The efficacy in treatment of facial melasma with thulium 1927-nm fractional laser-assisted topical tranexamic acid delivery: a split-face, double-blind, randomized controlled pilot study

Laser‐assisted delivery of tranexamic acid for melasma: Pilot study using a novel 1927 nm fractional thulium fiber laser

“…However, at 180 days post‐treatment, some subjects began to experience recurrence of their melasma. This is consistent with the chronic and recurring nature of this cutaneous condition and the previous experiences with other treatment modalities, which have only offered short‐term improvement before recurrences were ultimately experienced 3,14,15 . Although clinical research has focused on finding an effective and lasting maintenance strategy following initial laser or tranexamic acid treatment, there has been limited success over the years.…”

“…The laser‐induced breakdown increases uptake of topically applied medications, which can increase local drug absorption and bioavailability while reducing the undesirable effects associated with systemic absorption. Several medications have been utilized, including tranexamic acid, bimatoprost, and poly‐L lactic acid 9‐14 …”

Lessons Learned from the First Decade of Laser-Assisted Drug Delivery

“…A split-face, double-blind, randomised controlled study of 46 melasma patients treated with a 1927-nm thulium laser on both sides of the face and with tranexamic acid on one side of the face was reported. Significant improvements were observed on both face sides, and there was no statistically significant difference in improvement between the sides [24]. Similar findings were reported for a randomized comparative split-face study of 30 melasma patients treated with a fractional ablative CO 2 laser alone or in combination with tranexamic acid [25].…”

Efficacy and safety of tranexamic acid in the treatment of adult melasma: An updated meta‐analysis of randomized controlled trials

“…Eight studies [14][15][16][17][18][19][20][21] evaluated the efficacy and safety of oral TXA, four studies [22][23][24][25] evaluated the efficacy and safety of intradermal TXA, and twelve studies evaluated the efficacy and safety of topical TXA. 5,[26][27][28][29][30][31][32][33][34][35][36] In the study by Tawfic SO, 30 topical and intradermal TXA administration routes were adopted in the treatment arm; thus, the study was analysed separately.…”