The effects of structurally defined triglycerides of differing fatty acid composition on postprandial haemostasis in young, healthy men

Hunter, Kirsty; Crosbie, Lynn; Weir, A. J.; Miller, George; Duttaroy, Asim K.

doi:10.1016/s0021-9150(98)00231-7

Cited by 20 publications

(8 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to the present study, ingestion of fat did not result in elevated levels of PF1.2 in earlier studies [7,19], which may be the result of the long plasma half life of PF1.2 obscuring acute effects of coagulation activation. Hunter et al [20] found only a minor increase in FpA after test meals in healthy male volunteers, but compared with the present study, the test meals contained a considerably less fat.…”

Section: Discussioncontrasting

confidence: 90%

Activation of coagulation during alimentary lipemia under real-life conditions

Elmas

Kälsch

Suvajac

et al. 2007

International Journal of Cardiology

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 90%

Activation of coagulation during alimentary lipemia under real-life conditions

Elmas

Kälsch

Suvajac

et al. 2007

International Journal of Cardiology

View full text Add to dashboard Cite

“…Results from recent human (10)(11)(12)(13)(14) and animal (15)(16)(17)(18) studies show that differences between the fatty acid acyl position distribution in native and randomized dietary fats do not influence lipoprotein and serum cholesterol concentrations. A few studies have used specific dietary TAG structures, such as 1,3-dioleoyl-2-palmitoylglycerol, 1-palmitoyl-2,3-dioleoylglycerol, 1,3-dioleoyl-2-stearoylglycerol, and 1-stearoyl-2,3-dioleoylglycerol, to compare the influence of the sn-1,3 and sn-2 positions on fatty acid metabolism (3,19,20). The authors of these studies concluded that the sn-1,3 and sn-2 locations of FA on the glycerin backbone did not affect their metabolism.…”

mentioning

confidence: 99%

Effect of triacylglycerol structure on absorption and metabolism of isotope‐labeled palmitic and linoleic acids by humans

Emken

Adlof

Duval

et al. 2004

Lipids

View full text Add to dashboard Cite

The effect of dietary TAG structure and fatty acid acyl TAG position on palmitic and linoleic acid metabolism was investigated in four middle-aged male subjects. The study design consisted of feeding diets containing 61 g/d of native lard (NL) or randomized lard (RL) for 28 d. Subjects then received an oral dose of either 1,3-tetradeuteriopalmitoyl-2-dideuteriolinoleoyl-rac-glycerol or a mixture of 1,3-dideuteriolinoleoyl-2-tetradeuteriopalmitoyl-rac-glycerol and 1,3-hexadeuteriopalmitoyl-2-tetradeuteriolinoleoyl-rac-glycerol. Methyl esters of plasma lipids isolated from blood samples drawn over a 2-d period were analyzed by GC-MS. Results showed that absorption of the 2H-fatty acids (2H-FA) was not influenced by TAG position. The 2H-FA at the 2-acyl TAG position were 85+/-4.6% retained after absorption. Substantial migration of 2H-16:0 (31.2+/-8.6%) from the sn-2 TAG position to the sn-1,3 position and 2H-18:2n-6 (52.8+/-6.4%) from the sn-1,3 position to the sn-2 position of chylomicron TAG occurred after initial absorption and indicates the presence of a previously unrecognized isomerization mechanism. Incorporation and turnover of the 2H-FA in chylomicron TAG, plasma TAG, and plasma cholesterol esters were not influenced by TAG acyl position. Accretion of 2H-16:0 from the sn-2 TAG position in 1-acylphosphatidylcholine was 1.7 times higher than 2H-16:0 from the sn-1,3 TAG positions. Acyl TAG position did not influence 2H-18:2n-6 incorporation in PC. The concentration of 2H-18:2n-6-derived 2H-20:4n-6 in plasma PC from subjects fed the RL diet was 1.5 times higher than for subjects fed the NL diet, and this result suggests that diets containing 16:0 located at the sn-2 TAG position may inhibit 20:4n-6 synthesis. The overall conclusion is that selective rearrangement of chylomicron TAG structures diminishes but does not totally eliminate the metabolic and physiological effects of dietary TAG structure.

show abstract

“…The SN‐1(3) and SN‐2 positions of SSS were stearic acid (SA) molecules, and the SN‐1(3) and SN‐2 positions of OOO were OA molecules and LA molecules were on the SN‐1(3) and SN‐2 positions of LLL. Different FA of these SGs in diet might induce potentially detrimental or beneficial changes in cardiovascular diseases (Hunter and others ). Under the action of triglyceride in a series of lipase, decompose generate glycerol and fatty acids and free fatty acids were released into the bloodstream for other groups.…”

Section: Resultsmentioning

confidence: 99%

Effects of Different Simple Triglycerides on Cell Fatty Acid Compositions, Proliferation‐Related Protein, and Gene Expressions Induced by Oxidized‐LDL in HUVSMCs

Pan

Luo

et al. 2017

Journal of Food Science

View full text Add to dashboard Cite

The proliferating effects of 3 different simple triglycerides (tristearin, triolein, and trilinolein) on the human umbilical vein smooth muscle cells (HUVSMCs) induced by oxidized-LDL (ox-LDL) were investigated in this study. The protein and mRNA gene expressions of proliferating cell nuclear antigen (PCNA), smooth muscle-α-actin (SM-α-actin), and monocyte chemoattractant protein-1 (MCP-1) in HUVSMCs were measured by Western blotting and real-time quantitative polymerase chain reaction (PCR). It was shown that in tristearin (SSS) treated HUVSMCs, the saturated fatty acid content was increased, and the compositions of polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid were decreased significantly. On the other hand, triolein (OOO) and trilinolein (LLL) significantly increased the levels of some typical PUFA such as arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. Moreover, LLL and OOO could upregulate the protein and mRNA expressions of PCNA, MCP-1 as well as downregulate the expression of SM-α-actin. The results also showed that, SSS had significant promotion effects on the proliferation of HUVSMCs induced by ox-LDL. Although both LLL and OOO could inhibit the proliferation of HUVSMCs induced by ox-LDL, and might have certain inhibition of the atherosclerotic process.

show abstract

The effects of structurally defined triglycerides of differing fatty acid composition on postprandial haemostasis in young, healthy men

Cited by 20 publications

References 38 publications

Activation of coagulation during alimentary lipemia under real-life conditions

Activation of coagulation during alimentary lipemia under real-life conditions

Effect of triacylglycerol structure on absorption and metabolism of isotope‐labeled palmitic and linoleic acids by humans

Effects of Different Simple Triglycerides on Cell Fatty Acid Compositions, Proliferation‐Related Protein, and Gene Expressions Induced by Oxidized‐LDL in HUVSMCs

Contact Info

Product

Resources

About