The Efficacy of Integrated Rehabilitation for Post-Stroke Anxiety: Study Protocol for a Prospective, Multicenter, Randomized Controlled Trial

Zhou, Jie; Fan, Lijuan; Hu, Hantong; Shen, Ke; Wu, Lei; Lin, Xiaoqi; Gao, Hong

doi:10.2147/ijgm.s381434

Cited by 3 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chinese herbal medicine (CHM), one of the important therapeutic methods in traditional Chinese medicine (TCM), has a complete theoretical system and has long been used in combination with Western medicine (WM) to treat various diseases ( Wang et al, 2013 ; Zhou et al, 2022 ). CHM is mainly derived from traditional botanicals, animals and minerals, of which botanicals are the most common.…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background: Type 2 diabetes mellitus (T2DM) is a clinical metabolic syndrome characterized by persistent hyperglycemia. Patients with T2DM are more likely to have carotid atherosclerosis (CAS), which can lead to dizziness, amaurosis or even stroke. Chinese herbal medicine (CHM) has shown possible efficacy and safety in treating T2DM patients with CAS. However, the existing evidence was not robust enough and the results were out of date.Objective: This meta-analysis aimed to summarize the current evidence and systematically evaluate the effects of CHM on carotid plaque, glucose and lipid metabolism and vascular endothelial parameters in T2DM patients with CAS, providing a reference for subsequent research and clinical practice.Methods: This study was registered in PROSPERO as CRD42022346274. Both Chinese and English databases were searched from their inceptions to 16 July 2022. All retrieved studies were screened according to inclusion and exclusion criteria. Randomized controlled trials (RCTs) using oral CHM to treat T2DM patients with CAS were included. The literature quality was assessed using the risk of bias assessment tool in the Cochrane Handbook. Data extraction was conducted on the selected studies. Review Manager 5.4 and Stata 16.0 were used for meta-analysis. Sources of heterogeneity were explored by meta-regression or subgroup analysis. Funnel plot and Egger’s test were used to assess publication bias and the evidence quality was assessed by Grading of Recommendations Assessment, Development and Evaluation (GRADE).Results: 27 eligible studies, involving 2638 patients, were included in this study. Compared with western medicine (WM) alone, the addition of CHM was significantly better in improving carotid intima-media thickness (CIMT) [mean difference (MD) = -0.11mm, 95% confidence interval (CI): −0.15 to −0.07, p < 0.01], carotid plaque Crouse score [MD = −1.21, 95%CI: −1.35 to −1.07, p < 0.01], total cholesterol (TC) [MD = −0.34 mmol/L, 95%CI: −0.54 to −0.14, p < 0.01], triglyceride (TG) [MD = −0.26 mmol/L, 95%CI: −0.37 to −0.15, p < 0.01], low-density lipoprotein cholesterol (LDL-C) [MD = −0.36 mmol/L, 95%CI: −0.47 to −0.25, p < 0.01], high-density lipoprotein cholesterol (HDL-C) [MD = 0.22 mmol/L, 95%CI: 0.13 to 0.30, p < 0.01], glycated hemoglobin (HbA1c) [MD = −0.36%, 95%CI: −0.51 to −0.21, p < 0.01], fasting blood glucose (FBG) [MD = −0.33 mmol/L, 95%CI: −0.50 to −0.16, p < 0.01], 2-h postprandial glucose (2hPG) [MD = −0.52 mmol/L, 95%CI: −0.95 to −0.09, p < 0.01], homeostasis model assessment of insulin resistance (HOMA-IR) [standardized mean difference (SMD) = −0.88, 95%CI: −1.36 to −0.41, p < 0.01] and homeostasis model assessment of beta-cell function (HOMA-β) [MD = 0.80, 95%CI: 0.51 to 1.09, p < 0.01]. Due to the small number of included studies, it is unclear whether CHM has an improving effect on nitric oxide (NO), endothelin-1 (ET-1), peak systolic velocity (PSV) and resistance index (RI). No serious adverse events were observed.Conclusion: Based on this meta-analysis, we found that in the treatment of T2DM patients with CAS, combined with CHM may have more advantages than WM alone, which can further reduce CIMT and carotid plaque Crouse score, regulate glucose and lipid metabolism, improve insulin resistance and enhance islet β-cell function. Meanwhile, CHM is relatively safe. However, limited by the quality and heterogeneity of included studies, the efficacy and safety of CHM remain uncertain. More high-quality studies are still needed to provide more reliable evidence for the clinical application of CHM.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022346274

show abstract

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

Hope and health promoting intention among stroke patients in China: the mediating role of self-efficacy

Chen,

Huang,

Cao

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction: Stroke is one of the major diseases that threaten life and health globally, and reducing the risk of recurrence after stroke and promoting the recovery of physical and mental functions are significant challenges in solving the health problems of stroke patients. Compared to surgical and pharmacologic treatments, relatively few studies have focused on improving health promoting intention in stroke patients to enhance disease prognosis. This study aimed to explore the relationship between health promoting intention, hope, and self-efficacy. Methods From June 2023 to November 2023, a questionnaire survey was conducted among 521 stroke patients in the affiliated hospitals of Hunan University of Chinese Medicine using cluster sampling. The survey instruments included a general demographics questionnaire, Health-Promoting Lifestyle Scale II, General Self Efficacy Scale, and Herth Hope Index. Multiple regression analysis was used to explore the influencing factors of health promoting intention, and structural equation modeling was constructed to test the mediating role of self-efficacy between hope and health promoting intention. Results A total of 499 valid questionnaires were included. There was a significant positive correlation between health promoting intention, hope, and self-efficacy (p < 0.01). Hope (β = 2.812, p < 0.01), self-efficacy (β = 6.712, p < 0.001), and disease knowledge (β = 0.167, p < 0.001) significantly and positively influenced health promoting intention. Self-efficacy partially mediated the relationship between hope and health promoting intention [β = 0.258, 95%CI (0.126, 0.401)], with the indirect effect accounting for 41.55%. Conclusion This study confirmed the significant positive effect of hope on health promoting intention, with self-efficacy mediating between the two. Future research should explore other influences on health promoting intention to develop a comprehensive health promotion behavioral intervention program for stroke patients.

show abstract

A novel digital approach for post-stroke cognitive deficits: a pilot study

Oliveri

Bagnato

Rizzo

et al. 2023

Restorative Neurology and Neuroscience

View full text Add to dashboard Cite

Background: Cognitive dysfunctions after a brain stroke have a huge impact on patients’ disability and activities of daily living. Prism adaptation (PA) is currently used in patients with right brain damage to improve lateralized spatial attentional deficits. Recent findings suggest that PA could also be useful for rehabilitation of other cognitive functions. Objective: In the present study, we tested for the efficacy on cognitive rehabilitation of a novel device in which the procedure of prism adaptation is digitized and followed by cognitive training of attention and executive functions using serious games. Methods: Thirty stroke patients were randomly assigned to two groups: an experimental group of 15 patients, which performed the experimental rehabilitation training using the novel device in 10 consecutive daily sessions; a control group of 15 patients, which performed the routine cognitive training in 10 consecutive daily sessions. Both groups were tested before and after the rehabilitation program on neuropsychological tests (digit and spatial span forward and backward, attentional matrices, Stroop task) and on functional scales (Barthel index and Beck Anxiety Index). Results: The main results showed that only patients who received the experimental rehabilitation training improved their scores on tests of digit span forward, spatial span backward, attentional matrices and Stroop. Moreover, patients of the experimental but not of the control group showed a significant correlation between improvement on some tasks (mainly spatial span backward) and improvement on activities of daily living as well as with reduction of anxiety levels. Conclusions: These results suggest that combining digital PA with cognitive training using serious games may be added in clinical settings for cognitive rehabilitation of stroke patients, with beneficial effects extending in promoting independency in activities of daily living and reduction of psychiatric symptoms.

show abstract

The Efficacy of Integrated Rehabilitation for Post-Stroke Anxiety: Study Protocol for a Prospective, Multicenter, Randomized Controlled Trial

Cited by 3 publications

References 52 publications

The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials

The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials

Hope and health promoting intention among stroke patients in China: the mediating role of self-efficacy

A novel digital approach for post-stroke cognitive deficits: a pilot study

Contact Info

Product

Resources

About