The effects of single-dose atenolol, labetalol, and propranolol on cardiac and vascular function

Holtzman, Jordan L.; Finley, Denise; Johnson, Bradford; Berry, Donald A.; Sirgo, Mark A.

doi:10.1038/clpt.1986.174

Cited by 16 publications

(1 citation statement)

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“…In contrast, an intravenous infusion of atenolol caused no fall in arterial pressure at 15 minutes and significant falls only after 1 to 3 hours in the case of the diastolic pressure [13]. Similar differences have been found between oral labetalol and atenolol by Holtzman et al [14], who showed that the major mechanism of labetalol's hypotensive effect was by acute vasodilation. In severely hypertensive subjects, labetalol (100 to 125 mg intravenous bolus) was compared with propranolol (10 mg intravenous bolus); within 5 minutes labetalol had had a hypotensive effect which was sustained for 3 hours, whereas propranolol did not decrease the pressure at all [15].…”

Section: Labetalol: Acute Vasodilatory Effects On Blood Pressure In Hsupporting

confidence: 68%

Role of vasobilation in the antihypertensive and antianginal effects of labetalol: Implications for therapy of combined hypertension and angina

Opie

1988

Cardiovasc Drug Ther

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Beta-adrenergic blockade is established therapy in the management of both hypertension and angina pectoris. This review evaluates the use of combined alpha-adrenergic and beta-adrenergic blockade for these conditions, with reference to labetalol. There are three major differences between labetalol and propranolol or similar conventional beta-blockers. First, in the mechanism of the antihypertensive effect, peripheral vasodilation plays a prominent role during the use of labetalol. In particular, acute therapy with labetalol rapidly reduces the blood pressure because of this reduction in the systemic vascular resistance. During prolonged therapy with labetalol over many years, blood pressure remains reduced with a sustained fall in the systemic vascular resistance. Second, in patients with combined hypertension and angina pectoris, fixed doses of labetalol (200 mg twice daily) gave the same blood pressure values, effort tolerance, and nitrate usage as did atenolol 100 mg once daily in a double-blind, double-dummy, crossover study. Labetalol gave higher heart rates at rest and during exercise (both p less than 0.01). The higher heart rate with labetalol could be an advantage in some patients with effort angina and a disadvantage in others. Third, in hypertensive asthmatics, labetalol appears to have a relative bronchosparing effect, when compared with propranolol. The possession by labetalol of beta2-stimulating qualities (intrinsic sympathomimetic activity) may explain part of the dilating effect and the bronchosparing quality. Thus labetalol 1) lowers blood pressure by a mechanism involving vasodilation, 2) has an equiantianginal effect to atenolol yet a higher heart rate, and 3) may be bronchosparing. Differences among various beta-blockers may be important in matching the properties of the beta-blocker chosen to the requirements of the individual patient.

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Section: Labetalol: Acute Vasodilatory Effects On Blood Pressure In Hsupporting

confidence: 68%

Role of vasobilation in the antihypertensive and antianginal effects of labetalol: Implications for therapy of combined hypertension and angina

Opie

1988

Cardiovasc Drug Ther

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Regression of cardiac hypertrophy in hypertensive patients—comparison of Abana with propranolol

et al. 1997

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Interactions between Occupational and Environmental Factors in Toxicology, Hazard Evaluation and Risk Assessment

Gomes

Meek

2009

General, Applied and Systems Toxicology

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Occupational and environmental exposures to toxicants rarely occur in isolation or singly and the potential for multiple exposures occurring with different degrees of overlap and multiple numbers of toxicants is high. Interactions occur when multiple chemicals are present in biological systems at the same time. The nature and the intensity of the interactions vary greatly from individual to individual and are dependent upon a number of factors. Primarily, the interaction response is dependent both upon the chemicals in question and the individual that is exposed. Chemical‐associated factors include mechanisms or modes of action of the chemicals, timing of exposure and dose of exposure. Individual‐associated factors include personal characteristics, lifestyle factors, physiological factors and genetic factors. An integrated systems‐biology approach is necessary to evaluate the exposure, the interaction and the biological response. Newer technologies (omics) could play a significant role in assessing the risk of interaction from exposure to multiple toxins.

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The effects of single-dose atenolol, labetalol, and propranolol on cardiac and vascular function

Cited by 16 publications

References 0 publications

Role of vasobilation in the antihypertensive and antianginal effects of labetalol: Implications for therapy of combined hypertension and angina

Role of vasobilation in the antihypertensive and antianginal effects of labetalol: Implications for therapy of combined hypertension and angina

Regression of cardiac hypertrophy in hypertensive patients—comparison of Abana with propranolol

Interactions between Occupational and Environmental Factors in Toxicology, Hazard Evaluation and Risk Assessment

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