The effects of tamoxifen and soy on dark neuron production in hippocampal formation after pentylenetetrazole-induced repeated seizures in rats

Ebrahimzadeh‐Bideskan, Alireza; Ataei, Maryam Lale; Mansouri, Somaieh; Hosseini, Mahmoud

doi:10.1016/j.pathophys.2015.04.001

Cited by 11 publications

(4 citation statements)

References 88 publications

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“…The slides were counterstained with hematoxylin and mounted. An unbiased stereological method was used for counting NeuN+ neurons, as previously described [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury

Sakhaie

Soleimani

Pourheydar

et al. 2017

Behavioural Neurology

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Exposure to extremely low-frequency electromagnetic fields may induce constant modulation in neuronal plasticity. In recent years, tremendous efforts have been made to design a suitable strategy for enhancing adult neurogenesis, which seems to be deterred due to brain senescence and several neurodegenerative diseases. In this study, we evaluated the effects of ELF-EMF on neurogenesis and memory, following treatment with trimethyltin chloride (TMT) as a neurotoxicant. The mice in all groups (n = 56) were injected with BrdU during the experiment for seven consecutive days to label newborn cells. Spatial memory was assessed by the Morris water maze (MWM) test. By the end of the experiment, neurogenesis and neuronal differentiation were assessed in the hippocampus, using immunohistochemistry and Western blot analysis. Based on the findings, exposure to ELF-EMF enhanced spatial learning and memory in the MWM test. ELF-EMF exposure significantly enhanced the number of BrdU+ and NeuN+ cells in the dentate gyrus of adult mice (P < 0.001 and P < 0.05, resp.). Western blot analysis revealed significant upregulation of NeuroD2 in ELF-EMF-exposed mice compared to the TMT-treated group (P < 0.05). These findings suggest that ELF-EMF might have clinical implications for the improvement of neurodegenerative processes and could help develop a novel therapeutic approach in regenerative medicine.

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“…The slides were counterstained with hematoxylin and mounted. An unbiased stereological method was used for counting NeuN+ neurons, as previously described [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury

Sakhaie

Soleimani

Pourheydar

et al. 2017

Behavioural Neurology

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“…It has also been evidenced that recurrent and even a single convulsive seizure induced by such as pentylenetetrazole (gamma-aminobutyric acid inhibitor) lead to neuronal damage and cell death in form of appearance of dark neurons in different areas of the brain including the pyramidal layer of cortex, reticular formation, hippocampus and limbic system (Bideskan et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant Activity of Hydroalcoholic Phoenix dactylifera Fruit Extract and Pimpinella anisum Oil in Mice

El‐Nabtity¹,

Shaban²,

Moselhi³

et al. 2019

American Journal of Animal and Veterinary Sciences

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Epilepsy is a group of long-term neurological disorders characterized by epileptic seizures. The present study sought to investigate the anticonvulsant and neuroprotective Activity of Hydroalcoholic Phoenix dactylifera fruit extract (HAPD) and Pimpinella Anisum Oil (PAO) against Pentylenetetrazole (PTZ) and Maximal Electric Shock (MES) induced a seizure in mice. Mice groups were treated with HAPD1000 mg/kg, PAO 4 ml/kg. The onset of a seizure and generalized seizure were measured, followed by Gamma-Aminobutyric Acid (GABA) and antioxidant enzymes assessments. The potential of these substances to induce any neurological toxicity was also evaluated by using rotarod, forced swim test and horizontal screen test. The current study demonstrates that HAPD and PAO delay onset of the seizure and generalized seizure, also elevated GABA and antioxidant enzymes level and haven't any neurological toxicity. The current study suggests that hydroalcoholic Phoenix dactylifera extract and Pimpinella anisum oil have anticonvulsant, neuroprotective and antioxidant activity and can increase brain GABA level.

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“…It has been also shown that even when there is no mechanical trauma the dark neurons will be produced in pathological conditions. Some of these cases are ischemia, hypoglycemia, exposure to excitatory amino acids such as glutamate and also epilepsy …”

Section: Discussionmentioning

confidence: 99%

“…The increase in the glutamate release and cell excitability, followed by an increase in the intracellular calcium levels are other important mechanism of the PTZ in the pathology of epilepsy and seizures that lead to cell death and increased production of the dark neurons . In recent studies, it has been shown that apigenin and luteolin, which are natural flavonoids found in many plants—with the reduction of the calcium influx through blocking the calcium channels—cause the control of the glutamate release in the hippocampus of the rats .…”

Section: Discussionmentioning

confidence: 99%

The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

Allahyari

Hosseini

Azizi

2019

Neurology & Clinical Neurosc

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Background The genus Tanacetum is widespread in Europe and Western Asia. It is an important traditional plant which has been used in the treatment of many illnesses. Aim In the present study, the effect of the hydroalcoholic extract of Tanacetum polycephalum (henceforth TP) on the animal model of seizure was studied. Methods In this experimental study, 42 male Wistar rats weighing 220‐250 g were randomly selected and were divided to experimental and control groups (six rats per group). The experimental groups were treated by intraperitoneal (ip) single injection of 150, 300, 450, 600, and 750 mg kg−1 of hydroalcoholic extracts of TP. The control negative group received normal saline (0.9%) and the control positive group received phenobarbital (30 mg kg−1, ip) pretreatment. 30 minutes after the treatments, the seizure behaviors were evaluated by pentylenetetrazol (PTZ; 70 mg kg−1, ip) challenge. In addition, after experiment, the rats were put to death and brain was removed for the histological study. Results The ANOVA test was showed that compared to control group, all the TP doses delayed the initiation and duration of the tonic, clonic, and tonic‐clonic seizures and significantly reduced the tonic and clonic seizures (P < 0.001). Furthermore, the administration of all five doses of the extract significantly prevented the production of the dark neurons (P < 0.001) in different areas of the hippocampus compared to PTZ group. Conclusions We can conclude that the TP extract has beneficial effects on the prevention of the PTZ‐induced seizure.

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The effects of tamoxifen and soy on dark neuron production in hippocampal formation after pentylenetetrazole-induced repeated seizures in rats

Cited by 11 publications

References 88 publications

Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury

Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury

Anticonvulsant Activity of Hydroalcoholic Phoenix dactylifera Fruit Extract and Pimpinella anisum Oil in Mice

The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

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