The effects of serum levels, and alterations in the genes of binding protein and receptor of vitamin D on gastric cancer

Vitamin D and gastric cancer: A systematic review and meta-analysis

“…After reading the title and abstract, 746 articles were excluded. After reading the full text, 10 articles were nally included [11][12][13][14][15][16][17][18][19][20] ,The screening owchart is shown in Figure 1. Including 1159 cases of gastric cancer patients, 33387 cases of normal control patients.…”

“…The literature screening process and results are shown in Figure 1. Including 8 case-control studies [13][14][15][16][17][18][19][20] ,2 cross-sectional studies [11,12] .All come from India, Iran, Turkey, South Korea,China and other Asian countries. The basic characteristics and the quality evaluation of the literature are shown in Table 1.…”

“…Among the included 10 studies, only 7 studies [11][12][13][14][15][16][17] compared the serum vitamin D levels of the gastric cancer experimental group and the normal control group, compared 730 cases of gastric cancer with 33387 cases of normal individuals, and conducted Meta on 7 studies. Signi cant heterogeneity was found during analysis (I 2 =99%, P<0.00001).…”

“…We performed Egger test to evaluate publication bias on 7 articles [11][12][13][14][15][16][17] that included control of gastric cancer and normal patients, and nally found that there was no obvious publication bias (P=0.395);We included 6 articles on different clinical stage of gastric cancer patients [12,14,[17][18][19][20] , and the Egger test to evaluate publication bias, no obvious publication bias was found (P=0.685). Evaluation of 6 articles with different degrees of differentiation [12,13,[17][18][19][20] found the difference was statistically signi cant (P=0.055),suggesting publication bias.…”

Vitamin D and Gastric Cancer: A Ray of Sunshine?

“…Likewise, Durak et al observed that FokI and TaqI polymorphisms of the VDR did not correlate with the susceptibility of GC (p > 0.05), yet found a higher number of the t allele of the TaqI variant in the advanced stage GC, suggesting a nexus between the t allele and a poorer prognosis for GC. In their research, authors assert that VDD strongly correlates with increased GC susceptibility, but the gene polymorphism of vitamin D binding protein (VDBP; rs7041) does not [21]. In addition, another investigation discovered that the BsmI polymorphism is strongly related to GC development, particularly in patients with a high BMI, yet ApaI and TaqI are not.…”