The effects of stress on alcohol consumption: mild acute and sub-chronic stressors differentially affect apomorphine susceptible and unsusceptible rats

Kam, Elizabeth L. van der; Coolen, J.; Ellenbroek, Bart A.; Cools, Alexander R.

doi:10.1016/j.lfs.2004.10.030

Cited by 10 publications

(1 citation statement)

References 32 publications

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“…In this context, an extensive body of research has linked both physical and psychosocial stressors to alcohol consumption in humans and experimental animals (Pohorecky, 1981, 1990, 1991; Sillaber and Henniger, 2004). This research area is rather complex, however, as stress has been reported to either increase or decrease voluntary ethanol intake, depending on numerous situational and organismal factors, including the type of stressor, the history of both stress and alcohol exposure, genetic background, sex, and ethanol preference phenotype (Bond, 1978; Chester et al., 2004, 2006; van der Kam et al., 2005; Lynch et al., 1999; Rockman and Glavin, 1986; Rockman et al., 1986; Vengeliene et al., 2003; Volpicelli et al., 1990).…”

mentioning

confidence: 99%

Repeated Light–Dark Phase Shifts Modulate Voluntary Ethanol Intake in Male and Female High Alcohol‐Drinking (HAD1) Rats

Clark

Fixaris

Belanger

et al. 2007

Alcoholism Clin & Exp Res

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Background: Chronic disruption of sleep and other circadian biological rhythms, such as occurs in shift work or in frequent transmeridian travel, appears to represent a significant source of allostatic load, leading to the emergence of stress-related physical and psychological illness. Recent animal experiments have shown that these negative health effects may be effectively modeled by exposure to repeated phase shifts of the daily light-dark (LD) cycle. As chronobiological disturbances are thought to promote relapse in abstinent alcoholics, and may also be associated with increased risk of subsequent alcohol abuse in nonalcoholic populations, the present experiment was designed to examine the effects of repeated LD phase shifts on voluntary ethanol intake in rats. A selectively bred, high alcohol-drinking (HAD1) rat line was utilized to increase the likelihood of excessive alcoholic-like drinking.Methods: Male and female rats of the selectively bred HAD1 rat line were maintained individually under a LD 12:12 cycle with both ethanol (10% v ⁄ v) and water available continuously. Animals in the experimental group were subjected to repeated 6-hour LD phase advances at 3 to 4 week intervals, while control rats were maintained under a stable LD cycle throughout the study. Contact-sensing drinkometers were used to monitor circadian lick patterns, and ethanol and water intakes were recorded weekly.Results: Control males showed progressively increasing ethanol intake and ethanol preference over the course of the study, but males exposed to chronic LD phase shifts exhibited gradual decreases in ethanol drinking. In contrast, control females displayed decreasing ethanol intake and ethanol preference over the course of the experiment, while females exposed to experimental LD phase shifts exhibited a slight increase in ethanol drinking.Conclusions: Chronic circadian desynchrony induced by repeated LD phase shifts resulted in sex-specific modulation of voluntary ethanol intake, reducing ethanol intake in males while slightly increasing intake in females. While partially contrary to initial predictions, these results are consistent with extensive prior research showing that chronic stress may either increase or decrease ethanol intake, depending on strain, sex, stressor type, and experimental history. Thus, repeated LD phase shifts may provide a novel chronobiological model for the analysis of stress effects on alcohol intake.

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confidence: 99%

Repeated Light–Dark Phase Shifts Modulate Voluntary Ethanol Intake in Male and Female High Alcohol‐Drinking (HAD1) Rats

Clark

Fixaris

Belanger

et al. 2007

Alcoholism Clin & Exp Res

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The Effects of Non-selective Dopamine Receptor Activation by Apomorphine in the Mouse Hippocampus

et al. 2018

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Apomorphine is a dopamine receptor agonist that activates D-D dopamine receptors and that is used to treat Parkinson's disease (PD). However, the effect of apomorphine on non-motor activity has been poorly studied, and likewise, the effects of dopaminergic activation in brain areas that do not fulfill motor functions are unclear. The aim of this study was to determine how dopamine receptor activation affects behavior, as well as plasticity, morphology, and oxidative stress in the hippocampus. Adult mice were chronically administered apomorphine (1 mg/kg for 15 days), and the effects on memory and learning, synaptic plasticity, dendritic length, inflammatory responses, and oxidative stress were evaluated. Apomorphine impaired learning and long-term memory in mice, as evaluated in the Morris water maze test. In addition, electrophysiological recording of field excitatory postsynaptic potentials (fEPSP) indicated that the long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus was fully impaired by apomorphine. In addition, a Sholl analysis of Golgi-Cox stained neurons showed that apomorphine reduced the total length of dendrites in the CA1 region of the hippocampus. Finally, there were more reactive astrocytes and oxidative stress biomarkers in mice administered apomorphine, as measured by GFAP immunohistochemistry and markers of redox balance, respectively. Hence, the non-selective activation of dopaminergic receptors in the hippocampus by apomorphine triggers deficiencies in learning and memory, it prevents LTP, reduces dendritic length, and provokes neuronal damage.

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Drug Addiction

Ellenbroek

2016

Gene-Environment Interactions in Psychiatry

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The effects of stress on alcohol consumption: mild acute and sub-chronic stressors differentially affect apomorphine susceptible and unsusceptible rats

Cited by 10 publications

References 32 publications

Repeated Light–Dark Phase Shifts Modulate Voluntary Ethanol Intake in Male and Female High Alcohol‐Drinking (HAD1) Rats

Repeated Light–Dark Phase Shifts Modulate Voluntary Ethanol Intake in Male and Female High Alcohol‐Drinking (HAD1) Rats

The Effects of Non-selective Dopamine Receptor Activation by Apomorphine in the Mouse Hippocampus

Drug Addiction

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