The effects of social defeat on behavior and dopaminergic markers in mice

Jin, Hongmei; Muna, Sushma Shrestha; Bagalkot, Tarique Rajasaheb; Cui, Yin; Yadav, Binod Kumar; Chung, Young‐Chul

doi:10.1016/j.neuroscience.2014.12.043

Cited by 55 publications

(46 citation statements)

References 51 publications

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“…When testing the mice on D30, no deficit in the short-term memory of CSDS-subjected animals was observed in ITI1 conditions, but the memory performances of stressed-HEC mice were significantly altered in the ITI24 ones. These data corroborated previous studies that also described impaired cognition in social-defeated mice using the NOR test1641 with mnesic alterations in that case recorded at both short and long term, but measured 5 days only after the last defeat session. Interestingly, we showed that long term memory was still affected 3 weeks after CSDS.…”

Section: Discussionsupporting

confidence: 91%

“…Those results did not meet previous results since agomelatine after chronic administration at the same dose ranges has been shown to display significant efficacy in various preclinical depression-like models related to stress including the transgenic GR-i mouse3637, the corticosterone-treated mouse38, the chronic mild stress in rats39 and the prenatally stressed rat2940, but for most of them, the stress procedure was different and based on much milder stressors than those applied here. As expected from CSDS experiments, susceptible mice displayed a strong decreased in the exploration of the center of an open field on D11, indicating a clear-cut anxious-like phenotype4142. On D29, the effect of social defeat stress on anxiety-related behavior was still present in stressed-HEC mice, but again, agomelatine was not able to reverse this behavior.…”

Section: Discussionsupporting

confidence: 55%

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Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice

Martin¹,

Allaïli²,

Euvrard³

et al. 2017

Sci Rep

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Chronic stress is known to induce not only anxiety and depressive-like phenotypes in mice but also cognitive impairments, for which the action of classical antidepressant compounds remains unsatisfactory. In this context, we investigated the effects of chronic social defeat stress (CSDS) on anxiety-, social- and cognitive-related behaviors, as well as hippocampal Bdnf, synaptic plasticity markers (PSD-95, Synaptophysin, Spinophilin, Synapsin I and MAP-2), and epigenetic modifying enzymes (MYST2, HDAC2, HDAC6, MLL3, KDM5B, DNMT3B, GADD45B) gene expression in C57BL/6J mice. CSDS for 10 days provoked long-lasting anxious-like phenotype in the open field and episodic memory deficits in the novel object recognition test. While total Bdnf mRNA level was unchanged, Bdnf exon IV, MAP-2, HDAC2, HDAC6 and MLL3 gene expression was significantly decreased in the CSDS mouse hippocampus. In CSDS mice treated 3 weeks with 50 mg/kg/d agomelatine, an antidepressant with melatonergic receptor agonist and 5-HT2C receptor antagonist properties, the anxious-like phenotype was not reversed, but the treatment successfully prevented the cognitive impairments and hippocampal gene expression modifications. Altogether, these data evidenced that, in mice, agomelatine was effective in alleviating stress-induced altered cognitive functions, possibly through a mechanism involving BDNF signaling, synaptic plasticity and epigenetic remodeling.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 55%

Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice

Martin¹,

Allaïli²,

Euvrard³

et al. 2017

Sci Rep

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“…Social defeat bears anxiogenic consequences, as assessed by unconditioned anxiety tests [13,14]. The previous studies from our and other laboratories showed that C57BL/6J mice subjected to a 6-or 10-day period of SD stress induced by repeated CD-1 mouse aggression displayed significant social interaction avoidance behaviors representing symptoms of anxiety [15][16][17]. In the present study, by combining SD stress with complete Freund's adjuvant (CFA)-induced chronic inflammatory pain models, we further investigated the reciprocal relationship between pain and anxiety-like behaviors.…”

Section: Introductionmentioning

confidence: 92%

Persistent, comorbid pain and anxiety can be uncoupled in a mouse model

Liu

Yang

et al. 2015

Physiology & Behavior

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“…Experimental studies that address the long-term effects of social stress, due to ethical and time constraints, often require the use of animal models (Tanaś et al 2015). Social defeat stress in animals, defined as being defeated in confrontations with conspecific animals (Jin et al 2015), is frequently induced by the resident/intruder paradigm (Björkqvist 2001). This kind of stress has been reported to cause a variety of behavioral, neuroendocrinological, physiological, neurochemical, neurological and immunological changes (Blanchard et al 2001, Buwalda et al 2005, Niebylski et al 2012) that resemble certain symptoms of human psychopathologies, such as depression and anxiety (Bartolomucci and Leopardi 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of social stress and clomipramine on emotional memory in mice

Duque¹,

Vinader‐Caerols²,

Monleón³

2016

Acta Neurobiologiae Experimentalis

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We have previously observed impairing effects of social defeat stress (CSDS) on inhibitory avoidance (IA) in mice. Given the similarity between changes produced by social stress in animals and symptoms of certain human psychopathologies such as depression and anxiety, the effects of the antidepressant clomipramine on IA impairment produced by CSDS were evaluated in the present study.Male CD1 mice were randomly assigned to the groups: non-stressed+saline, non-stressed+clomipramine, stressed+saline and stressed+clomipramine. Stressed animals were subjected to daily agonistic encounters (10 min) in the home cage of the aggressor over a 20-day period. Just before each encounter, non-stressed and stressed mice were injected i.p. with saline or clomipramine (10 mg/kg) according to their experimental condition. 24 hours after the last CSDS session, all the mice were tested in a step-through IA task. In the IA training phase, animals were punished by a shock to the paw when they entered the dark compartment of the apparatus. In the IA test phase (one week later) the same procedure took place, but without shock. Complementary measures were obtained by evaluating all the animals in an elevated plus maze (locomotor activity and emotionality) and on a hot plate (analgesia). IA learning was confirmed in all groups except the stressed+saline group, which was the only one that exhibited higher anxiety levels. No variations were observed in either locomotor activity or analgesia. In conclusion, CSDS induces anxiety and impairs emotional memory in mice; the negative effects of CSDS on memory appear to be attenuated by clomipramine, and these detrimental effects do not seem to be secondary to the effects of CSDS on locomotor activity, emotionality or pain sensitivity.

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The effects of social defeat on behavior and dopaminergic markers in mice

Cited by 55 publications

References 51 publications

Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice

Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice

Persistent, comorbid pain and anxiety can be uncoupled in a mouse model

Effects of social stress and clomipramine on emotional memory in mice

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