The Effects of Tetrandrine on the Contractile Function and Microvascular Permeability in the Stunned Myocardium of Rats.

Chen, Jin‐Ming; Wu, Zonggui; Chen, Sicong; Gong, Xiaoqi; Zhong, Jun; Zhang, Guo-Yuan

doi:10.2170/jjphysiol.49.499

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Sinomenine inhibited I Ca , and at higher concentrations also decreased I K , which may result in APD prolongation. Similarly, tetrandrine markedly inhibited I Ca , but at low concentrations, it had less or no effect on I K , consistent with previous reports (Takemura et al, 1996;Chen et al, 1999). Liu et al (1992) have demonstrated the inhibition of both L-and T-type Ca 2+ channel currents by tetrandrine.…”

Section: Discussionsupporting

confidence: 90%

“…Among the constituents of SCR, tetrandrine has been most examined and reported to possess active cardiac electropharmacological actions (Fang and Jiang, 1986;Huang et al, 1998). Tetrandrine depresses heart rate and contractility, and inhibits the voltage-dependent Ca 2+ channel on cardiac cell membranes (Wang and Lemos, 1995;Liu et al, 1992;Chen et al, 1999). Sinomenine has been found to decrease blood pressure (Xia and Jin, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Electropharmacological Actions of the Constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in Guinea Pig Heart

Satoh

2005

Am. J. Chin. Med.

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Cardiac actions of the constituents of Sinomeni Caulis et Rhizome (SCR) and Mokuboi-to, a traditional herbal drug, were investigated. In voltage-clamp experiments, sinomenine (1 mM) and tetrandrine (100 microM) inhibited the ionic currents concentration-dependently. The constituents affected the action potential configurations. In multicellular preparations, SCR (1 mg/ml) decreased the maximum rate of depolarization. Tetrandrine (30 microM) and sinomenine (300 microM) also had similar effects, but magnoflorine (1 mM) had less or no effect. Dysrhythmias were abolished under Ca(2+) overload conditions by sinomenine. These results indicate that at even acute administrations, these drugs exert the active electropharmacological actions and cardioprotections.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Electropharmacological Actions of the Constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in Guinea Pig Heart

Satoh

2005

Am. J. Chin. Med.

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“…The mechanism by which tetrandrine inhibits rat hepatic stellate cell activation is not clear. As to the possible mechanisms of the effects of tetrandrine on rat hepatic stellate cells, tetrandrine administration has been shown to block the calcium channels in various cell types (Weinberg et al 1994;Liu et al 1995;Chen et al 1999). Recent investigation found that voltage-operated calcium channel (VOCC) plays an important role in the regulation of hepatic stellate cells contractility which is the marked phenotype of activated hepatic stellate cells (Berlin 1995;Bataller et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Effect of Tetrandrine on Experimental Hepatic Fibrosis Induced by Bile Duct Ligation and Scission in Rats

Park

Nan

Park

et al. 2000

Pharmacology & Toxicology

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Tetrandrine, an alkaloid isolated from the Chinese medicinal herb Stephania tetrandra, has been shown to elicit antifibrotic effects in various cell types. In the present study, the effect of tetrandrine on liver fibrosis was investigated by using bile duct ligation and scission in rats as a model of hepatic fibrosis. Treatment with tetrandrine in fibrotic rats reduced serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels to 72%, 52% and 51% that of controls at 10 mg/kg/day, respectively. Liver hydroxyproline contents in tetrandrine-treated rats with bile duct ligation and scission were also reduced to 65% of that of control rats with bile duct ligation and scission at 10 mg/kg/day. The morphological characteristics of fibrotic liver, which appeared in control bile duct ligation and scission group, were improved in tetrandrine-treated bile duct ligation and scission group. We also examined the effect of tetrandrine on cultured rat hepatic stellate cells, which plays an important role in the pathogenesis of hepatic fibrosis, activation to investigate whether it could act mainly by direct action on rat hepatic fibroblastic cells. In cultured rat hepatic stellate cells, tetrandrine reduced DNA synthesis to 57% of control hepatic stellate cells at 10 mg/ml without affecting cell viability. Smooth muscle-a-actin expression, the phenotypic marker of activated hepatic stellate cells, was also decreased. We conclude that tetrandrine has an antifibrotic effect on liver fibrosis in rats induced by bile duct ligation and scission, indicating that it might exert a direct effect on rat hepatic stellate cells.Hepatic fibrosis is a consequence of severe liver damage that occurs in many patients with chronic liver disease. Regardless of many different causes, hepatic fibrosis is characterized by increased and altered deposition of newly formed extracellular matrix components such as collagens, proteoglycans, fibronectin and hyaluronic acid (Friedman 1993), leading to the complication of portal hypertension and hepatic failure.In the injured liver, these extracellular matrix components are produced in hepatic stellate cells in the space of Disse, which function in intact liver lobules as the primary storage area for retinoids (Hendrisks et al. 1985). During the course of ongoing liver fibrogenesis, hepatic stellate cells acquire myofibroblastic features, proliferate (Friedman et al. 1989;Hautekeete & Geerts 1997), synthesize increased amounts of extracellular matrix components (Shiratori et al. 1987) and express smooth muscle-a-actin . The transformation of hepatic stellate cells into myofibroblast-like cells is recognized as a critical step in hepatic fibrosis. Therefore, this cell type is an important target for antifibrotic therapy.Tetrandrine is a bis-benzyl isoquinoline alkaloid derived from Stephania tetrandra (Moore). This compound has been characterized pharmacologically to exhibit hypotensive, immunosuppressive properties (Sutter & Wang 1993), and inhibition of lipid perox...

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“…Tetrandrine administration has been shown to block the calcium channels in various cell types [23] . Moreover, activated hepatic stellate cells have receptors for a number of vasoconstrictor substances such as endotheline, angiotensin Ⅱ, vasopressin, thrombin and thromboxan A2 [24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model

Yin

Lian²,

Piao³

et al. 2007

WJG

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AIM:To investigate the therapeutic effect of tetrandrine on liver fibrosis induced by thioacetamide in rats in vivo and in vitro . METHODS:In vitro study: we investigated the effect of tetrandrine on the apoptosis of rat hepatic stellate cells transformed by simian virus 40 (T-HSC/Cl-6), which retains the features of activated cells. In vivo study: hepatic fibrosis was induced in rats by thioacetamide. Tetrandrine was given orally to rats at doses of 5, 10 or 20 mg/kg for 4 wk compared with intraperitoneal injection of interferon-г.

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The Effects of Tetrandrine on the Contractile Function and Microvascular Permeability in the Stunned Myocardium of Rats.

Cited by 4 publications

References 22 publications

Electropharmacological Actions of the Constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in Guinea Pig Heart

Electropharmacological Actions of the Constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in Guinea Pig Heart

Effect of Tetrandrine on Experimental Hepatic Fibrosis Induced by Bile Duct Ligation and Scission in Rats

Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model

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