The effects of resveratrol on ovarian hyperstimulation syndrome in a rat model

Ozgur, S.; Öktem, M.; Altınkaya, Sündüz Özlem; Öktem, Emel Özalp; Cenksoy, Cahit; Erdem, Özlem; Elbeğ, Şehri; Helvaci, Ayşe; Erdem, Ahmet; Erdem, Mehmet

doi:10.1016/j.tjog.2018.04.010

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…In recent days, studies have been conducted to investigate the protective antioxidant effect of resveratrol on female reproductive system. Previous studies have shown that resveratrol treatment during in vitro oocyte maturation has beneficial effects (Kwak et al 2012;Ozgur et al 2018). Furthermore, resveratrol is protected against aging by decreasing fertility of mice (Liu et al 2013).…”

Section: A B Cmentioning

confidence: 98%

The effect of resveratrol on oxidative ovary-damage induced by methotrexate in rats (Resveratrol oxidative ovary-damage)

Ata

Kulhan²,

Külhan³

et al. 2019

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Methotrexate (MTX) is a commonly used folic acid antagonist for the treatment of neoplasia and some autoimmune diseases. Resveratrol has important anti-inflammatory, antioxidant and immunomodulatory properties. The aim of this study was to investigate the effects of resveratrol on MTX-induced ovary-damage and oxidative stress in rats. We hypothesized that supplement of resveratrol could counteract MTX-induced cytotoxicity in rat ovary. Albino Wistar female rats were randomly divided into three groups: Healthy control (HC), resveratrol + methotrexate (RMTX) and methotrexate (MTX) group. Their ovaries were removed. Biochemical and histopathological methods were utilized for evaluation of the oxidative ovary-damage. MDA was found to be higher but tGSH and SOD were lower in the ovarian tissue of the rat group administered MTX, but it is observed that these ratios are reversed in HC and in RMTX groups. MTX treatment induced ovary damage and especially pre-treatment with resveratrol provided protective effect against this MTXinduced ovary-damaged.

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Section: A B Cmentioning

confidence: 98%

The effect of resveratrol on oxidative ovary-damage induced by methotrexate in rats (Resveratrol oxidative ovary-damage)

Ata

Kulhan²,

Külhan³

et al. 2019

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“…RSV influenced rat sociosexual behaviour (Henry & Witt, 2006). In vivo experiments on rats showed RTV ability to disrupt ovarian cycle (Henry & Witt, 2006; Ortega & Duleba, 2015), to reduce ovarian weight (Ozgur et al, 2018), ovarian follicular growth (Cabello et al, 2015; Macedo et al, 2017) and number of ovarian follicles (Ergenoglu et al, 2015). In cultured ovarian cells it reduced DNA synthesis (Wong, Villanueva, Cress, & Duleba, 2010) and consequent cell proliferation (Basini et al, 2010; Ortega & Duleba, 2015; Sirotkin et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, the inhibitory effects of RSV on reproductive processes suggest that RSV can be potentially applicable for prevention of gonadotropin‐dependent ovarian hyper stimulation (Cabello et al, 2015; Kolesarova et al, 2012; Ozgur et al, 2018), probably via mitigation the stimulatory action of FSH and its mediator, IGF‐I, on basic ovarian cell functions (Sirotkin, Alexa, et al, 2019). Thus, RSV can suppress female reproductive processes and the ovarian response to endogenous and exogenous hormonal stimulators.…”

Section: Resultsmentioning

confidence: 99%

“…There is a growing number of evidences, that RSV can not only regulate basal ovarian cell functions, but also their response to the upstream hormonal regulators. For example, RSV decreased the stimulatory action of gonadotropin on number of rat (Kasap et al, 2016;Ozgur et al, 2018) and mice (Cabello et al, 2015) ovulations. In in vitro experiments, RSV was able to prevent and even invert the stimulatory action of both FSH and IGF-I on porcine ovarian cell proliferation and apoptosis (Sirotkin, Alexa, et al, 2019).…”

Section: Effects Of Rsv On Reproductive Hormonesmentioning

confidence: 99%

“…On the other hand, RSV influence on peripheral and especially on ovarian hormones have been well documented, although the corresponding available information is inconsistent too. Some authors reported that administration of RSV led to reductions in the levels of plasma anti-Mullerian hormone, insulin-like growth factor 1 (IGF-I) (Macedo et al, 2017), insulin (Banaszewska, Wroty nska-Barczy nska, Spaczynski, Pawelczyk, & Duleba, 2016;Cabello et al, 2015) and Vascular endothelial growth factor (VEGF) (Basini et al, 2010;Ozgur et al, 2018). Moreover, a number of studies demonstrate the ability of RSV to suppress the expression of steroidogenic enzymes (Ortega et al, 2012;Cabello et al, 2015;Ortega & Duleba, 2015) and ovarian progesterone (Basini et al, 2010;Wong et al, 2010), testosterone (Banaszewska et al, 2019) and estradiol Kasap et al, 2016) secretion.…”

Section: Effects Of Rsv On Reproductive Hormonesmentioning

confidence: 99%

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Effects of resveratrol on female reproduction: A review

Sirotkin

2021

Phytotherapy Research

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The present review summarizes the current knowledge concerning physiological effects of resveratrol (RSV) with emphasis on the RSV action on female reproductive processes. The review outlines provenance, properties, mechanisms of action, physiological and therapeutic actions of RSV on female reproduction and other physiological processes, as well as areas of possible application of R. This review is based on the search for the related full papers indexed in Medline/Pubmed, Web of Science and SCOPUS databases between the year 2000 and 2021 according to the criteria of preferred reporting items for systematic reviews and meta‐analyses extension for scoping reviews and other related guidelines. The analysis of the available information suggests that RSV has a number of properties which enable its influence on various physiological processes including female reproduction at various regulatory levels via various extra‐ and intracellular signalling pathways. Despite some contradictions and limitations in the available data, they indicate applicability of both stimulatory and inhibitory effects of RSV for control and influence of various reproductive and non‐reproductive processes and treatment of their disorders in phytotherapy, animal production, medicine, biotechnology and assisted reproduction. To establish the clinical efficacy of RSV, further high quality studies are needed.

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