The Effects of Six Weeks High Intensity Interval Training on Amyloid Beta1-42 Peptide in Hippocampus of Rat Model of Alzheimer's Disease Induced with STZ

Naderi, Shokufeh; Habibi, Abdolhamid; Kesmati, Mahnaz; Rezaie, Annahita; Ghanbarzadeh, Mohsen

doi:10.5812/jcrps.86866

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…AD is a neurodegenerative condition marked by cognitive decline brought on by protein buildup and excessive phosphorylation in the brain. (27)(28)(29). Similar pathological alterations were found when rats were given an i.p.…”

Section: Discussionsupporting

confidence: 66%

Investigation of the neuroprotective effect of Butein against scopolamine-induced Alzheimer’s like symptoms in rats

2022

pnr

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Objectives: Neuroprotective effect of Butein towards Scopolamine (SCO) induced Alzheimer's disease (AD), experimental rat models. Oral dosage of SCO increases the deposition of Aβ and cognitive dysfunctions. Butein is an abundantly phytochemical constituent of Dalbergia odorifera, Caragana jubata, and Rhus verniciflua stokes has numerous biological activities such as neuroprotective, antioxidant, and antiinflammatory properties.Materials and methods: To conduct the study, the Wistar rat received Scopolamine (1 mg/kg) through the oral route on an alternative day for 14 days. Rats were treated at 3 different doses of Butein (25, 50, and 100 mg/kg, orally) and donepezil (5 mg/kg, orally) for fourteen days. Every week, the behavioural impairments were assessed. Afterwards, rats were sacrificed for biochemical analysis (MDA, Nitrite, and GSH).Results: Our result indicated that Butein reduced SCO, causing cognitive impairment and biochemical and neurobehavioral changes. Butein enhanced neuroprotective impact on cognitive impairment may be owing to its antioxidant and anti-inflammatory, according to the findings.Conclusion: Together these findings suggest that Butein's antioxidant and anti-inflammatory properties may have contributed to its neuroprotective effect, making it a promising therapeutic candidate for the treatment of cognitive impairment and AD-like symptoms.

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Section: Discussionsupporting

confidence: 66%

Investigation of the neuroprotective effect of Butein against scopolamine-induced Alzheimer’s like symptoms in rats

2022

pnr

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Auranofin-loaded PLGA nanoparticles alleviate cognitive deficit induced by streptozotocin in rats model: modulation of oxidative stress, neuroinflammatory markers, and neurotransmitters

Kushawaha,

Ashawat,

Baldi

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Concurrent high-intensity interval training and probiotic supplementation improve associative memory via increase in insulin sensitivity in ovariectomized rats

Bayat¹,

Damirchi²,

Hasannejad‐Bibalan³

et al. 2023

BMC Complement Med Ther

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Objectives Metabolic syndrome (MetS) is a serious concern among postmenopausal women which predisposes them to cardiovascular and cognitive disorders. Healthful diet and exercise training have been essential strategies to prevent the progress of MetS. The aim of this study was to evaluate the effect of supplementation with a native potential probiotic and high-intensity interval training (HIIT) for 8 weeks on retention of associative memory in rats with ovariectomy- induced metabolic syndrome. Method Thirty-two female ovariectomized Wistar rats were divided into four groups (n = 8/group): Control (OVX + Veh), exercise (OVX + Exe), probiotic (OVX + Pro), exercise with probiotic (OVX + Exe + Pro). One sham surgery group was included as a control group. Animals received 8 weeks interventions, and then were tested in a step through passive avoidance learning and memory paradigm, to assess long term memory. Then serum levels of adiponectin, insulin and glucose were measured by ELISA and colorimetry respectively. Data were analyzed by Kruskal-Wallis, Mann-Whitney and also One-way analysis of variance (ANOVA). Results Eight weeks of HIIT and probiotic supplementation caused an increase in step through latency and shortening of total time spent in the dark compartment in OVX + Exe + Pro group compared with OVX + Veh group. Also significant increase in serum adiponectin levels, in parallel with a reduction in glucose, insulin and HOMA-IR were achieved by the group of OVX + Exe + Pro. Conclusion The present study indicates that HIIT combined with probiotics supplementation for 8 weeks effectively improves associative memory in MetS model of rats partly via improving insulin sensitivity and adiponectin level.

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The Effects of Six Weeks High Intensity Interval Training on Amyloid Beta1-42 Peptide in Hippocampus of Rat Model of Alzheimer's Disease Induced with STZ

Cited by 3 publications

References 27 publications

Investigation of the neuroprotective effect of Butein against scopolamine-induced Alzheimer’s like symptoms in rats

Investigation of the neuroprotective effect of Butein against scopolamine-induced Alzheimer’s like symptoms in rats

Auranofin-loaded PLGA nanoparticles alleviate cognitive deficit induced by streptozotocin in rats model: modulation of oxidative stress, neuroinflammatory markers, and neurotransmitters

Concurrent high-intensity interval training and probiotic supplementation improve associative memory via increase in insulin sensitivity in ovariectomized rats

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