The efficacy of black cumin seed (<i>Nigella sativa</i>) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk

Rachman, P N R; Akrom,; Darmawan, Endang

doi:10.1088/1757-899x/259/1/012018

Cited by 18 publications

(21 citation statements)

References 19 publications

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“…Furthermore, an experimental randomized controlled trial of 99 diabetes patients received the placebo and two treatment groups received oral black seed oil. Administration of 1.5 and 3 mL/day of black seed oil for 20 days showed meaningful reduction of glycated hemoglobin A1c and random blood sugar levels [48]. The effect of N. sativa seed on the glycemic control of patients with type-2 diabetes (DM-2) was also used as an adjunctive treatment added to their oral hypoglycemic agents.…”

Section: Pharmacological Activities Of Nigella Sativamentioning

confidence: 99%

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Yimer

Tuem

Karim

et al. 2019

Evidence-Based Complementary and Alternative Medicine

325

228

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The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections. In spite of limited studies conducted so far, the promising efficacy of N. sativa against HIV/AIDS can be explored as an alternative option for the treatment of this pandemic disease after substantiating its full therapeutic efficacy. Moreover, the strong antioxidant property of this valued seed has recently gained increasing attention with regard to its potential role as dietary supplement with minimal side effects. Besides, when combined with different conventional chemotherapeutic agents, it synergizes their effects resulting in reducing the dosage of concomitantly used drugs with optimized efficacy and least and/or no toxicity. A number of pharmaceutical and biological properties have been ascribed to seeds of N. sativa. The present review focuses on the profile of high-value components along with traditional medicinal and biological principles of N. sativa seed and its oil so as to explore functional food and nutraceutical potential of this valued herb.

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Section: Pharmacological Activities Of Nigella Sativamentioning

confidence: 99%

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Yimer

Tuem

Karim

et al. 2019

Evidence-Based Complementary and Alternative Medicine

325

228

View full text Add to dashboard Cite

show abstract

“…This analytic observational study with a cohort design aims to determine the effectiveness of BCSO administration to TNF-α levels, and creatinine in patients at risk of metabolic syndrome at Jetis I Public Health Center (PHC), Bantul, Yogyakarta. The study was conducted in July 2017-July 2018 [7].…”

Section: Materials and Methods A Designmentioning

confidence: 99%

“…Blood samples came from 61 outpatient SM at-risk patients in the Bantul Jetis I Public Health Center. Blood samples came from 61 SM at-risk patients from a previous study conducted by Akrom et al, at the Jetis 1 PHC, Bantul [7]. Blood samples have been taken by trained personnel by protocols that have been approved by the Ahmad Dahlan University ethics committee.…”

Section: Materials and Methods A Designmentioning

confidence: 99%

“…Increased reactive oxygen superfamily (ROS) in metabolic syndrome can cause damage to blood vessel endothelium and cause inflammatory reactions [2] [7]. Tumor necrosis factor-alpha (TNF-α) is a cytokine that is involved in the systemic inflammatory response in adipose tissue, endothelial dysfunction, and is associated with insulin resistance, obesity, and diabetes [8].…”

Section: Introductionmentioning

confidence: 99%

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Tumor Necrosis Factor Alpha (Tnf-α) and Creatinine Levels in Patients at Risk of Metabolic Syndrome with Standard Therapy Combined with Black Cumin Seed Oil

Rahmawaty¹,

Akrom²,

Darmawan³

et al. 2021

Proceedings of the 1st Paris Van Java International Seminar on Health, Economics, Social Science and Humanities (PVJ-ISHESSH 20

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Oxidative stress in metabolic syndrome (MS) results in vascular endothelial damage, generates inflammatory reactions, and increases the risk of impaired kidney function. Black cumin seed oil (BCSO) is thought to be able to improve the immune response and protect damage to the kidneys. The purpose of this study was to determine the effect of BCSO on TNF-α and creatinine levels in patients at risk of metabolic syndrome with standard therapy at the Jetis I Public health center (PHC). This study uses stored biological material (BM) of patients at risk of outpatient metabolic syndrome in Jetis I PHC, Bantul, for the period July 2017 to July 2018. Researchers used 61 blood specimens of patients at risk of MS, 30 of patients at risk of MS with a combination of standard therapy +BCSO, and 31 patients at risk of MS with standard + placebo combination therapy. The administration of BCSO has been done for 20 days. On the 21st day, a blood sample was taken. Blood creatinine levels were measured by the Jaffe method. TNF-α levels were determined by the enzyme-linked immunosorbent assay (ELISA) method in the Clinical Pathology Laboratory of the Faculty of Medicine UGM. Differences in TNF-α levels and creatinine levels between groups were analyzed using independent samples ttest (95% confidence level). TNF-α levels did not differ between the two groups (p> 0.05). The TNF-α levels of the BCSO group were 101.43 ± 22.89 nmol/ml, and the placebo group 106.73 ± 30.03 nmol/ml. There was no statistically significant difference in creatinine levels between the two groups (p <0.05), but it was clinically significant. The creatinine content of the BCSO group was 1.16 ± 0.19 mg/ml, and the placebo group was 1.35 ± 0.32 mg/ml with a p value> 0.05, but it was clinically significant. Based on the results of this study, it can be concluded that the administration of BCSO additional therapy has no effect on TNF-α levels but has an impact on creatinine levels in patients at risk of metabolic syndrome in Jetis I primary care center, Bantul Yogyakarta.

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“…In several clinical trials ( Table 3 ), including those on hyperlipidemic patients with a smoking habit [ 123 ], menopausal women with metabolic diseases [ 124 ], outpatients of metabolic syndrome [ 125 ], and patients bearing Hashimoto’s thyroiditis [ 126 ], administration of black cumin seeds in different formulations significantly improved lipid profile and blood sugar. Along with the preclinical findings, observations from these clinical studies suggest that black cumin could be a promising candidate for anti-obesity and anti-hyperlipidemic agents.…”

Section: Benefits Of Black Cumin On Human Health and Disease Conditionsmentioning

confidence: 99%

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

et al. 2021

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Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress and inflammation, and to promote immunity, cell survival, and energy metabolism, which underlie diverse health benefits, including protection against metabolic, cardiovascular, digestive, hepatic, renal, respiratory, reproductive, and neurological disorders, cancer, and so on. Furthermore, black cumin acts as an antidote, mitigating various toxicities and drug-induced side effects. Despite significant advances in pharmacological benefits, this miracle herb and its active components are still far from their clinical application. This review begins with highlighting the research trends in black cumin and revisiting phytochemical profiles. Subsequently, pharmacological attributes and health benefits of black cumin and TQ are critically reviewed. We overview molecular pharmacology to gain insight into the underlying mechanism of health benefits. Issues related to pharmacokinetic herb–drug interactions, drug delivery, and safety are also addressed. Identifying knowledge gaps, our current effort will direct future research to advance potential applications of black cumin and TQ in health and diseases.

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The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk

Cited by 18 publications

References 19 publications

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Tumor Necrosis Factor Alpha (Tnf-α) and Creatinine Levels in Patients at Risk of Metabolic Syndrome with Standard Therapy Combined with Black Cumin Seed Oil

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

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