The effects of sildenafil on rectal sensitivity and tone in patients with the irritable bowel syndrome

Medeiros, Maria Teresa Gonçalves de; Oliveira, R. B.; Santos, Armênio Aguiar dos; Leopoldino, D. M. de; Lima, M. C. Oliveira; Nobre, Rivianny Arrais; Souza, Miguel Angelo N.

doi:10.1111/j.1365-2036.2011.04977.x

Cited by 10 publications

(13 citation statements)

References 34 publications

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“…The findings suggested that various herbal remedies, such as passionflower, may play some role in the alleviation of anxiety [124]. Some target synthetic compounds focusing on depression and anxiety, such as phosphodiesterase 5 inhibitors, have also been proven to be effective in neutralizing radical oxygen species, which may result in the treatment of anxiety-related disorders, such as the irritable bowel syndrome [125]. …”

Section: Introductionmentioning

confidence: 99%

Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment

Xu¹,

Wang²,

Klabnik³

et al. 2014

115

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There is growing evidence that the imbalance between oxidative stress and the antioxidant defense system may be associated with the development neuropsychiatric disorders, such as depression and anxiety. Major depression and anxiety are presently correlated with a lowered total antioxidant state and by an activated oxidative stress (OS) pathway. The classical antidepressants may produce therapeutic effects other than regulation of monoamines by increasing the antioxidant levels and normalizing the damage caused by OS processes. This chapter provides an overview of recent work on oxidative stress markers in the animal models of depression and anxiety, as well as patients with the aforementioned mood disorders. It is well documented that antioxidants can remove the reactive oxygen species (ROS) and reactive nitrogen species (RNS) through scavenging radicals and suppressing the OS pathway, which further protect against neuronal damage caused oxidative or nitrosative stress sources in the brain, hopefully resulting in remission of depression or anxiety symptoms. The functional understanding of the relationship between oxidative stress and depression and anxiety may pave the way for discovery of novel targets for treatment of neuropsychiatric disorders.

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Section: Introductionmentioning

confidence: 99%

Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment

Xu¹,

Wang²,

Klabnik³

et al. 2014

115

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“…As a group, patients with IBS report higher levels of anxiety and depression (Goncalves de Medeiros et al, 2012; Jones, Koloski, Boyce, & Talley, 2011; Orr, Crowell, Lin, Harnish, & Chen, 1997), stress and more co-morbid conditions (Gulewitsch, Enck, Hautzinger, & Schlarb, 2011) suggesting that CPM efficiency may be reduced. In addition, several studies found that IBS patients have dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis as evidenced by either hyper or hyposecretion of cortisol or dysregulation between ACTH and cortisol levels (Chang et al, 2009; Heitkemper et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Conditioned Pain Modulation in Women With Irritable Bowel Syndrome

Jarrett

Shulman

Cain

et al. 2014

Biological Research For Nursing

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Evidence suggests that patients with irritable bowel syndrome (IBS) are more vigilant to pain-associated stimuli. The aims of this study were to compare women with IBS (n = 20) to healthy control (HC, n = 20) women on pain sensitivity, conditioned pain modulation (CPM) efficiency and salivary cortisol levels before and after the CPM test; and examine the relationship of CPM efficiency with gastrointestinal, somatic pain, and psychological distress symptoms in each group. Women, ages 20–42, gave consent, completed questionnaires and kept a symptom diary for 2 weeks. CPM efficiency was tested with a heat test stimulus and cold water condition stimulus in a laboratory between 8 and 10 a.m. on a follicular phase day. Salivary cortisol samples were collected just before and after the experimental testing. Compared to the HC group, women with IBS reported more days with gastrointestinal and somatic pain/discomfort, psychological distress, fatigue, and feeling stressed. During the CPM baseline testing women with IBS reported greater pain sensitivity compared to the HC group. In the IBS group, CPM efficiency was associated with the pain impact (PROMIS) measure, daily abdominal pain/discomfort, psychological distress, in particular anxiety. There was no group difference in salivary cortisol levels. Overall, women with IBS exhibit an increased sensitivity to thermal stimuli. Impaired CPM was present in a subset of women with IBS.

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“…[10][11][12][13][15][16][17][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] The baseline characteristics of included studies are shown in Table 1 22,29 Sphere score in 1 study, 24 and the Beck Anxiety Inventory (BAI) in 1 study. 30 …”

Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

“…A total of six studies were included. 15,17,18,37,38,65 In those studies, healthy-control groups were used for multiple comparisons with the three IBS-subtypes; we divided the healthy-control group into three groups for meta-analysis of three IBS-subtypes alongside healthy controls. Depression levels were significantly higher in IBS-C (SMD = 0.83; 95% CI, 0.61-1.06; I 2 = 0%; P < 0.001), IBS-D (SMD = 0.73; 95% CI, 0.51-0.96; I 2 = 0%; P < 0.001), and IBS with mixed bowel habits (SMD = 0.62; 95% CI, 0.39-0.84; I 2 = 0%; P < 0.001) (Fig.…”

Section: Depression and Anxiety In Irritable Bowel Syndrome-subtypementioning

confidence: 99%

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

Lee

Doo

Choi

et al. 2017

J Neurogastroenterol Motil

177

151

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Background/AimsIrritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls. MethodsWe searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy controls. The primary outcome was a standardized mean difference (SMD) of anxiety and depression levels; subgroup analyses were conducted according to IBS-subtypes. ResultsIn total, 2293 IBS patients and 4951 healthy controls from 27 studies were included. In random effect analysis, depression and anxiety levels were significantly higher in IBS patients (pooled SMD = 0.76; 95% CI, 0.62-0.90; P < 0.001; I 2 = 77.2% and pooled SMD = 0.84; 95% CI, 0.67-1.01; P < 0.001; I 2 = 85.6%, respectively). Both analyses' funnel plots showed symmetry. In meta-regression analysis, heterogeneity was due to the studied region and questionnaire type for both depression and anxiety. In sub-group analyses of IBS-subtype, the pooled SMDs of depression and anxiety levels (IBS with predominant constipation: 0.83 and 0.81, IBS with predominant diarrhea: 0.73 and 0.65, and IBS with mixed bowel habits: 0.62 and 0.75; P < 0.001, respectively) were significantly higher in all IBS-subtypes. ConclusionsThe present meta-analysis showed depression and anxiety levels to be higher in IBS patients than in healthy controls, regardless of IBSsubtype. However, the gender effect on psychological factors among IBS patients could not be determined and should be evaluated in prospective studies.

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The effects of sildenafil on rectal sensitivity and tone in patients with the irritable bowel syndrome

Abstract: SUMMARY Background

Cited by 10 publications

References 34 publications

Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment

Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment

Conditioned Pain Modulation in Women With Irritable Bowel Syndrome

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

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