1970
DOI: 10.1016/0006-8993(70)90436-1
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The effects of short-term starvation on amino acid content in rat brain during ontogeny

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1975
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Cited by 23 publications
(6 citation statements)
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“…The relative distribution of amino acids among the seven brain regions and the relative proportion of the seven amino acids within a given brain region found in the present study are in general agreement with previous reports (Himwich and Agrawal, 1969;Mourek et al, 1970;Cutler and Dudzinski, 1974). In addition, developmental trends generally agree with previous studies of amino acids in brain or brain regions (Agrawal et al, 1966;Mourek et al, 1970;Davis and Himwich, 1973;Enwonwu and Glover, 1973;Cutler and Dudzinski, 1974;Roach et al, 1974;Kalyanasundaram and Ramanamurthy, 1982). Any discrepancies in development-related trends appear to be due to differences in the ages of animals used in each study.…”
Section: Discussionsupporting
confidence: 94%
See 1 more Smart Citation
“…The relative distribution of amino acids among the seven brain regions and the relative proportion of the seven amino acids within a given brain region found in the present study are in general agreement with previous reports (Himwich and Agrawal, 1969;Mourek et al, 1970;Cutler and Dudzinski, 1974). In addition, developmental trends generally agree with previous studies of amino acids in brain or brain regions (Agrawal et al, 1966;Mourek et al, 1970;Davis and Himwich, 1973;Enwonwu and Glover, 1973;Cutler and Dudzinski, 1974;Roach et al, 1974;Kalyanasundaram and Ramanamurthy, 1982). Any discrepancies in development-related trends appear to be due to differences in the ages of animals used in each study.…”
Section: Discussionsupporting
confidence: 94%
“…The present report of brain region amino acid concentrations in pre-and postweanling control and undernourished rats significantly expands earlier studies (Agrawal et al, 1966;Mourek et al, 1970;Davis and Himwich, 1973;Enwonwu and Glover, 1973;Cutler and Dudzinski, 1974;Roach et al, 1974;Kalyanasundaram and Ramanamurthy, 1982), which were limited largely to analyses of whole brain specimens or to a small number of brain regions. In control rats, several interesting differences were noted when the concentrations of regional amino acids in 17-and 35-day-old rats were compared.…”
Section: Discussionsupporting
confidence: 81%
“…As both tasks require some level of response inhibition, these findings of maturational delays of memory for withholding responses suggest the retarded development of neurotransmitter systems possibly involved with these behaviors. Such an interpretation is consistent with earlier reports of decreased cell number (Bass, 1971 ;Fish & Winick, 1969) and axonal proliferation (Cragg, 1972) in the forebrain, as well as retarded development of indices of cholinergic (Adlard & Dobbing, 1971;Eckhert, Barnes, & Levitsky, 1976), serotonergic and y-aminobutyric acid (CABA) (Mourek, Agrawal, Davis, & Himwich, 1970;Ramanamurthy, 1977;Shoemaker & Bloom, 1977) functioning in undernourished animals.…”
Section: I-hr Retestsupporting
confidence: 92%
“…Such suggestions find support from the altered biochemical milieu of the brain observed in undernourished states. Significant changes in the cerebral content of nucleic acids and pro teins [16,21], lipids [8,31], amino acids [43], as well as abnormal amino acid metabolism and compartmentation [49] have been shown in the undernourished animals. These bio chemical alterations reflect a delay in the growth of neuronal processes [18] as well as maturation of neurone-glia relationships [47], All of these neurochemical changes can ex plain the present electrophysiological findings.…”
Section: Discussionmentioning
confidence: 99%