The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

Farhangi, Mahdieh Abbasalizad; Mesgari‐Abbasi, Mehran; Nameni, Ghazaleh; Hajiluian, Ghazaleh; Shahabi, Parviz

doi:10.1186/s12868-017-0400-1

Cited by 42 publications

(24 citation statements)

References 54 publications

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“…The association between vitamin D and mental health was so far studied mainly for depression or depressive symptoms [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ] and some potential mechanisms explaining the influence of vitamin D were supposed [ 64 ]. Vitamin D has potential to cross the blood-brain barrier, to activate receptors in brain cells and to exert its direct impact in the central nervous system [ 65 ]. Moreover, there is some evidence for the link between vitamin D and Vitamin D Receptors (VDRs) and the regulation of human behavior, that is strongly suggested by the presence of VDRs in such brain areas as cortex, cerebellum and limbic system [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, studies in animal models indicated potential anti-inflammatory effects of vitamin D administration in hippocampus and hypothalamus and its modulating effects on brain-derived neurotropic factor (BDNF) [ 65 ] which may also play a role. Simultaneously, the role of vitamin D may be attributed to its neuroprotective role in the brain which is reflected in modulating neurotrophic signaling [ 69 ], and in regulating inflammation by inhibiting proinflammatory cytokines [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

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The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review

et al. 2021

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A potential role of vitamin D in some components of mental health is currently suggested, but the analyses are conducted mainly for adults, while for young individuals mental health is especially important, due to its lifelong effects. The aim of the study was to analyze the association between vitamin D intake or status and mental health in children within a systematic review of literature, including both intervention and observational studies. The literature search was conducted according to the PRISMA guidelines and it covered peer-reviewed studies included in databases of PubMed and Web of Science until October 2019. The studies presenting either vitamin D intake, or vitamin D status in human subjects were allowed (excluding subjects with intellectual disabilities, eating disorders and neurological disorders), while for mental health the various methods of assessment and wide scope of factors were included. The bias was assessed using the Newcastle–Ottawa Scale (NOS). The review was registered in the PROSPERO database (CRD42020155779). A number of 7613 studies after duplicate removing were extracted by two independent researchers, followed by screening and assessment for eligibility, conducted by two independent researchers in two steps (based on title and abstract). Afterwards, the full texts were obtained and after reviewing, a number of 24 studies were included. The synthetic description of the results was prepared, structured around exposure (vitamin D supplementation/status) and outcome (components of mental health). The included studies were conducted either in groups of healthy individuals, or individuals with mental health problems, and they assessed following issues: behavior problems, violence behaviors, anxiety, depressive symptoms/depression, aggressive disorder, psychotic features, bipolar disorder, obsessive compulsive disorder, suicidal incident, as well as general patterns, as follows: mental health, level of distress, quality of life, well-being, mood, sleep patterns. The vast majority of assessed studies, including the most prominent ones (based on the NOS score) supported potential positive influence of vitamin D on mental health in children. As a limitation of the analysis, it should be indicated that studies conducted so far presented various studied groups, outcomes and psychological measures, so more studies are necessary to facilitate comparisons and deepen the observations. Nevertheless, vitamin D intake within a properly balanced diet or as a supplementation, except for a safe sun exposure, should be indicated as an element supporting mental health in children, so it should be recommended to meet the required 25(OH)cholecalciferol blood level in order to prevent or alleviate mental health problems.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review

et al. 2021

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“…The rats were then categorized into four groups (six rats/each). The first one received no treatment (only CCT diet) and referred to as a control group or diabetic hyperlipidemic control (DHC) group), group 2 received 10-DHGD (extracted from ginger fresh rhizomes ( Zingiber officinale ) 10 mg/kg orally, 31,49 group 3 received vitamin D3 (the Medical Union of Pharmaceuticals (MUP, Egypt)) 500 IU/kg weekly administered by oral gavage, 50–52 group 4 received a combination therapy of 10-dehydrogingerdione and vitamin D3. Another group of normal rats (group 5) that received only chow diet was included and referred to normal group.…”

Section: Methodsmentioning

confidence: 99%

Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

Elseweidy

Aly

Hammad

et al. 2020

Exp Biol Med (Maywood)

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Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury. The present study aimed to illustrate the myocardial injury induced in a diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-DHGD intake either individually or in combination form. Male albino rats were selected for the study, received alloxan, hypercholesterolemic diet, and categorized into four groups. The first one (DHC), received hypercholesterolemic diet only and referred to as control. The remaining groups (2, 3, 4) received vitamin D3, 10-DHGD, and combination of both, respectively. Certain biomarkers that were selected for MI evaluation included blood glucose, lipogram pattern, Copeptin, C-reactive protein, myeloperoxidase, heart fatty acid-binding protein, and histopathological changes in myocardium and aorta. Vitamin D3 and 10-DHGD intake induced significant hypoglycemic, hypolipidemic effects, decreased inflammation, and MI biomarkers. Decreased myocardial vacuoles, foam cells, and intimal lesions were also observed compared to DHC. Their combination intake induced more marked reduction in all biomarkers and showed a histopathological pattern similar to normal features of myocardium and aorta. Our findings suggest the therapeutic roles of vitamin D3, 10-DHGD, and their combination against myocardial injury in diabetic hyperlipidemic rats. Impact statement Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury (MI). The present study aimed to illustrate the pattern of myocardial injury induced in diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-dehydrogingerdione (10-DHGD) intake either individually or in combination form.

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“…Previous studies showed an increased cytokine production, including interleukin-1β (IL-1β), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-α), in HT patients [ 25 , 26 ]. Vitamin D has been involved in modulating the secretion of cytokines, including TNF-α, IL-6, IL-1β, and MCP-1 [ 27 – 29 ]. Numerous studies support the notion that inflammation, characterized by elevated cytokines, play a pivotal role in the pathogenesis of cognitive impairment [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis

Zhu

Sun

et al. 2018

BMC Endocr Disord

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BackgroundCognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT.MethodsWe recruited 194 patients with HT and 200 healthy volunteers. Levels of serum 25-hydroxyvitamin D (25(OH)D) were measured using a competitive protein-binding assay. Cognitive funtion was assessed using Montreal Cognitive Assessment score (MoCA). Subjects with a MoCA scores < 26 are considered as having mild cognitive impairment (MCI). Multivariate analysis was performed using logistic regression models.ResultsFifty-five HT patients (28.4%) were diagnosed as having MCI. Patients with MCI had significantly lower 25(OH)D levels when compared with patients without MCI (33.9 ± 6.2 vs. 44.3 ± 9.6 nmol/L, P < 0.001). Significant differences in 25(OH)D quartiles of HT patients were observed between the patients with MCI and the patients without MCI (P < 0.001). In multivariate analyses, serum 25(OH)D levels (≤ 34.0 and ≥ 47.1 nmol/L) were significantly associated with cognitive impairment in patients with HT (OR 6.279, 95% CI 2.673–14.834, P < 0.001; OR 0.061, 95% CI 0.008–0.491, P = 0.009, respectively).ConclusionOur results demonstrate an important association between serum vitamin D levels and cognitive impairment in patients with HT.

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The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

Cited by 42 publications

References 54 publications

The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review

The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review

Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis

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