The electrokinetic properties of phospholipid stabilized fat emulsions. V. The effect of amino acids on emulsion stability

Washington, C.; Connolly, M.A.; Manning, Ray; Skerratt, M.C.L.

doi:10.1016/0378-5173(91)90301-4

Cited by 24 publications

(7 citation statements)

References 7 publications

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“…The observed effect of emulsion stabilisation by the acidic drug fluf correlates very well with the observation that amino acids, at pH values where they are negatively charged, lead to a stabilisation of phospholipid-stabilised emulsions ( Washington et al, 1991 ). The authors of the respective study assumed an effect caused by Van der Waals forces, since also their investigations did not reveal an exclusive correlation to electrostatic effects.…”

Section: Resultssupporting

confidence: 76%

“…Freeze-thaw cycles can also be used but are considered less relevant for intravenous emulsions and have been discussed critically with regard to the effect of agents located in the aqueous phase ( Han and Washington, 2005 ). There are also alternative test methods such as, for example, the observation of droplet flocculation after electrolyte addition as indication for instability ( Washington et al, 1991 ) or autoclaving to investigate emulsion stability by heat treatment ( Sznitowska et al, 2001 ). For the investigations in the present study, a shaking test was developed that facilitated a fast stability check on highly stable emulsions.…”

Section: Introductionmentioning

confidence: 99%

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Influence of drug loading on the physical stability of phospholipid-stabilised colloidal lipid emulsions

Francke

Bunjes

2020

International Journal of Pharmaceutics: X

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When poorly water-soluble drugs are formulated in colloidal lipid emulsions, adequate stability of the emulsion must be ensured. The aim of this work was to investigate different aspects related to drug loading in order to gain a better understanding on how drugs affect the stability of phospholipid-stabilised emulsions. To obtain information on emulsion stability, a rapid and reproduceable shaking test was developed. A passive loading approach was applied for drug loading of the commercially available nanoemulsion Lipofundin® MCT/LCT 10% with seven drugs of different charge and localisation tendency within the emulsion system. Localisation of drug molecules in the droplet interface did not generally lead to destabilisation of the emulsion, whereas the charge of the drug was of decisive importance. Aspects such as the drug concentration, its influence on the pH and the impact of zeta potential changes had an influence on emulsion stability as well. Certain destabilising effects of drugs could be counteracted by modification of the pH. Lipofundin® MCT/LCT 10%, passively loaded with propofol, was compared with two commercially available propofol preparations. No negative effect of the passive loading procedure could be detected.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Influence of drug loading on the physical stability of phospholipid-stabilised colloidal lipid emulsions

Francke

Bunjes

2020

International Journal of Pharmaceutics: X

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“…These findings are consistent with the stabilising effect of amino acids reported by Washington et al (1991) and Barat et al (1987). Washington stating that the emulsion is partially stabilised by complexation of calcium with amino acids.…”

Section: Discussionsupporting

confidence: 82%

An interfacial equilibria model for the electrokinetic properties of a fat emulsion. Part III: A predictive computer model

Gaskin

Hall

Duffield

et al. 1997

Chemical Speciation & Bioavailability

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The semi-empirical thermodynamic model for the binding of metal ions to an emulsion (intralipid 20%) reported previously (Hallet a/., 1991; Gaskin eta/., 1993) is incorporated into a thermodynamic computer model. This permits the zeta potential and emulsion stability together with precipitate formation to be estimated for any intravenous nutrition regimen. A regimen frequently used in the intravenous nutrition of patients is considered in this modeling study. The effect of solution pH and calcium on the zeta potential of the emulsion is predicted. Calcium and magnesium are the only metal cations which are predicted to be of importance when considering stability of this emulsion.

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“…The stabilizing influence of AAs on TNA stability have been reviewed. 29 Among the fluctuations in PFAT 5 levels observed in admixtures 1-4 over time, 2 exhibited a net fall from time 0-30 hours (1 and 3), while the other 2 slightly rose over the same time. This behavior is more consistent with changes observed during the early stages of emulsion instability with creaming and modest levels of droplet aggregation as the emulsion is initially stressed.…”

Section: Discussionmentioning

confidence: 94%

Stability of MCT/LCT‐Based Total Nutrient Admixtures for Neonatal Use Over 30 Hours at Room Temperature

Driscoll

Silvestri

Bistrian

2010

J Parenter Enteral Nutr

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The electrokinetic properties of phospholipid stabilized fat emulsions. V. The effect of amino acids on emulsion stability

Cited by 24 publications

References 7 publications

Influence of drug loading on the physical stability of phospholipid-stabilised colloidal lipid emulsions

Influence of drug loading on the physical stability of phospholipid-stabilised colloidal lipid emulsions

An interfacial equilibria model for the electrokinetic properties of a fat emulsion. Part III: A predictive computer model

Stability of MCT/LCT‐Based Total Nutrient Admixtures for Neonatal Use Over 30 Hours at Room Temperature

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