The effects of stenosis severity on the hemodynamic parameters—assessment of the correlation between stress phase angle and wall shear stress

Sadeghi, Mahmood; Shirani, Ebrahim; Tafazzoli-Shadpour, Mohammad; Samaee, Milad

doi:10.1016/j.jbiomech.2011.08.017

Cited by 36 publications

(41 citation statements)

References 51 publications

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“…2. The equation for the artery in stenotic region is as follows [18]: Table 1 shows the characteristics of blood and arterial wall [18]. The average velocity profile applied to the inlet of the fluid region for a right coronary artery has been provided by Zeng et al [19].…”

Section: Methodsmentioning

confidence: 99%

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Numerical simulation of hemodynamic parameters of turbulent and pulsatile blood flow in flexible artery with single and double stenoses

2015

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This article investigates the pulsatile and turbulent blood flows in flexible artery with single and double stenoses. The changes in pressure drop, mean wall shear stress (WSS), radial displacement of the artery, and oscillating shear index are investigated. Similar to experimental data, the results of the present study show that a laminar flow occurs for stenosis of up to 70%, and for 80% stenosis the flow is turbulent. The mean WSS analysis shows that assuming the flow is laminar causes more errors than assuming the walls are solid. The comparison of the results for single stenosis with those for double stenosis reveals that the dilation in the arterial walls in double stenoses is much more common than in single stenosis. Therefore, the maximum mean WSS in double stenoses is less than that in single stenosis. The results also indicate that the axial pressure drop in double stenoses is higher than that in single stenosis.

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Section: Methodsmentioning

confidence: 99%

“…Fluid-structure interaction (FSI) boundary condition was used for fluid and solid boundaries. The governing equations for solid-fluid coupling problems are displacement, stress, and non-slip conditions [18]. The governing equation for the solid domain can be written as [18]: …”

Section: Methodsmentioning

confidence: 99%

Numerical simulation of hemodynamic parameters of turbulent and pulsatile blood flow in flexible artery with single and double stenoses

2015

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“…Tada et al (2007) examined the effect of the SPA on the strain energy density of the EC plasma membrane showing that mean satrain energy density was increased for out-of-phase SPA. Other recent studies have suggested the SPA as a factor in plaque development in the right coronary artery (Torii et al 2009), the carotid artery (Makris et al 2010), and arterial stenoses (Sadeghi et al 2011). …”

Section: Arterial Fluid Mechanics and Vascular Diseasementioning

confidence: 99%

Fluid Mechanics, Arterial Disease, and Gene Expression

Tarbell

Shi

Dunn

et al. 2014

Annu. Rev. Fluid Mech.

135

121

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This review places modern research developments in vascular mechanobiology in the context of hemodynamic phenomena in the cardiovascular system and the discrete localization of vascular disease. The modern origins of this field are traced, beginning in the 1960s when associations between flow characteristics, particularly blood flow–induced wall shear stress, and the localization of atherosclerotic plaques were uncovered, and continuing to fluid shear stress effects on the vascular lining endothelial) cells (ECs), including their effects on EC morphology, biochemical production, and gene expression. The earliest single-gene studies and genome-wide analyses are considered. The final section moves from the ECs lining the vessel wall to the smooth muscle cells and fibroblasts within the wall that are fluid me chanically activated by interstitial flow that imposes shear stresses on their surfaces comparable with those of flowing blood on EC surfaces. Interstitial flow stimulates biochemical production and gene expression, much like blood flow on ECs.

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“…In contrast, high shear stress develops upstream in the pre-stenotic regions, where the “shoulder” of the plaque is susceptible to fluid and mechanical mismatch or Von Mises stress to destabilize the plaque for rupture [10]. Thus, hemodynamic shear stress is low in post-stenotic but high in pre-stenotic regions [11]. The combination of OSS and low mean shear stress favors atherogenesis, whereas pulsatile and high shear stress confers protection [12].…”

Section: Spatial Variations In Hemodynamic Shear Stressmentioning

confidence: 99%

Blood flow modulation of vascular dynamics

Lee¹,

Packard

Hsiai

2015

Current Opinion in Lipidology

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Purpose of review Blood flow is intimately linked with cardiovascular development, repair, and dysfunction. The current review will build on the fluid mechanical principle underlying hemodynamic shear forces, mechanotransduction, and metabolic effects. Recent findings Pulsatile flow produces both time- (∂τ /∂t)and spatial-varying shear stress (∂τ /∂x) to modulate vascular oxidative stress and inflammatory response with pathophysiological significance to atherosclerosis. The characteristics of hemodynamic shear forces; namely, steady laminar (∂τ /∂t= 0), pulsatile (PSS: unidirectional forward flow), and oscillatory shear stress (OSS: bidirectional with a near net 0 forward flow) modulate mechano-signal transduction to influence metabolic effects on vascular endothelial function. Atheroprotective PSS promotes anti-oxidant, anti-inflammatory, and anti-thrombotic responses, whereas atherogenic OSS induces NADPH oxidase–JNK signaling to increase mitochondrial superoxide production, protein degradation of manganese superoxide dismutase (MnSOD), and post-translational protein modifications of LDL particles in the disturbed flow-exposed regions of vasculature. In the era of tissue regeneration, shear stress has been implicated in re-activation of developmental genes; namely, Wnt and Notch signaling, for vascular development and repair. Summary Blood flow imparts a dynamic continuum from vascular development to repair. Augmentation of PSS confers atheroprotection and re-activation of developmental signaling pathways for regeneration.

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The effects of stenosis severity on the hemodynamic parameters—assessment of the correlation between stress phase angle and wall shear stress

Cited by 36 publications

References 51 publications

Numerical simulation of hemodynamic parameters of turbulent and pulsatile blood flow in flexible artery with single and double stenoses

Numerical simulation of hemodynamic parameters of turbulent and pulsatile blood flow in flexible artery with single and double stenoses

Fluid Mechanics, Arterial Disease, and Gene Expression

Blood flow modulation of vascular dynamics

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