The effects of smoking on neutrophil/lymphocyte, platelet/
/lymphocyte ratios

Gümüş, Funda; Solak, İ̇brahim; Eryılmaz, Mehmet

doi:10.4149/bll_2018_023

Cited by 40 publications

(53 citation statements)

References 23 publications

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“…Tobacco exposure could affect white blood cell composition, and the difference in associations between the overall population, low‐risk and never smokers can be explained by the relationship between smoking and white blood cell composition. Indeed, previous studies reported that NLR was significantly higher in smokers than non‐smokers . Similarly, in our study, the proportion of current smokers increased as NLR value increased, but the proportion of current smokers decreased in both men and women as PLR value increased (Tables S1–S3, Supporting information).…”

Section: Discussionsupporting

confidence: 84%

“…Indeed, previous studies reported that NLR was significantly higher in smokers than non-smokers. 12,13 Similarly, in our study, the proportion of current smokers increased as NLR value increased, but the proportion of current smokers decreased in both men and women as PLR value increased (-Tables S1-S3, Supporting information). However, a significant association between the highest NLR quintile and the risk of lung cancer mortality was still observed in both the low-risk group and in never smokers.…”

Section: Discussionsupporting

confidence: 72%

“…However, few studies have evaluated the association between NLR or PLR and lung cancer development in the general population or low‐risk individuals. Tobacco exposure could affect white blood cell composition; compared to non‐smokers, NLR was found to be significantly higher in smokers, whereas PLR level was lower in smokers . Since smoking is the most important risk factor for lung cancer, it is critical to distinguish the impact of NLR and PLR on lung cancer mortality from that of the immune cell changes that follow smoking habits.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort study

Kang

Chang

Ahn

et al. 2019

Intl Journal of Cancer

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Neutrophil‐to‐lymphocyte ratio (NLR) is associated with poor prognosis in patients with lung cancer, but the predictive role of NLR on the risk of developing lung cancer is unknown. We investigated the association between NLR and lung cancer mortality in lung cancer‐free adults. A cohort study was performed with 527,124 Korean adults who were free of lung cancer and were followed for up to 16 years. Vital status and lung cancer‐related deaths were ascertained through national death records. Hazard ratios (HRs) and 95% confidence intervals (CIs) for lung cancer mortality were estimated using a Cox proportional hazards model. During 4,567,495.8 person‐years of follow‐up, 574 lung cancer deaths were identified. A higher NLR was positively associated with lung cancer mortality. The multivariable‐adjusted HR (95% CI) for lung cancer mortality comparing quintiles 2, 3, 4 and 5 of NLR to the lowest quintile were 1.26 (0.96–1.67), 1.23 (0.93–1.63), 1.33 (1.01–1.75) and 1.47 (1.13–1.92), respectively. The highest risk of lung cancer mortality was also observed in the highest NLR quintile among never‐smokers and low‐risk individuals after adjusting for lung function and other possible confounders. Platelet‐to‐lymphocyte ratio showed an inverse J‐shaped association with lung cancer mortality in men but the trends in women, low‐risk individuals or never‐smokers were neither linear nor U‐shaped. In this large cohort of young and middle‐aged individuals, NLR was independently associated with increased risk of lung cancer mortality in low‐risk individuals, indicating a role of systemic inflammation in lung cancer mortality in our study population.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort study

Kang

Chang

Ahn

et al. 2019

Intl Journal of Cancer

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“…Acute ischemic stroke (AIS) is a type of brain injury that develops as a result of thrombotic or embolic occlusion of the brain's blood flow and is affected by inflammatory processes (4). Complete blood count (CBC) parameters and the proportional values obtained from these parameters were reported to have diagnostic values as biomarkers (5)(6)(7)(8). From the perspective of an ED physician, tests such as a CBC are simply components of routine practice and often have no direct impact on ED applications or diagnostic/prognostic value (9).…”

Section: Introductionmentioning

confidence: 99%

Importance of complete blood count parameters and neutrophil-to-lymphocyte ratio in central and peripheral vertigo

Bilge¹

2020

GMJ

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“…Previous studies using various biomarkers have shown that smoking increases systemic inflammation (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Effects of Smoking on Volume, Conductivity and Scatter Parameters of Leukocytes

et al. 2020

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Aim: In this study, we aimed to determine changes in leukocytes volume, conductivity and scatter parameters in smokers compared to non-smokers. Methods: A total of 117 individuals (45 smokers and 72 non-smokers) were included in the study. While those who smoked at least 10 pack-years were included in the case group, those who never smoked at all were included in the control group. Results: While there was a statistically significant difference in mean neutrophil volume, mean neutrophil conductivity, mean lymphocyte conductivity, mean lymphocyte scatter, mean monocyte volume, mean monocyte conductivity, mean monocyte scatter, mean eosinophil conductivity values between the two groups, there was no statistically significant difference in mean neutrophil scatter, mean lymphocyte volume, mean eosinophil volume, mean eosinophil scatter values between the two groups. Conclusion: This study showed that smoking affected volume, conductivity and scatter parameters. Clinicians should consider whether the patient smokes if they want to diagnose any diseases using volume, conductivity and scatter parameters. Keywords: smoking, leukocytes, conductivity, scattering, neutrophils

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The effects of smoking on neutrophil/lymphocyte, platelet/ /lymphocyte ratios

Abstract: As a result of our study, an increase in the NLR which is used as a systemic inflammatory marker, a decrease in the PLR and an increase in the MPV/Plt ratio which indicates thromboembolism risk were found for the smoker group (Tab. 3, Ref. 32).

Cited by 40 publications

References 23 publications

Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort study

Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort study

Importance of complete blood count parameters and neutrophil-to-lymphocyte ratio in central and peripheral vertigo

Effects of Smoking on Volume, Conductivity and Scatter Parameters of Leukocytes

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