The Electrochemical Behavior of Nitrazepam at a Screen‐Printed Carbon Electrode and Its Determination in Beverages by Adsorptive Stripping Voltammetry

McGuire, Natasha D.; Honeychurch, Kevin C.; Hart, John P.

doi:10.1002/elan.200904667

Cited by 17 publications

(10 citation statements)

References 28 publications

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“…pharmaceuticals. Some pharmaceutical applications using this type of electrodes are: the quantitative analysis of paracetamol on an untreated screen-printed carbon electrode (SPCE) using amperometric detection coupled to a FIA system [13], the determination of lamotrigine by differential pulse adsorptive stripping voltammetry (DPAdSTV) using SPCE [14], and the electrochemical determination of nitrazepam at a SPCE using AdSV [15].…”

Section: Introductionmentioning

confidence: 99%

Determination of Nifuroxazide by Flow Injection Linear Adsorptive Stripping Voltammetry on a Screen‐Printed Carbon Nanofiber Modified Electrode

Mozo¹,

Carbajo²,

Sturm³

et al. 2012

Electroanalysis

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Artículo de publicación ISIA new, sensitive, reproducible and easy-to-use flow-injection method for determining nifuroxazide based on adsorptive stripping linear sweep voltammetry over screen-printed carbon electrodes is presented. The presented method is the first report of Nifuroxazide determination using a screen printed electrode and FIA and it is useful for pharmaceutical quality control, specifically, it could be adopted as an effective portable tool for on the shelf quality control at pharmacies.Limits of quantification (LOQ) and detection (LOD) as low as 42 and 10 ng/mL, respectively, were found. An average recovery of 100.7%, and a standard deviation of 2.5 % indicates acceptable accuracy and precision validating the proposed method.FONDECYT (Grant No. 1090120), the AIQB Chair at the University of Huelva and PAIDi from Junta de Andalucí

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Section: Introductionmentioning

confidence: 99%

Determination of Nifuroxazide by Flow Injection Linear Adsorptive Stripping Voltammetry on a Screen‐Printed Carbon Nanofiber Modified Electrode

Mozo¹,

Carbajo²,

Sturm³

et al. 2012

Electroanalysis

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“…Many researchers have expressed the need for miniaturisation of electrochemical setups and for the continuation of electroanalytical studies. 10 The ongoing pursuit within the electroanalytical eld using screen-printed electrodes is extremely diverse with many research groups applying these in a range of analytical pursuits allowing "in-eld" analysis where miniaturisation and portability can be realised. Other researchers such as Honeychurch et al 9 have focused upon analytes such as diazepam 9 and nitrazepam.…”

Section: Introductionmentioning

confidence: 99%

Exploring the electrical wiring of screen-printed configurations utilised in electroanalysis

et al. 2015

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In this technical note the often overlooked issue of electrically connecting screen-printed electrode sensors is considered. The electrical connection of screen-printed electrodes to the potentiostat/ electronics can be a main issue when a true electrochemical response is trying to be obtained and if one does not have a stable electrical connection, the results that are obtained may lack reproducibility and therefore maybe discredited as "another failed electrochemical probe/analyte". This paper considers the case of electrically connecting screen-printed with crocodile clips and compares that to the use of edge-connectors demonstrating the precise connection of an electrode setup when utilising crocodile clips can result in extremely reproducible electrochemical outputs when applied correctly.

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“…In previous studies we have shown that it was possible to use µL sample volumes for the determination of other benzodiazepines [28] and nitroaromatics compounds [35]. As it was our goal to apply these devices in the area of bioanalysis and forensic investigations, where the collection of large sample volumes can be problematic, we investigated the possibility of using a similar approach.…”

Section: Effect Of Sample Volumementioning

confidence: 99%

“…Recently, Martins et al [27] Previously, we have determined a variety of benzodiazepines using both screen-printed carbon electrodes (SPCEs) [28,29]. Consequently, we considered that it should be feasible to develop an electrochemical for the determination of clonazepam, using a SPCE.…”

Section: Introductionmentioning

confidence: 99%

Development of a voltammetric assay, using screen-printed electrodes, for clonazepam and its application to beverage and serum samples

Honeychurch

Brooks

Hart

2016

Talanta

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Development of a voltammetric assay, using screen-printed electrodes, for clonazepam and its application to beverage and serum samples. Talanta, 147. pp. 510-515. ISSN 0039-9140 Available from: http://eprints.uwe.ac.uk/27297We recommend you cite the published version. The publisher's URL is: http://dx.doi.org/10.1016/j.talanta.2015.10.032Refereed: Yes (no note) Disclaimer UWE has obtained warranties from all depositors as to their title in the material deposited and as to their right to deposit such material. UWE makes no representation or warranties of commercial utility, title, or fitness for a particular purpose or any other warranty, express or implied in respect of any material deposited. UWE makes no representation that the use of the materials will not infringe any patent, copyright, trademark or other property or proprietary rights. UWE accepts no liability for any infringement of intellectual property rights in any material deposited but will remove such material from public view pending investigation in the event of an allegation of any such infringement. AbstractThis paper describes the development of an electrochemical assay based on screen-printed carbon sensors for the determination of clonazepam in serum and in wine. The cyclic voltammetric behaviour of the drug was investigated and the effects of pH and scan rate on the peak current and peak potential determined. Two reduction peaks were recorded on the initial negative going scan, which were considered to result from the 2e -, 2H + reduction of the 4,5-azomethine and from the 4e -, 4H + reduction of the 7-NO 2 to a hydroxylamine. On the return positive going scan an oxidation peak was seen, which was considered to result from the 2e -, 2H + oxidation (O1) of the hydroxylamine to the corresponding nitroso species.At pH 11 the solution of clonazepam was found to turn from clear to yellow in colour and the voltammetric signal of the O1 oxidation process was found to be adsorptive in nature, this was exploited in the development of an adsorptive stripping voltammetric assay.Experimental conditions were then optimised for the differential pulse adsorptive voltammetric measurement of clonazepam in wine and serum samples. It was shown that these analyses could be performed on only 100 µL of sample which was deposited on the sensor surface. Mean recoveries of 79.53 % (%CV = 9.88 %) and 88.22 % (%CV = 14.1 %) 2 were calculated for wine fortified with 3.16 µg/mL and serum fortified with 12.6 µg/mL respectively.

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The Electrochemical Behavior of Nitrazepam at a Screen‐Printed Carbon Electrode and Its Determination in Beverages by Adsorptive Stripping Voltammetry

Cited by 17 publications

References 28 publications

Determination of Nifuroxazide by Flow Injection Linear Adsorptive Stripping Voltammetry on a Screen‐Printed Carbon Nanofiber Modified Electrode

Determination of Nifuroxazide by Flow Injection Linear Adsorptive Stripping Voltammetry on a Screen‐Printed Carbon Nanofiber Modified Electrode

Exploring the electrical wiring of screen-printed configurations utilised in electroanalysis

Development of a voltammetric assay, using screen-printed electrodes, for clonazepam and its application to beverage and serum samples

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