7.5 ± 0.5 vs 4.5 ± 0.5, 4.4 ± 0.6 10 3 /µL; P < 0.001, respectively) and NOD mice (4 ± 0.6 vs 1.8 ± 0.2, 1.2 ± 0.4 10 3 /µL; P < 0.01, respectively) compared to the respective controls. Loss of sleep induced lymphopenia in peripheral blood in both genders and strains used. Since many cases of autoimmunity present reduced numbers of lymphocytes and, in this study, it was more evident in the NOD strain, our results suggest that SD should be considered a risk factor in the onset of autoimmune disorders.

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“…In women, food-intake changes across the menstrual cycle, in part because of changes in estrogen concentrations (37). The effect of sleep loss on the menstrual cycle and estrogen concentrations in humans is unknown; however, in rats, paradoxical (ie, rapid eye movement) sleep deprivation led to a disruption of the estrous cycle and lower estrogen concentrations (38). We did not systematically assess the menstrual cycle phase during the protocol, and women were allowed to use oral contraceptives.…”

Section: Discussionmentioning

confidence: 99%

Sex and race differences in caloric intake during sleep restriction in healthy adults

Spaeth¹,

Dinges²,

Goel³

2014

The American Journal of Clinical Nutrition

100

103

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Background: Evidence indicates that men and African Americans may be more susceptible to weight gain resulting from sleep loss than women and whites, respectively. Increased daily caloric intake is a major behavioral mechanism that underlies the relation between sleep loss and weight gain. Objective: We sought to assess sex and race differences in caloric intake, macronutrient intake, and meal timing during sleep restriction. Design: Forty-four healthy adults aged 21-50 y (mean 6 SD: 32.7 6 8.7 y; n = 21 women, n = 16 whites) completed an in-laboratory protocol that included 2 consecutive baseline nights [10 or 12 h time in bed (TIB)/night; 2200-0800 or 2200-1000] followed by 5 consecutive sleep-restriction nights (4 h TIB/night; 0400-0800). Caloric intake and meal-timing data were collected during the 2 d after baseline sleep and the first 3 d after sleep restriction. Results: During sleep restriction, subjects increased daily caloric intake (P , 0.001) and fat intake (P = 0.024), including obtaining more calories from condiments, desserts, and salty snacks (Ps , 0.05) and consumed 532.6 6 295.6 cal during late-night hours (2200-0359). Relative to women, men consumed more daily calories during baseline and sleep restriction, exhibited a greater increase in caloric intake during sleep restriction (d = 0.62), and consumed a higher percentage of daily calories during late-night hours (d = 0.78, Ps , 0.05). African Americans and whites did not significantly differ in daily caloric intake, increased caloric intake during sleep restriction, or meal timing. However, African Americans consumed more carbohydrates, less protein, and more caffeine-free soda and juice than whites did during the study (Ps , 0.05). Conclusions: Men may be more susceptible to weight gain during sleep loss than women due to a larger increase in daily caloric intake, particularly during late-night hours. These findings are relevant to the promotion of public health awareness by highlighting nutritional risk factors and modifiable behaviors for weight gain related to sleep-wake timing. This trial was registered at clinicaltrials.gov as NCT02128737 and NCT02130791.

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The effects of paradoxical sleep deprivation on estrous cycles of the female rats

Cited by 66 publications

References 37 publications

Sleep deprivation enhances peripheral serotonin secretion to regulate the large follicle steroidogenesis of rats

Sleep deprivation enhances peripheral serotonin secretion to regulate the large follicle steroidogenesis of rats

Sleep deprivation reduces the lymphocyte count in a non-obese mouse model of type 1 diabetes mellitus

Sex and race differences in caloric intake during sleep restriction in healthy adults

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