“…To better understanding the material basis of TCM syndrome, many studies have disclosed the correlation of syndrome differentiation with objective indicators, including endocrine hormone (adrenocorticosteroids, thyroid hormones, prostaglandins), plasma cyclic nucleotides (cAMP, cGMP, and their dynamic balance), as well as energy metabolism situation, 14,15 which have been applied as the evaluation index for TCM treatment. 16,17 However, TCM syndrome is complex, and the syndrome evolution is not always clear. During the HSCT, we found that the changing of TCM syndrome occurred much more rapidly, and the deviation of "Yin" and "Yang" were more obvious, thus suggesting that HSCT can also be an ideal disease model for observing TCM syndrome evolution and verifying the material basis of "Yin", "Yang", as well as "blood stasis" syndrome in our AA patients.…”